“…On the basis of the mapped literature, the nature, content, and structure of digital therapeutics are major determinants of their uptake and effectiveness across countries [ 1 , 4 , 13 , 19 , 40 , 63 , 100 , 102 , 189 , 191 - 194 , 200 , 205 , 230 , 246 , 265 , 266 ]. The design of digital therapeutics needs to be driven by the needs and expectations of patients [ 56 , 61 , 66 , 68 , 84 , 100 , 102 , 117 , 118 , 122 , 132 , 136 , 140 , 141 , 168 , 177 , 189 , 191 - 194 , 200 , 202 , 208 , 214 - 216 , 221 , 230 , 233 , 250 , 266 , 273 , 274 ] while acknowledging that patient needs may shift with time and disease progression [ 140 ]. They need to have clear aims and a position in the health care pathway that is understood by patients and professionals, with comprehensive and trusted information provided about the qualities and services of the devices and targeted health condition [ 56 , 57 , 93 , 118 , 142 , 174 , 177 , 178 , …”