Mo1103 EFFECT OF WEICHANG'AN PILL ON TH17/TREG IMMUNE BALANCE IN MICE WITH ULCERATIVE COLITIS

Zhang, Tao; Wei, Wei; Xiaolan, Su; Mao, Xinyong; Yang, Yang; Song, Gengqing

doi:10.1016/s0016-5085(20)32644-5

Cited by 3 publications

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“…TNBS rat [96] Qingchang Huashi Recipe Downregulate IDO1 expression, RORct, and related proinflammatory factors and upregulate Foxp3 and related antiinflammatory factors TNBS mice [97] Huangqin Decoction Restoration of balance through regulatory effects on 17 and Treg cytokines and transcription factors TNBS rat [98] Liancao Xieli Capsule Decrease the expression levels of p-STAT3 and RORct proteins and increase the expression levels of p-STAT5 and Foxp3 proteins DSS mice [99] Wei Chang An Pill Increasing the percentage of Treg cells and downregulating the percentage of 17 cells DSS mice [100] Kaijieling Inhibit the STAT3 pathway TNBS rat [101][102][103] Xiaokui Recipe Promote Treg cells differentiation and generation and inhibit 17 cells differentiation TNBS rat [104] Ulcerated enema Increase the number of Treg cells, upregulate IL-10, and reduce the number of 17 cells DSS mice [105] Abbreviations. Foxp3: forkhead-like protein 3; HIF-1α: hypoxia-inducible factor -1alpha; IL: interleukin; IDO1: indoleamine 2,3-dioxygenase 1; JAK2: Janus kinase-2; miR-675-5pa: microRNA-675-5pa; RORct: retinoic acid-related orphan receptor gamma t; STAT3: transcription protein 3; TGF; transforming growth factor; VDR: vitamin D receptor; TNF-α: tumor necrosis factor -alpha.…”

Section: Discussionmentioning

confidence: 99%

“…According to Tao Zhang's study, different doses of WCA had distinct effects on the mouse colon tissues' Treg/Th17 levels. To regulate both percentages and regain the proper balance between them, the therapeutic effect was obtained by upregulating Treg cell percentage and downregulating Th17 cell percentage [ 100 ]. Kaijieling (KJL) is a TCM formula preparation that can invigorate the spleen, clear away heat, and promote blood circulation.…”

Section: Chinese Medicine Treatment Strategy Of Balancing Regulation ...mentioning

confidence: 99%

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Traditional Chinese Medicine Regulates Th17/Treg Balance in Treating Inflammatory Bowel Disease

Xie

Xiong

Yilin

et al. 2022

Evidence-Based Complementary and Alternative Medicine

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Inflammatory bowel disease (IBD), also known as chronic nonspecific inflammatory disease of the colon and rectum, is primarily characterized by mucopurulent bloody stools, diarrhea, abdominal pain, and tenesmus. Its cause is uncertain. IBD patients frequently experience a high rate of recurrence, a protracted treatment course, and a high risk of carcinogenesis. Additionally, the difficulty of treatment is significantly increased by these illness characteristics. Currently, the normal treatment for this illness can lessen symptoms to some amount and even meet clinical treatment requirements, but due to serious side effects, unfavorable reactions, and high costs, we need to develop better complementary and alternative medicines. A number of studies have found that the imbalance of T helper cell 17 (Th17)/regulatory T cells (Treg) contributes significantly to the occurrence and progression of IBD and that Th17/Treg balance restoration is frequently useful in the management of IBD. As a result, regulating the Th17/Treg balance has also emerged as a novel approach to treating IBD. Traditional Chinese medicine (TCM) has gained popularity in recent years due to its advantages of low side effects, a variety of targets, and multiple regulatory mechanisms. A number of studies have shown that TCM can successfully intervene in the Th17/Treg imbalance and restore it, and research on the prevention and treatment of IBD by TCM by restoring Th17/Treg has also shown promising results. The characteristics of the Th17/Treg balance and its role in the pathogenesis of IBD, as well as the role of TCM in regulating the Th17/Treg imbalance, are analyzed. The research results are expected to provide a theoretical basis for the clinical treatment and pathology mechanism research of IBD.

