2014
DOI: 10.1103/physrevlett.113.128303
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Mobile Linkers on DNA-Coated Colloids: Valency without Patches

Abstract: Colloids coated with single-stranded DNA (ssDNA) can bind selectively to other colloids coated with complementary ssDNA. The fact that DNA-coated colloids (DNACCs) can bind to specific partners opens the prospect of making colloidal "molecules." However, in order to design DNACC-based molecules, we must be able to control the valency of the colloids, i.e., the number of partners to which a given DNACC can bind. One obvious, but not very simple approach is to decorate the colloidal surface with patches of singl… Show more

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Cited by 86 publications
(146 citation statements)
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“…Controlled valence of isotropic mesoscale particles has been demonstrated (18,32). The interaction among monomers needs to strengthen in time, so that they do not aggregate in solution, but do bind to each other during time they are attached to the template.…”
Section: Discussionmentioning
confidence: 99%
“…Controlled valence of isotropic mesoscale particles has been demonstrated (18,32). The interaction among monomers needs to strengthen in time, so that they do not aggregate in solution, but do bind to each other during time they are attached to the template.…”
Section: Discussionmentioning
confidence: 99%
“…Linkers on particles B i can form inter-particle bridges b i , with particles A. In the following, we consider linkers constituted by double stranded DNA spacers of length L = 10 nm and point-like sticky ends, 21 rigid particles of radius R = 10 L, 21 and N = 100. See Sec.…”
Section: Binding Cooperativity In Dna-functionalized Particlesmentioning
confidence: 99%
“…Our results are exact in the limit of many linkers per particle. 21,22 We envisage applications of our theory to the association of more complex molecules like DNA tiles [23][24][25] or virial caspids. 26 In Sec.…”
Section: Introductionmentioning
confidence: 99%
“…Looked from another perspective, this can be rationalised as a weaker effective ligand-receptor bond strength, due to the entropic penalty of localising the pair inside the patch area. 53 Surface functionalisation of nanoparticles is used not only to graft targeting ligands, but also to protect their surface. For example, dense brushes of poly-ethylene-glycol (PEG), a highly bio-inert polymer, are often used to prevent the adsorption of serum protein and to reduce the non-specific uptake of nanoparticles by macrophages.…”
Section: Predicting and Controlling Nanoparticles Endocytosismentioning
confidence: 99%