Mo1503 IRRITABLE BOWEL SYNDROME SYMPTOMS IN NON-ALCOHOLIC FATTY LIVER DISEASE PATIENTS ARE AN INDICATOR OF DEPRESSION AND ANXIETY

Jones-Pauley, Michelle; Franco, Lissa; Tamimi, Omar; Nashatian, Leila; Victor, David W.; Quigley, Eamonn Martin

doi:10.1016/s0016-5085(20)34239-6

Cited by 2 publications

(6 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Importantly, our findings corroborate previous studies reporting a prevalence of IBS in patients with NAFLD of 29.2% and 29.4% respectively 14 , 15 . Our findings are also consistent with recent data suggesting that patients with NAFLD are significantly more likely to develop IBS than those without NAFLD 23 .…”

Section: Discussionsupporting

confidence: 92%

“…Indeed, our data do suggest that Rome IV IBS is associated with considerable morbidity with a significantly worse QoL, impaired ability to perform activities of daily living, and an increased incidence of severe anxiety and depression, compared to patients with NAFLD without IBS. This replicates findings from Jones-Pauley et al 14 and it is well documented that IBS is associated with increased levels of anxiety and depression 11 . Troublesome symptoms such as diarrhoea and incontinence can be distressing for patients and difficult to manage medically leading to frustration and a reduced QoL 9 , 27 .…”

Section: Discussionsupporting

confidence: 89%

“…Therefore, there has been interest in whether the two conditions co-exist in patient populations. Studies have previously suggested a higher prevalence of IBS in patients with NAFLD compared to global prevalence studies 14,15 . Although the studies have reported the incidence of IBS in NAFLD to be 30%, there have been significant heterogeneity in the diagnostic criteria used for both IBS and NAFLD as well as the populations studied 14,15 .…”

mentioning

confidence: 85%

“…Studies have previously suggested a higher prevalence of IBS in patients with NAFLD compared to global prevalence studies 14,15 . Although the studies have reported the incidence of IBS in NAFLD to be 30%, there have been significant heterogeneity in the diagnostic criteria used for both IBS and NAFLD as well as the populations studied 14,15 . Conversely, studies looking at the prevalence of NAFLD in patients with IBS have also shown a large variability in prevalence, between 3.7% and 74%, with the same disparities in diagnostic criteria usage 16,17 .…”

mentioning

confidence: 85%

See 3 more Smart Citations

The prevalence and burden of Rome IV bowel disorders of gut brain interaction in patients with non-alcoholic fatty liver disease: a cross-sectional study

Purssell

Bennett

Street

et al. 2023

Sci Rep

View full text Add to dashboard Cite

Rome IV bowel disorders of gut brain interaction (DGBI) and non-alcoholic fatty liver disease (NAFLD) are highly prevalent entities with overlapping pathophysiology and risk factors. We aimed to evaluate the prevalence and burden of Rome IV irritable bowel syndrome (IBS) in patients with NAFLD. Patients diagnosed with NAFLD were recruited from a specialist liver clinic. All participants completed assessments to determine liver fibrosis severity, including liver stiffness measurement (LSM), completed the Rome IV diagnostic questionnaire for bowel disorders of gut brain interaction, the IBS symptom severity score (IBS-SSS), and the EQ-5D-5L to measure of quality-of-life (QoL). 142 patients with NAFLD (71 (50%) female, mean age 53.5 (SD ± 14.9), BMI 35.2 (SD ± 8.1) kg/M2) were recruited. 79 (55.6%) patients met criteria for a Rome IV bowel DGBI, including 50 patients (35.2%) who met the criteria for IBS (mean IBS-SSS 277.2 (SD ± 131.5)). There was no difference in liver fibrosis scores between those with and without Rome IV IBS (FIB-4 scores p = 0.14, LSM p = 0.68). Patients with NAFLD and Rome IV IBS had significantly worse QoL scores (EQ-VAS p = 0.005 and EQ-5D-5L index p = 0.0007), impairment of usual activities of daily living (p = 0.012) and were more likely to report anxiety or depression (p = 0.038). Rome IV bowel DGBI such as IBS are highly prevalent in patients with NAFLD attending liver clinics and are associated with impaired QoL and psychosocial distress.

show abstract

Section: Discussionsupporting

confidence: 92%

Section: Discussionsupporting

confidence: 89%

mentioning

confidence: 85%

mentioning

confidence: 85%

See 2 more Smart Citations

The prevalence and burden of Rome IV bowel disorders of gut brain interaction in patients with non-alcoholic fatty liver disease: a cross-sectional study

Purssell

Bennett

Street

et al. 2023

Sci Rep

View full text Add to dashboard Cite

show abstract

“…Furthermore, Singh et al [ 21 ] studied 632 patients in India diagnosed with fatty liver disease and found that 29.4% had co-existing clinical features of IBS. Similar findings were reported by Jones-Pauley et al [ 22 ] in a cross sectional study looking at IBS diagnosed by Rome IV criteria in 130 NAFLD patients and as many as 38 (29.2%) patients had IBS based on Rome IV criteria. Interestingly, depression and anxiety were found to be more prevalent in the IBS cohort, compared to the non-IBS cohort, indicating the detrimental effect of co-existing bowel symptoms may have on quality of life, and the resulting need for a multi-systems approach in NAFLD patients with IBS symptoms.…”

Section: The Prevalence Of Co-existing Ibs and Nafldsupporting

confidence: 89%

Non-alcoholic fatty liver disease in irritable bowel syndrome: More than a coincidence?

Purssell¹,

Whorwell²,

Athwal³

et al. 2021

WJH

View full text Add to dashboard Cite

Irritable bowel syndrome (IBS) and non-alcoholic fatty liver disease (NAFLD) are amongst the most common gastrointestinal and liver conditions encountered in primary and secondary care. Recently, there has been interest in the apparent co-incidence of NAFLD in patients with IBS mainly driven by improved understanding of their shared risk factors and pathophysiology. In this paper we summarize the shared risk factors which include; overlapping nutritional and dietary factors as well as shared putative mechanisms of pathophysiology. These include changes in the gut microbiome, gut permeability, immunity, small bowel bacterial overgrowth and bile acid metabolism. This paper describes how these shared risk factors and etiological factors may have practical clinical implications for these highly prevalent conditions. It also highlights some of the limitations of current epidemiological data relating to estimates of the overlapping prevalence of the two conditions which have resulted in inconsistent results and, therefore the need for further research. Early recognition and management of the overlap could potentially have impacts on treatment outcomes, compliance and morbidity of both conditions. Patients with known IBS who have abnormal liver function tests or significant risk factors for NAFLD should be investigated appropriately for this possibility. Similarly, IBS should be considered in patients with NAFLD and symptoms of abdominal pain associated with defecation, an altered bowel habit and bloating.

show abstract

Mo1503 IRRITABLE BOWEL SYNDROME SYMPTOMS IN NON-ALCOHOLIC FATTY LIVER DISEASE PATIENTS ARE AN INDICATOR OF DEPRESSION AND ANXIETY

Cited by 2 publications

References 0 publications

The prevalence and burden of Rome IV bowel disorders of gut brain interaction in patients with non-alcoholic fatty liver disease: a cross-sectional study

The prevalence and burden of Rome IV bowel disorders of gut brain interaction in patients with non-alcoholic fatty liver disease: a cross-sectional study

Non-alcoholic fatty liver disease in irritable bowel syndrome: More than a coincidence?

Contact Info

Product

Resources

About