Mobile phone-based biosensing: An emerging “diagnostic and communication” technology

Quesada-González, Daniel; Merkoçi, Arben

doi:10.1016/j.bios.2016.10.062

Cited by 227 publications

(113 citation statements)

References 84 publications

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“…[10] The combination of nanotechnology with point of care diagnostics has resulted in significant advances in device technology. [11–13] Nanomaterials possess unique material and size dependent properties that can enhance LFA detection by optical as well as fluorescent, spectroscopic, and electrochemical readouts. These advances can help create lower-cost, higher sensitivity, and field-forward devices.…”

Section: Lateral Flow Diagnostics Are Enhanced By Nanotechnologymentioning

confidence: 99%

Challenges of the Nano–Bio Interface in Lateral Flow and Dipstick Immunoassays

Puig

Bosch²,

Gehrke

et al. 2017

Trends in Biotechnology

102

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Lateral flow assays (LFAs) are highly attractive for point of care diagnostics for infectious disease, food safety, and many other medical uses. The unique optical, electronic and chemical properties that arise from the nanostructured and material characteristics of nanoparticles provide an opportunity to increase LFA sensitivity and impart novel capabilities. However, interfacing to nanomaterials in complex biological environments is challenging and can result in undesirable side effects such as non-specific adsorption, protein denaturation, and steric hindrance. These issues are even more acute in LFAs, where there are many different types of inorganic-biological interfaces, often of complex nature. Therefore, the unique properties of nanomaterials for LFAs must be exploited in a way that addresses these interface challenges.

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Section: Lateral Flow Diagnostics Are Enhanced By Nanotechnologymentioning

confidence: 99%

Challenges of the Nano–Bio Interface in Lateral Flow and Dipstick Immunoassays

Puig

Bosch²,

Gehrke

et al. 2017

Trends in Biotechnology

102

View full text Add to dashboard Cite

show abstract

“…Since their development in 1992 and first use as analytical devices in 2008, smartphones have already been used as sensors, for light microscopy, single-molecule microscopy, cell imaging, bacteria detection, colorimetric detection, enzyme linked immunosorbent assay (ELISA), and lateral flow immunoassays (LFIA), which exemplifies their capabilities as detectors in rapid diagnostics [12, 17–26] . For an in-depth review into all existing smartphone-based diagnostic devices, Quesada-Gonzalez and Merkoçi can be referred to [27]. For a more focused review concerning biosensors and bioelectronics on a smartphone see Zhang and Liu [28].…”

Section: Introductionmentioning

confidence: 99%

Consumer-friendly food allergen detection: moving towards smartphone-based immunoassays

2018

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In this critical review, we provide a comprehensive overview of immunochemical food allergen assays and detectors in the context of their user-friendliness, through their connection to smartphones. Smartphone-based analysis is centered around citizen science, putting analysis into the hands of the consumer. Food allergies represent a significant worldwide health concern and consumers should be able to analyze their foods, whenever and wherever they are, for allergen presence. Owing to the need for a scientific background, traditional laboratory-based detection methods are generally unsuitable for the consumer. Therefore, it is important to develop simple, safe, and rapid assays that can be linked with smartphones as detectors to improve user accessibility. Smartphones make excellent detection systems because of their cameras, embedded flash functions, portability, connectivity, and affordability. Therefore, this review has summarized traditional laboratory-based methods for food allergen detection such as enzyme-linked-immunosorbent assay, flow cytometry, and surface plasmon resonance, and the potential to modernize these methods by interfacing them with a smartphone readout system, based on the aforementioned smartphone characteristics. This is the first review focusing on smartphone-based food-allergen detection methods designed with the intention of being consumer-friendly. Graphical abstractA smartphone-based food allergen detection system in three easy steps (1) sample preparation, (2) allergen detection on a smartphone using antibodies, which then transmits the data wirelessly, (3) analytical results sent straight to smartphone Electronic supplementary materialThe online version of this article (10.1007/s00216-018-0989-7) contains supplementary material, which is available to authorized users.

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“…Smartphone-based electrochemical instruments for health monitoring are in vogue among the scientific community in the recent years, promising portable, real-time, cloud-connected and inexpensive measurements capable of basic potentiostatic operation, chronoamperometry (CA), cyclic voltammetry (CV), electrochemical impedance spectroscopy (EIS) (Aggidis et al, 2015;Quesada-González and Merkoçi, 2017;Roda et al, 2016;Zhang and Liu, 2016). Cost is an important parameter of these solutions when penetration in the market is considered in the near future, and it is generally determined by the number of discrete components used to link the transducer electrodes to the computational power of a smartphone:…”

Section: Introductionmentioning

confidence: 99%