“…Combination therapy should be a preferred strategy in patients with risk factors for disabling disease, complications or surgery. Risk factors in CD include young age at diagnosis, current tobacco use, perianal disease, small bowel involvement and multiple extraintestinal manifestations [17][18][19]. Combination therapy is the preferred strategy in ulcerative colitis patients requiring hospitalization at diagnosis, younger age at diagnosis, with derangements in laboratories such as sedimentation rate, and extensive colitis [20,21].…”