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Luber, Andreas

doi:10.1007/978-3-322-81778-5

Cited by 3 publications

(4 citation statements)

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“…Quantification settings were as follows: re-quantify with a second peak finding attempt after protein identification has completed; match full MS1 peaks between runs; a 0.7 min retention time match window was used after an alignment function was found with a 20 min retention time search space. The label free quantitation (LFQ) normalization algorithm in MaxQuant 34,35 was used for protein quantitation. The quantitation method only considered razor and unique peptides for protein level quantitation.…”

Section: Maxquant For Label-free Proteome Quantificationmentioning

confidence: 99%

Specific Proteomes of Hippocampal Regions CA2 and CA1 Reveal Proteins Linked to the Unique Physiology of Area CA2

et al. 2019

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The hippocampus is well established as an essential brain center for learning and memory. Within the hippocampus, recent studies show that area CA2 is important for social memory, and is an anomaly compared to its better understood neighboring region, CA1. Unlike CA1, CA2 displays a lack of typical synaptic plasticity, enhanced calcium buffering and extrusion, and resilience to cell death following injury. Although recent studies have identified multiple molecular markers of area CA2, the proteins that mediate the unique physiology, signaling, and resilience of this region are unknown. Using a transgenic GFP-reporter mouse line that expresses eGFP in CA2, we were able to perform targeted dissections of area CA2 and CA1 for proteomic analysis. We identified over 100 proteins with robustly enriched expression in area CA2 compared to CA1. Many of these proteins, including RGS14 and NECAB2 have already been shown to be enriched in CA2 and important for its function, while many more merit further study in the context of enhanced expression in this enigmatic brain region. Furthermore, we performed a comprehensive analysis of the entire data set (>2300 proteins) using a weighted protein co-expression network analysis (WPCNA). This identified eight distinct co-expressed patterns of protein co-enrichment associated with increased expression in area CA2 tissue (compared to CA1). The novel data set we present here reveals a specific CA2 hippocampal proteome, laying the groundwork for future studies and a deeper understanding of area CA2 and the proteins mediating its unique physiology and signaling.

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Section: Maxquant For Label-free Proteome Quantificationmentioning

confidence: 99%

Specific Proteomes of Hippocampal Regions CA2 and CA1 Reveal Proteins Linked to the Unique Physiology of Area CA2

et al. 2019

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“…The CDC has presented a very good illustration of the impact of climate change on Human Health in the following Figure 3 [4].…”

Section: Highlighting the Interrelationships Between Health Biodiversity And Ecosystemsmentioning

confidence: 99%

“…1850 [4]. Long-term changes in temperature and precipitation are often accompanied by heat waves and intense rainfall, increasing the risk of flooding [5], mainly in countries in the Caribbean region such as Haiti.…”

Section: Introductionmentioning

confidence: 99%

Vector-Borne Diseases and Climate Change in the Environmental Context in Haiti

Balthazard-Accou¹,

Millien²,

Michel³

et al. 2021

Environmental Health

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Climate change is one of the main challenges facing many countries, particularly developing countries, because of its negative impact on their various ecosystems and their socio-economic development, which very often leads them down a slow descent into poverty. This is because climate change can manifest itself in different forms such as climate variability and extreme events (droughts, epidemics, floods, storms and hurricanes), which can affect biodiversity and cause many human and animal diseases and deaths. In fact, the evolution of ecosystems is dependent on climate and environmental change and appears to be closely associated with many emerging or re-emerging diseases. In general, the ecosystems considered to be most exposed to climate change are those located in and around the intertropical convergence zone in particular. They are believed to be closely linked to the occurrence of several emerging diseases, particularly vector-borne diseases. For years, the Republic of Haiti has been experiencing the adverse effects of these global changes with a marked disruption of its rainfall pattern and prolonged periods of drought as well as a pronounced increase in temperatures even in high altitude areas. Although there is evidence that climate change is increasing the frequency of vector-borne diseases and may contribute to increasing the virulence of their pathogens, there are very few studies conducted in Haiti on the relationship between climate change and vector-borne diseases. The purpose of this chapter is to define the interrelationships between climate change and vector-borne diseases in Haiti by identifying avenues of research to better understand the effects of climate change on public health and to make appropriate recommendations to decision-makers to ensure proper management.

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“…Urban Heat Island (Urban Heat Island) refers to the phenomenon that in the process of urbanisation, the temperature in the city centre increases and the temperature in the urban area is higher than that in the suburbs due to the increase in population density, changes in the urban form, and the emission of heat sources for production and living. [1][2] Heat Island The heat island effect not only changes the ecological environment of the area, but also negatively affects the quality of urban water, air quality and residents' health. [3] At the same time, the increase of impermeable layer coverage will lead to hot summer and cold winter in the urban area, which will reduce the livability of the city.…”

Section: Introductionmentioning

confidence: 99%

Characteristics of urban surface heat field differentiation and analysis of influencing factors

YANG,

ZHANG

2024

Fifth International Conference on Geology, Mapping, and Remote Sensing (ICGMRS 2024)

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Taking 8 major provincial capital cities and municipalities such as Changchun and Shanghai as the research objects, based on the Landsat8 L1 product in 2022-2023, we use the atmospheric correction method to carry out the inversion of summer and winter surface temperatures in the target urban administrative areas, and analyse the characteristics of the urban surface heat field differentiation; using SPSS, the data are analysed through stepwise regression, and the coupling between the urban heat field and the influencing factors is explored. The data were analysed by stepwise regression using SPSS to explore the coupling between urban thermal field and influencing factors. The results show that: ① the summer temperature between the east and west cities is lower in the east and higher in the west, and the temperature between the cities of similar latitude tends to be the same in winter; the temperature difference between the north and south cities is significant, which is more prominent in winter. ② The temperature in the city centre is higher than that in the suburbs in summer, the near-water area is lower than that in the far-water area, the cooling effect of the water system decreases with the decrease of latitude, and the temperature in the city centre is significantly lower than that in the outside in winter, except for Lhasa and Changchun. (iii) The eight independent variables in the summer model explain 69.8% of the summer urban heat field divergence characteristics, and the seven independent variables in the winter model explain 70.8% of the winter urban heat field divergence characteristics. In summer, the temperature decreases by 0.02℃ for every 1m increase in height, 0.003℃ for every 1km² increase in impermeable layer area, and 0.001℃ for every 1km² increase in water body area. In winter, the temperature increases by 0.01℃ for every 1 person/km² increase in population density, 0.05℃ for every 1km² increase in water body area, and 0.05℃ for every 1km² increase in vegetation cover area. 1km², the temperature decreases by 0.0125℃. in order to provide theoretical support for the study of urban heat field.

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Mobile Brokerage

Cited by 3 publications

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Specific Proteomes of Hippocampal Regions CA2 and CA1 Reveal Proteins Linked to the Unique Physiology of Area CA2

Specific Proteomes of Hippocampal Regions CA2 and CA1 Reveal Proteins Linked to the Unique Physiology of Area CA2

Vector-Borne Diseases and Climate Change in the Environmental Context in Haiti

Characteristics of urban surface heat field differentiation and analysis of influencing factors

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