Mobile phone induced cognitive and neurochemical consequences

Sharma, Anjali; Sharma, Samta; Shrivastava, Sadhana; Singhal, P. K.; Shukla, Sangeeta

doi:10.1016/j.jchemneu.2019.101684

Cited by 15 publications

(7 citation statements)

References 38 publications

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“…Most recent animal studies evaluated the genotoxicity of cell phone radiation to brain in rats and mice. Results from these studies suggest that cell phone radiation could lead to DNA damage (Sharma et al 2019;Smith-Roe et al 2020;Alkis, Bilgin, et al 2019) and these findings are in line with our results. Previous epidemiological studies also linked mobile phone radiation with the occurrence of glioma (Wang et al 2018).…”

Section: Discussionsupporting

confidence: 91%

“…The calls were made 3 times a day, 2 h each time, with 1-hour break between the calls; 6 consecutive days followed by one day break per week. The exposure time was determined based on previously publications (Nisbet et al 2016;Bedir et al 2018;Sharma et al 2019). At the end of 16-week experiment, all rabbits were sacrificed and organs were isolated.…”

Section: Experimental Designmentioning

confidence: 99%

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The toxic effect of mobile phone radiation on rabbit organs

Zhu

Zhu²,

et al. 2020

All Life

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Whether electromagnetic radiation (EMR) emitted from mobile phones is hazardous to human health is largely unknown. We investigated the effects of mobile phone radiation on critical organs in a rabbit model by exposing the animals to mobile phone radiation with sub-thermal specific absorption rate (SAR) of 1.0 and 0.7 W/kg for the head and the body, respectively, for 16 weeks (6 h/day, 6 days/week). There is no apparent change at the organ level. However, H&E staining showed that radiation-exposure significantly increased inflammatory cell infiltration in the liver and the lungs with a lesser degree of myocardial cell cytoplasmic vacuolation. In addition, results from γ-H2AX staining suggest that radiation can also cause DNA damage in the brain. Of note, no apparent activation of Caspase-3 in the organs examined. Our data altogether suggest that mobile phone radiation may be more hazardous to both the liver and the lungs, and less toxic to the brain and heart.

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Section: Discussionsupporting

confidence: 91%

Section: Experimental Designmentioning

confidence: 99%

The toxic effect of mobile phone radiation on rabbit organs

Zhu

Zhu²,

et al. 2020

All Life

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“…TUNEL staining is a method to detect apoptosis and can be used to distinguish apoptosis from necrosis [Sharma et al, 2013]. A small number of TUNEL‐positive neurons and neuroglia cells were observed in the cortex and hippocampal regions of the cage‐control, control, melatonin, and sham melatonin groups (Figs.…”

Section: Resultsmentioning

confidence: 99%

“…Similar observations were found by some researchers; Motawi et al [2014] found that 900 MHz RFR exposure (60 days, 2 h/day, SAR: 1.13 W/kg) induced apoptosis and caused oxidative changes and neuronal damage. Sharma et al [2019] demonstrated that 2,100 MHz RFR (3 weeks, 5 days/week, 4 h/day, SAR = 0.445 W/kg) exposure induced oxidative stress, caused degeneration in brain tissue, and affected the cognitive functions of rats. Kamali et al [2018] pointed out that 2.45 GHz RFR (Wi-Fi) exposure (10 weeks, 24 h/day) decreased the activity of some antioxidant enzymes (CAT, GSH-Px, SOD), but GSH and TBARS levels were not affected by the exposure.…”

Section: Discussionmentioning

confidence: 99%

Effects of 2600 MHz Radiofrequency Radiation in Brain Tissue of Male Wistar Rats and Neuroprotective Effects of Melatonin

