2014
DOI: 10.1016/s0016-5085(14)62110-7
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Mo1194 Anti-TNFα Therapies Are Safe During Pregnancy in Women With Inflammatory Bowel Disease: A Systematic Review and Meta-Analysis

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Cited by 20 publications
(26 citation statements)
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“…The present study builds on a previous meta-analysis by Narula et al 93 by the inclusion of two recent large studies 46,92 as well as comparison with population-based prevalence data. The inclusion of the most recent studies by Seirafi et al 46 and Diav-Citrin et al 92 contributed 26 and 49% of the weighting for APOs and CAs respectively, highlighting the importance of their contribution to this meta-analysis.…”
Section: Discussionmentioning
confidence: 99%
“…The present study builds on a previous meta-analysis by Narula et al 93 by the inclusion of two recent large studies 46,92 as well as comparison with population-based prevalence data. The inclusion of the most recent studies by Seirafi et al 46 and Diav-Citrin et al 92 contributed 26 and 49% of the weighting for APOs and CAs respectively, highlighting the importance of their contribution to this meta-analysis.…”
Section: Discussionmentioning
confidence: 99%
“…Thus, exposure during either planned or unintended pregnancy is considered a likely occurrence. Possible risks discussed after immunosuppressant therapy during pregnancy include teratogenicity, higher rates of spontaneous abortion, preterm birth, growth retardation and compromised fetal immunity [3,4]. Since all the approved TNF-α inhibitors are substances of high molecular weight, they are expected to require active transport to cross the human placenta.…”
Section: Introductionmentioning
confidence: 99%
“…Clinical experience is limited and varies widely between the five agents. In total, approximately 500 pregnancies exposed to TNF-α inhibitors have been published via registries, pharmacovigilance surveillance, case series [3,[5][6][7][8], and cohort studies [9,10]. Additionally a variety of case reports, abstracts and conference communications are available [1,11].…”
Section: Introductionmentioning
confidence: 99%
“…The long-term effects of in utero exposure to anti-TNF are not extensively explored. A recent study shows a normal health outcome and first year development in children exposed to anti-TNF, comparable to children of non-IBD controls [47] . Also preliminary results of 2 ongoing studies showed normal growth and development in anti-TNF exposed children in the first few years of life [48,49] .…”
Section: Anti-tnf Agentsmentioning
confidence: 85%