This chapter presents the overview of global health literacy, the advances issues of global health literacy, global health literacy and the internet utilization, global health literacy and disease management, and global health literacy and diabetes. Global health literacy is the important subject that is related to the individual's ability to understand and manage any healthcare issue. Global health literacy should be enhanced through healthcare providers and healthcare organizations. Global health literacy can help people prevent their health problems, protect their health, and manage their healthcare problems in a timely and effective manner. People who understand health instructions usually make fewer mistakes when taking medicine or preparing for the medical procedures toward the reduction of medical errors in global healthcare.