Mo1926 PROBIOTICS FOR THE PREVENTION OF CLOSTRIDIUM DIFFICILE INFECTION AMONG PATIENTS UNDERGOING ANTIBIOTIC THERAPY

Popescu, A; Foncea, Camelia; Lupușoru, Raluca; Topan, M; Cotrău, Radu; Moga, Tudor; Belintan, Andrada-Patricia; Dănilă, Mirela; Şirli, Roxana; Sporea, Ioan

doi:10.1016/s0016-5085(20)33123-1

Cited by 1 publication

(8 citation statements)

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“…Seven of which were journal articles and three of which were conference abstracts. For the 10 clinical trials, there were a total of 14 treatment arms which were included (10)(11)(12)(13)(14)(15)(16)(17)(18)(19). Most of the studies included were from peer-reviewed, full text articles (n= 7, 70%), but three (n = 3, 30%) were only available as meeting abstracts.…”

Section: Included Trialsmentioning

confidence: 99%

“…Two of the studies (20%) were unblinded. One of which contained intensive care unit patients (16) and therefore these patients are not aware of what is being administered to them and the second study included patients that were admitted to the gastroenterology department (17).…”

Section: Degree Of Blindingmentioning

confidence: 99%

“…The ages of the patients enrolled in the ten trials range from 3 months to 84 years of age. Most of the trials enrolled adult populations however 3 (30%) trials involved elderly patients with a mean population age  65 years of age (11,13,17). Two trials (20%) included patients from pediatric populations (15,19).…”

Section: Patient Populationmentioning

confidence: 99%

“…The probiotic dosage range varied from 1.00E+08 colony forming unites (CFUs) to 4.50E+11 CFUs. Only one trial did not specify the dosage of probiotic used as an intervention (17). Duration of follow-up varied from 21 days to 8 weeks, three studies, all of which were abstracts, did not specify the duration of follow-up (10,17,19).…”

Section: Probiotics In CDI Prevention Trialsmentioning

confidence: 99%

“…Only one trial did not specify the dosage of probiotic used as an intervention (17). Duration of follow-up varied from 21 days to 8 weeks, three studies, all of which were abstracts, did not specify the duration of follow-up (10,17,19). None of the trials reported negative safety outcomes with probiotics as an intervention treatment.…”

Section: Probiotics In CDI Prevention Trialsmentioning

confidence: 99%

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Use of Probiotics in the Prevention of Clostridioides difficile Infections during Antibiotic Exposure: A Systematic Review and Meta-Analysis

Dabrowski

2023

Preprint

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Clostridioides difficileinfections are a growing concern in the hospital setting. Current prevention methods include infection control strategies, antibiotic stewardship, and proper hand hygiene. However, the occurrence ofC. difficilestill manages to cause nosocomial outbreaks especially in vulnerable populations. Probiotics have been historically questioned for their use in the prevention of antibiotic-associated diarrhea and more specifically,C. difficileinfections.This meta-analysis pools 10 randomized controlled trials for the prevention ofClostridioides difficileinfections (CDI) from reviewing the Cochrane Central Register of Controlled Trials (CENTRAL).A prioriinclusion criteria remained as follows: RCTs, blinded/open trials, all populations, articles, or conference abstracts. Exclusion criteria excluded publications published outside 2013-2023*, non-English language trials, pre-clinical trials/protocols, case reports/series/systematic reviews, duplicates, probiotics not specified in methods, non-RCTs, incomplete/no outcomes reported, no confirmation ofClostridioides difficileinfection. Probiotic strains tested in these trials mainly includedLactobacillus spp. and Bifidobacterium spp. Some studies showed significant benefits while others did not find significant improvement in the prevention ofC. difficileinfections.The meta-analysis suggests that probiotics may have a positive effect in preventing CDI during antibiotic treatment. The study results had large levels of statistical heterogeneity which indicates an argument for further large-scale research to provide more definitive evidence on the efficacy of probiotics in CDI prevention.

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Section: Included Trialsmentioning

confidence: 99%

Section: Degree Of Blindingmentioning

confidence: 99%

Section: Patient Populationmentioning

confidence: 99%

Section: Probiotics In CDI Prevention Trialsmentioning

confidence: 99%

Section: Probiotics In CDI Prevention Trialsmentioning

confidence: 99%

See 3 more Smart Citations

Use of Probiotics in the Prevention of Clostridioides difficile Infections during Antibiotic Exposure: A Systematic Review and Meta-Analysis

Dabrowski

2023

Preprint

View full text Add to dashboard Cite

show abstract

Mo1926 PROBIOTICS FOR THE PREVENTION OF CLOSTRIDIUM DIFFICILE INFECTION AMONG PATIENTS UNDERGOING ANTIBIOTIC THERAPY

Cited by 1 publication

References 0 publications

Use of Probiotics in the Prevention of Clostridioides difficile Infections during Antibiotic Exposure: A Systematic Review and Meta-Analysis

Use of Probiotics in the Prevention of Clostridioides difficile Infections during Antibiotic Exposure: A Systematic Review and Meta-Analysis

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