Mo1135 Trends in the Incidence of Esophageal Adenocarcinoma and Early Stage Esophageal Adenocarcinoma in the United States

Gamboa, Anthony; Kim, Sungjin; Woods, Kevin E.; Keilin, Steven; Cai, Qiang; Saba, Nabil F.; El‐Rayes, Bassel F.; Willingham, Field F.

doi:10.1016/s0016-5085(14)62051-5

Cited by 4 publications

(3 citation statements)

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“…The annual incidence of esophageal adenocarcinoma continues to increase in the United States, 1,2 and the rate of increase is greater than that of other major epithelial malignancies. 2,3 There also has been a relative increase in early-stage disease, possibly related to surveillance for Barrett esophagus. 4 The traditional treatment of choice for patients with early-stage esophageal adenocarcinoma has been esophagectomy with lymph node dissection.…”

Section: Introductionmentioning

confidence: 99%

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Treatment allocation in patients with early‐stage esophageal adenocarcinoma: Prevalence and predictors of lymph node involvement

Gamboa

Kim

Force

et al. 2016

Cancer

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BACKGROUND: In considering treatment allocation for patients with early esophageal adenocarcinoma, the incidence of lymph node metastasis is a critical determinant; however, this has not been well defined or stratified by the relevant clinical predictors of lymph node spread. METHODS: Data from the Surveillance, Epidemiology, and End Results database of the National Cancer Institute were abstracted from 2004 to 2010 for patients with early-stage esophageal adenocarcinoma. The incidence of lymph node involvement for patients with Tis, T1a, and T1b tumors was examined and was stratified by predictors of spread. RESULTS: A total of 13,996 patients with esophageal adenocarcinoma were evaluated. Excluding those with advanced, metastatic, and/or invasive (T2-T4) disease, 715 patients with Tis, T1a, and T1b tumors were included. .001]) were found to be independently associated with lymph node metastases. There was no lymph node spread noted with Tis tumors. For patients with low-grade (well or moderately differentiated) tumors measuring <2 cm in size, the risk of lymph node metastasis was 1.7% for T1a (P<.001) and 8.6% for T1b (P 5 .001) tumors. CONCLUSIONS: For patients with low-grade Tis or T1 tumors measuring 2 cm in size, the incidence of lymph node metastasis appears to be comparable to the mortality rate associated with esophagectomy. For highly selected patients with early esophageal adenocarcinomas, the results of the current study support the recommendation that local endoscopic resection can be considered as an alternative to surgical management when followed by rigorous endoscopic and radiographic surveillance. Cancer 2016;122:2150-7.

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Section: Introductionmentioning

confidence: 99%

“…The annual incidence of esophageal adenocarcinoma continues to increase in the United States, and the rate of increase is greater than that of other major epithelial malignancies . There also has been a relative increase in early‐stage disease, possibly related to surveillance for Barrett esophagus .…”

Section: Introductionmentioning

confidence: 99%

Treatment allocation in patients with early‐stage esophageal adenocarcinoma: Prevalence and predictors of lymph node involvement

Gamboa

Kim

Force

et al. 2016

Cancer

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“…With the growth speed greater than that of other dominating epithelial carcinomas, esophageal cancer (EC) ranks as the eighth-most common carcinoma and the sixth-most common cause of death worldwide, indicating that the overall prognosis remains dismal (1)(2)(3). Appropriate treatment is critical to patients' outcome.…”

Section: Introductionmentioning

confidence: 99%

A population-based investigation: How to identify high-risk T1-2N0 esophageal cancer patients?

Peng

Chen

et al. 2023

Front. Surg.

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PurposeNewly diagnosed T1-2N0 esophageal cancer (EC) is generally deemed as early local disease, with distant metastases (DM) easily overlooked. This retrospective study aimed to describe the metastatic patterns, identify risk factors and established a risk prediction model for DM in T1-2N0 EC patients.MethodsA total of 4623 T1-2N0 EC patients were identified in the Surveillance, Epidemiology and End Results (SEER) database from 2004 to 2018. Multivariable logistic regression was used to identify risk factors for DM. A nomogram was developed for presentation of the final model.ResultsOf 4623 T1-2N0 patients, 4062 (87.9%) had M0 disease and 561 (12.1%) had M1 disease. The most common metastatic site was liver (n = 156, 47.3%), followed by lung (n = 89, 27.0%), bone (n = 70, 21.2%) and brain (n = 15, 4.5%). Variables independently associated with DM included age at diagnosis, gender, tumor grade, primary site, tumor size and T stage. A nomogram based on the variables had a good predictive accuracy (area under the curve: 0.750). Independent risk factors for bone metastases (BoM), brain metastases (BrM), liver metastases (LiM) and lung metastases (LuM) were identified, respectively.ConclusionsWe identified independent predictive factors for DM, as well as for BoM, BrM, LiM and LuM. Above all, a practical and convenient nomogram with a great accuracy to predict DM probability for T1-2N0 EC patients was established.

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Role of Endoscopy in the Diagnosis, Staging, and Management of Esophageal Cancer

Clermont¹,

Willingham²

2019

Esophageal Cancer

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Mo1135 Trends in the Incidence of Esophageal Adenocarcinoma and Early Stage Esophageal Adenocarcinoma in the United States

Cited by 4 publications

References 0 publications

Treatment allocation in patients with early‐stage esophageal adenocarcinoma: Prevalence and predictors of lymph node involvement

Treatment allocation in patients with early‐stage esophageal adenocarcinoma: Prevalence and predictors of lymph node involvement

A population-based investigation: How to identify high-risk T1-2N0 esophageal cancer patients?

Role of Endoscopy in the Diagnosis, Staging, and Management of Esophageal Cancer

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