Mo1087 Esophagoprotective Activity of Angiotensin-(1-7) in Rat Model of Acute Reflux Esophagitis. Role of Sensory Neuropetides and Proinflammatory Cytokines

Pawlik, Michael W.; Kwiecień, Sławomir; Pajdo, Robert; Ptak‐Belowska, Agata; Drozdowicz, Danuta; Pawlik, Wiesław W.; Konturek, Stanisław J.; Brzozowski, Tomasz

doi:10.1016/s0016-5085(12)62267-7

Cited by 13 publications

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“…Since the discovery of Ang-(1-7) in 1976, the presence of this hectapeptide has been detected in brain, blood vessels, heart, kidney, liver, and stomach. Ang-(1-7) acting via its own G protein-coupled receptor (GPCR) called Mas Receptor exhibit the vasodilatory, antihyper tensive and cardio-protective (1).…”

Section: Discussionmentioning

confidence: 99%

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Possible contribution of nitric oxide and prostaglandin in the protective effect of angiotensin (1-7) against stress induced gastric ulceration in adult male albino rats

A.¹,

Aziz²,

Muralinath.E³

et al. 2017

BLL

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To assess the gastro-protective potential of the angiotensin (Ang-) (1-7) on the gastric secretion and ulceration induced by cold restraint stress (CRS) in adult male rats and the possible contribution of nitric oxide and prostaglandin E 2 . Rats were pylorically ligated and divided randomly into the following groups (8 rats each): control, cold-restraint stressed (CRS), stressed Ang-(1-7) treated, stressed L-NNA-Ang-(1-7) treated, stressed Indo-Ang-(1-7) treated groups. Our results revealed that Ang-(1-7) pre-treatment proved to be protective against development of ulcerative lesions in CRS model as evidenced by histological examination and the reduction of the ulcer index and this could be mediated through reduction of free and total acidity and pepsin concentration of gastric secretion with signifi cantly decreased lipid peroxidation and increased the gastric protective nitric oxide and prostaglandin E 2 levels. Furthermore, Ang-(1-7) pre-treatment has anti-apoptotic effect, evident by its down-regulation of the CRS induced over-expression of the gastric caspase 3. In addition, the gastro-protective effects of Ang-(1-7) were signifi cantly attenuated by co-administration with L-NNA or indomethacin. In conclusion, Ang-(1-7) can be considered a potential therapeutic agent to protect against the major clinical challenge of gastric injury resulting from stress. Nitric oxide and prostaglandin E 2 seem to contribute to the Ang-(1-7)'s gastro-protective effect (Tab. 2, Fig. 5, Ref. 35). Text in PDF www.elis.sk.

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Section: Discussionmentioning

confidence: 99%

“…More recently, it has been recognized that local RAS is present in most organs, including the gastrointestinal tract. The components of local RAS are present in the stomach, small intestine, colon, pancreatic islets, and liver (1).…”

Section: Introductionmentioning

confidence: 99%

Possible contribution of nitric oxide and prostaglandin in the protective effect of angiotensin (1-7) against stress induced gastric ulceration in adult male albino rats

A.¹,

Aziz²,

Muralinath.E³

et al. 2017

BLL

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“…The vasoconstrictive action of Ang II in hypertension is limited by vasoactive Ang-(1-7) and bradykinin (Oliveira et al, 1999;Greco et al, 2006;Sampaio et al, 2007). Ang-(1-7) exhibited esophagoprotection against reflux esophagitis (Pawlik et al, 2012), but whether Ang-(1-7) protects the gastric mucosa against stress lesions due to an increase of NO and the activity of prostaglandin (PG)/COX-1 and PG/COX-2 pathways and/or sensory nerves has not been extensively studied so far.…”

Section: Abbreviationsmentioning

confidence: 99%

RETRACTION: Role of Angiotensin-(1–7) in Gastroprotection against Stress-Induced Ulcerogenesis. The Involvement of Mas Receptor, Nitric Oxide, Prostaglandins, and Sensory Neuropeptides

