MO391: Association Between Skeletal Muscle and Level of Physical Activity in Patients With Chronic Kidney Disease: A Cross-Sectional Analysis of the Peaking Cohort

Abstract

BACKGROUND AND AIMS Favorable skeletal muscles have been associated with higher physical activity (PA) in the general population. However, little is known regarding this relationship in a population of Chinese chronic kidney disease (CKD) patients. The aim of this study is to investigate the relationship between PA and skeletal muscle in Chinese non-dialysis CKD patients. METHOD This was a cross-sectional analysis of the PEAKING cohort—an open cohort aimed to explore the effect of PA on health-related outcomes in the Chinese non-dialysis CKD population from 2017. The PA of patients was assessed by wearing an accelerometer (ActiGraph) for 9 consecutive days. The levels of PA were classified into four categories (no PA, low, moderate and high level of PA) according to the 2008 U.S. Physical Activity Guidelines. The information of skeletal muscles was evaluated by Biospace Inbody 770 within 180 days after the enrollment. Multivariate linear analysis was conducted to investigate the association between PA and skeletal muscle, adjusted for age, sex, CKD stages, smoking and drinking status, drug use and complications. RESULTS A total of 104 non-dialysis CKD patients (median age 49.6 years, 48% female, 49% with CKD stage 3 or above) were enrolled in this study. None of the included CKD patients had no or low-level PA while 42 (40%) patients had moderate and 62 (60%) had high-level PA. Multivariate linear regression showed that there was no significant association between skeletal muscle and level of PA (B = 0.07, 95% CI −0.58, 2.01; P = 0.279). CONCLUSION Higher-level PA was not significantly associated with more skeletal muscle mass. Further work examining the relationship between skeletal muscle and level of PA needs to be done in a larger sample of non-dialysis CKD patients.