Mo1484 – The Association Between Primary Biliary Cholangitis and Ulcerative Colitis: Large Inpatient Database Study

Alsuleiman, Bayan; Sarmini, Muhammad Talal; Khoudari, George; Shah, Ravi S.; Romero‐Marrero, Carlos

doi:10.1016/s0016-5085(19)40325-9

Cited by 3 publications

(4 citation statements)

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“…Meanwhile, PBC contributes genetically to IBD and UC. These results were similar to the previous MR results 9 as well as conventional observations [38][39][40] . Compared to Zhang 9 , we conducted a study with larger sample sizes and achieved inconsistent estimates across the four statistical methods used.…”

Section: Discussionsupporting

confidence: 93%

Dissecting causal relationships between primary biliary cholangitis and extrahepatic autoimmune diseases based on Mendelian randomization

Ma,

Yang,

Wang

et al. 2024

Sci Rep

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As an autoimmune disease, up to 73% of patients with primary biliary cholangitis (PBC) have a combination of extrahepatic autoimmune diseases (EHAIDs); however, the causal relationship between PBC and EHAIDs is unclear. The genome-wide association analyses provided 14 GWAS data for PBC and EHAIDs, and bidirectional, two-sample MR analyses were performed to examine the relationship between PBC and EHAIDs. The analysis using MR provides a strong and meaningful estimation of the bidirectional correlation between PBC and 7 EHAIDs: rheumatoid arthritis, systemic lupus erythematosus, Sjögren's syndrome, systemic sclerosis, autoimmune hypothyroidism, inflammatory bowel disease and ulcerative colitis of its types. In addition, PBC increases the risk of autoimmune thyroid diseases such as autoimmune hyperthyroidism and Graves' disease, as well as multiple sclerosis and psoriasis. Additionally, PBC is identified as a risk factor for Crohn's disease and Celiac disease. Based on genetic evidence, there may be connections between PBC and specific EHAIDs: not all coexisting EHAIDs induce PBC, and vice versa. This underscores the significance of prioritizing PBC in clinical practice. Additionally, if any liver function abnormalities are observed during treatment or with EHAIDs, it is crucial to consider the possibility of comorbid PBC.

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Section: Discussionsupporting

confidence: 93%

Dissecting causal relationships between primary biliary cholangitis and extrahepatic autoimmune diseases based on Mendelian randomization

Ma,

Yang,

Wang

et al. 2024

Sci Rep

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“…10,11, Almost all studies were conducted in a single country, except for a study conducted in Korea, Malaysia, Vietnam, Thailand, and Myanmar. 79 Eighteen studies recruited only patients with UC, 11,[19][20][21]23,[25][26][27][28]31,40,42,44,45,57,60,68,70 and three only patients with CD. 30,37,39 No study recruited only patients with IBD-U, although three reported prevalence of PSC for patients with IBD-U separately.…”

Section: Resultsmentioning

confidence: 99%

“…When we considered UC, CD, or IBD-U separately, pooled prevalence of PSC was 2.47% (95% CI 1.92%-3.08%; I 2 =99.2%, p<0.0001) in 43 studies containing 566,178 patients with UC, 10,11,[19][20][21][22][23][24][25][26][27][28][29][31][32][33]36,[40][41][42]44,45,[47][48][49][50]52,[56][57][58][59][60][61]63,66,[68][69][70]72,74,[78][79][80] 0.96% (95% CI 0.69%-1.28%; I 2 =91.7%, p<0.0001) in 28 studies recruiting 156,943 patients with CD, 10,22,24,29,30,32,33,…”

Section: Pooled Prevalence Of Psc In Patients With Ibdmentioning

confidence: 99%

“…10,63,80 The OR in patients with UC, versus patients with CD, in 25 studies that reported prevalence in both UC and CD within the same study population, was 1.69 (95% CI 1.24-2.29), with moderate heterogeneity (I 2 =66.5%, p<0.0001), but no funnel plot asymmetry (Egger test, p=0.36). 10,22,24,29,32,33,36,41,[47][48][49][50]52,56,58,59,61,63,66,69,72,74,[78][79][80] In patients with IBD-U, versus UC, it was 3.27 (95% CI Seventeen studies reported data separately in patients with UC 11,19,45,47,49,50,56,57,60,63,66,69,70,72,74,78,80 and 13 in CD, 37,39,…”

Section: Pooled Prevalence Of Psc In Patients With Ibdmentioning

confidence: 99%

See 1 more Smart Citation

Prevalence of Primary Sclerosing Cholangitis in Patients With Inflammatory Bowel Disease: A Systematic Review and Meta-analysis

et al. 2021

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Dissecting causal relationships between primary biliary cholangitis and extrahepatic autoimmune diseases based on Mendelian randomization

Ma,

Yang,

Wang

et al. 2024

Preprint

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Background As an autoimmune disease, up to 73% of patients with primary biliary cholangitis (PBC) have a combination of extrahepatic autoimmune diseases (EHAIDs); however, the causal relationship between PBC and EHAIDs is unclear. Methods The genome-wide association analyses provided 14 GWAS data for PBC and EHAIDs, and bidirectional, two-sample MR analyses were performed to examine the relationship between PBC and EHAIDs. Results The analysis using MR provides a strong and meaningful estimation of the bidirectional correlation between PBC and 7 EHAIDs: rheumatoid arthritis, systemic lupus erythematosus, Sjögren's syndrome, systemic sclerosis, autoimmune hypothyroidism, inflammatory bowel disease and ulcerative colitis of its types. In addition, PBC increases the risk of autoimmune thyroid diseases such as autoimmune hyperthyroidism and Graves' disease, as well as multiple sclerosis and psoriasis. Additionally, PBC is identified as a risk factor for Crohn's disease and Celiac disease. Conclusion Based on genetic evidence, there may be connections between PBC and specific EHAIDs: not all coexisting EHAIDs induce PBC, and vice versa. This underscores the significance of prioritizing PBC in clinical practice. Additionally, if any liver function abnormalities are observed during treatment or with EHAIDs, it is crucial to consider the possibility of comorbid PBC.

show abstract

Mo1484 – The Association Between Primary Biliary Cholangitis and Ulcerative Colitis: Large Inpatient Database Study

Cited by 3 publications

References 0 publications

Dissecting causal relationships between primary biliary cholangitis and extrahepatic autoimmune diseases based on Mendelian randomization

Dissecting causal relationships between primary biliary cholangitis and extrahepatic autoimmune diseases based on Mendelian randomization

Prevalence of Primary Sclerosing Cholangitis in Patients With Inflammatory Bowel Disease: A Systematic Review and Meta-analysis

Dissecting causal relationships between primary biliary cholangitis and extrahepatic autoimmune diseases based on Mendelian randomization

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