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Section: Discussionmentioning

confidence: 99%

Section: Chinese Medicine Treatment Strategy Of Balancing Regulation ...mentioning

confidence: 99%

Traditional Chinese Medicine Regulates Th17/Treg Balance in Treating Inflammatory Bowel Disease

Xie

Xiong

Yilin

et al. 2022

Evidence-Based Complementary and Alternative Medicine

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“…However, few studies have reported on the mechanism of WCA in UC treatment. Only one study found that WCA improved the inflammatory response in dextran sodium sulfate-induced UC mice by regulating regulatory T cells and T helper 17 cells [16] .…”

Section: Introductionmentioning

confidence: 99%

Wei Chang An pill alleviates 2,4,6-trinitro-benzenesulfonic acid-induced ulcerative colitis by inhibiting epithelial-mesenchymal transition process

Wang

Chai

et al. 2023

Acupuncture and Herbal Medicine

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Objective: To investigate the inhibitory effect and mechanism of Wei Chang An pill (WCA) on ulcerative colitis (UC). Methods: A 2,4,6-trinitro-benzenesulfonic acid (TNBS)-induced UC model was established, and WCA was administered orally for 1 week. Body weight, colon length, disease activity index (DAI) score, and colon mucosa damage index (CMDI) score were recorded. Cytokine expression in lipopolysaccharide (LPS)-stimulated THP-1 cells was evaluated to determine the anti-inflammatory effects of WCA and its active ingredients. Immunohistochemistry and immunofluorescence were performed to detect the expression of epithelial-mesenchymal transition (EMT) markers E-cadherin and vimentin in rat UC and WCA groups, and in Caco-2 cells stimulated with conditioned medium (CM) from THP-1 cells, with or without LPS or WCA. Results: WCA significantly inhibited body weight loss, decreased DAI and CMDI scores, blocked colon length shortening, and improved histological damage in UC rats. Furthermore, both myeloperoxidase (MPO) activities and cytokine expression in UC tissues were significantly suppressed by WCA as well. In THP-1 cells, the mRNA expression of interferon-inducible protein (IP)-10, tumor necrosis factor-α (TNF-α), interleukin (IL)-6, and NF-κB inhibitor α (IκBα) was significantly suppressed by WCA and its active ingredients. E-cadherin expression in UC rats and CM-stimulated Caco-2 cells was downregulated and vimentin expression was upregulated, whereas both were blocked when administered with WCA. Conclusions: Our data showed that WCA alleviated UC progression by inhibiting inflammation-induced EMT progression. Graphical abstract: http://links.lww.com/AHM/A56

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The mechanisms of action of WeiChang'An Pill (WCAP) treat diarrhoea-predominant irritable bowel syndrome (IBS-D) using network pharmacology approach and in vivo studies

Chen

Chu

Lin

et al. 2021

Journal of Ethnopharmacology

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Mo1103 EFFECT OF WEICHANG'AN PILL ON TH17/TREG IMMUNE BALANCE IN MICE WITH ULCERATIVE COLITIS

Cited by 3 publications

References 0 publications

Traditional Chinese Medicine Regulates Th17/Treg Balance in Treating Inflammatory Bowel Disease

Traditional Chinese Medicine Regulates Th17/Treg Balance in Treating Inflammatory Bowel Disease

Wei Chang An pill alleviates 2,4,6-trinitro-benzenesulfonic acid-induced ulcerative colitis by inhibiting epithelial-mesenchymal transition process

The mechanisms of action of WeiChang'An Pill (WCAP) treat diarrhoea-predominant irritable bowel syndrome (IBS-D) using network pharmacology approach and in vivo studies

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