Magierowski

Jasnos

Pawlik

et al. 2013

J Pharmacol Exp Ther

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Angiotensin-(1-7) [Ang-(1-7)] is a major vasoactive metabolite of angiotensin I (Ang I), both being important components of the renin-angiotensin system (RAS). Ang-(1-7) acting via Mas receptor was documented in kidneys, heart, brain, and gastrointestinal (GI)-tract. We studied the gastroprotective activity of exogenous Ang-(1-7) in rats exposed to water immersion and restraint stress (WRS) without or with A-779, the agonist of Ang-(1-7) receptor, as well as the inhibition of nitricoxide (NO) synthase, the suppression of cyclo-oxygenase (COX)-1 (indomethacin, SC-560 [5-(4-chloro-phenyl)-1-(4-methoxyphenyl)-3-trifluoromethyl-pyrazole]), the activity COX-2 (rofecoxib), and denervation with capsaicin. The mRNA expression of constitutively expressed nitric-oxide synthase (cNOS), inducible nitric-oxide synthase (iNOS), interleukin (IL)-1b, and tumor necrosis factor (TNF)-a was analyzed by reverse transcription polymerase chain reaction. The WRS lesions were dose-dependently reduced by pretreatment with Ang-(1-7), which also caused an increase in gastric blood flow (GBF) and luminal content of NO. COX-1 and COX-2 inhibitors or L-NNA (N5-[imino(nitroamino)methyl]-L-ornithine) reversed the reduction in lesion number and the rise in GBF evoked by Ang-(1-7). Ang II augmented the WRS lesions, decreased GBF and increased the plasma IL-1b and TNF-a levels. Capsaicin denervation attenuated the reduction of Ang-(1-7)-induced gastric lesions and the rise in GBF; these effects were restored by supplementation with calcitonin gene-related peptide (CGRP). The cNOS mRNA was upregulated while iNOS, IL-1b and TNF-a mRNAs were downregulated in Ang-(1-7)-pretreated rats. We conclude that Ang-(1-7), in contrast to Ang II, which worsened WRS ulcerogenesis, affords potent gastroprotection against WRS ulcerogenesis via an increase in GBF mediated by NO, endogenous prostaglandins, sensory neuropeptides, and anti-inflammatory action involving the inhibition of proinflammatory markers iNOS, IL-1b, and TNF-a.

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“…In a model of acute reflux oesophagitis, Ang(1–7) exerts a protective effect on the oesophagus through the involvement of NO, sensory nerve hypoxia‐inducible factor‐1α and pro‐inflammatory cytokines IL‐1β and TNF‐α (Pawlik et al, ). In an acetic acid‐induced gastric ulcer model, Ang(1–7) accelerates the healing of pre‐existing gastric ulcers by increasing the macro‐ and microcirculation, which increases gastric tissue oxygenation.…”

Section: Experimental Model Studiesmentioning

confidence: 99%

Significance of angiotensin 1–7 coupling with MAS1 receptor and other GPCRs to the renin‐angiotensin system: IUPHAR Review 22

Karnik

Singh

Tirupula

et al. 2017

British J Pharmacology

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This paper, written by members of the International Union of Basic and Clinical Pharmacology Committee on Receptor Nomenclature and Drug Classification (NC-IUPHAR) subcommittees for the angiotensin receptors, confirms the existing nomenclature for these receptors and reviews our current understanding of their structure, pharmacology and functions, and their likely physiological roles in health and disease. More information on these receptor families can be found in the Concise Guide to PHARMACOLOGY Angiotensins are a group of hormonal peptides and include angiotensin II and angiotensin 1-7 produced by the renin angiotensin system. The biology, pharmacology and biochemistry of the receptors for angiotensins were extensively reviewed recently. In the review, the receptor nomenclature committee was not emphatic on designating MAS1 as the angiotensin 1-7 receptor on the basis of lack of classical G protein signalling and desensitization in response to angiotensin 1-7, as well as a lack of consensus on confirmatory ligand pharmacological analyses. A review of recent publications (2013-2016) on the rapidly progressing research on angiotensin 1-7 revealed that MAS1 and two additional receptors can function as 'angiotensin 1-7 receptors', and this deserves further consideration. In this review we have summarized the information on angiotensin 1-7 receptors and their crosstalk with classical angiotensin II receptors in the context of the functions of the renin angiotensin system. It was concluded that the receptors for angiotensin II and angiotensin 1-7 make up a sophisticated cross-regulated signalling network that modulates the endogenous protective and pathogenic facets of the renin angiotensin system.

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Mo1087 Esophagoprotective Activity of Angiotensin-(1-7) in Rat Model of Acute Reflux Esophagitis. Role of Sensory Neuropetides and Proinflammatory Cytokines

Cited by 13 publications

References 0 publications

Possible contribution of nitric oxide and prostaglandin in the protective effect of angiotensin (1-7) against stress induced gastric ulceration in adult male albino rats

Possible contribution of nitric oxide and prostaglandin in the protective effect of angiotensin (1-7) against stress induced gastric ulceration in adult male albino rats

RETRACTION: Role of Angiotensin-(1–7) in Gastroprotection against Stress-Induced Ulcerogenesis. The Involvement of Mas Receptor, Nitric Oxide, Prostaglandins, and Sensory Neuropeptides

Significance of angiotensin 1–7 coupling with MAS1 receptor and other GPCRs to the renin‐angiotensin system: IUPHAR Review 22

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