Sirav

Oruç

et al. 2021

Bioelectromagnetics

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The debate on the biological effects of radiofrequency radiation (RFR) still continues due to differences in the design of studies (frequency, power density, specific absorption rate [SAR], exposure duration, cell, tissue, or animal type). The current study aimed to investigate the effects of 2,600 MHz RFR and melatonin on brain tissue biochemistry and histology of male rats. Thirty-six rats were divided into six groups randomly: cage-control, sham, RFR, melatonin, sham melatonin, and RFR melatonin. In RFR groups, animals were exposed to 2,600 MHz RFR for 30 days (30 min/day, 5 days/week) and the melatonin group animals were subcutaneously injected with melatonin (7 days/week, 10 mg/kg/day) for 30 days. SAR in brain gray matter was calculated as 0.44 and 0.295 W/kg for 1 and 10 g averaging, respectively. RFR exposure decreased the GSH, GSH-Px, and SOD levels and increased the MPO, MDA, and NOx levels (P < 0.005) significantly. RFR exposure also led to an increase in structural deformation and apoptosis in the brain tissue. This study revealed that exogenous high-dose melatonin could reduce these adverse effects of RFR. Limiting RFR exposure as much as possible is recommended, and taking daily melatonin supplements may be beneficial. Bioelectromagnetics.

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“…The mechanisms by which radiofrequency radiation affects cells, tissues, and organisms are not well understood and may include diverse processes such as inhibition of the mitotic spindle apparatus leading to impaired cell division and cell death [22], changes in the activity of voltage-gated calcium channels [23][24][25][26], changes in the concentrations of reactive oxygen species and redox homeostasis [25,[27][28][29][30][31][32], changes in intracellular enzymes and gene expression [33], and changes in membrane permeability [34]. DNA damage following exposure to RFR [35,36] may be a direct effect or due to secondary mechanisms, such as interference with DNA repair processes [37].…”

Section: Introductionmentioning

confidence: 99%

Development of health-based exposure limits for radiofrequency radiation from wireless devices using a benchmark dose approach

Uche

Naidenko

2021

Environ Health

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Background Epidemiological studies and research on laboratory animals link radiofrequency radiation (RFR) with impacts on the heart, brain, and other organs. Data from the large-scale animal studies conducted by the U.S. National Toxicology Program (NTP) and the Ramazzini Institute support the need for updated health-based guidelines for general population RFR exposure. Objectives The development of RFR exposure limits expressed in whole-body Specific Absorption Rate (SAR), a metric of RFR energy absorbed by biological tissues. Methods Using frequentist and Bayesian averaging modeling of non-neoplastic lesion incidence data from the NTP study, we calculated the benchmark doses (BMD) that elicited a 10% response above background (BMD10) and the lower confidence limits on the BMD at 10% extra risk (BMDL10). Incidence data for individual neoplasms and combined tumor incidence were modeled for 5% and 10% response above background. Results Cardiomyopathy and increased risk of neoplasms in male rats were the most sensitive health outcomes following RFR exposures at 900 MHz frequency with Code Division Multiple Access (CDMA) and Global System for Mobile Communications (GSM) modulations. BMDL10 for all sites cardiomyopathy in male rats following 19 weeks of exposure, calculated with Bayesian model averaging, corresponded to 0.27–0.42 W/kg whole-body SAR for CDMA and 0.20–0.29 W/kg for GSM modulation. BMDL10 for right ventricle cardiomyopathy in female rats following 2 years of exposure corresponded to 2.7–5.16 W/kg whole-body SAR for CDMA and 1.91–2.18 W/kg for GSM modulation. For multi-site tumor modeling using the multistage cancer model with a 5% extra risk, BMDL5 in male rats corresponded to 0.31 W/kg for CDMA and 0.21 W/kg for GSM modulation. Conclusion BMDL10 range of 0.2—0.4 W/kg for all sites cardiomyopathy in male rats was selected as a point of departure. Applying two ten-fold safety factors for interspecies and intraspecies variability, we derived a whole-body SAR limit of 2 to 4 mW/kg, an exposure level that is 20–40-fold lower than the legally permissible level of 0.08 W/kg for whole-body SAR under the current U.S. regulations. Use of an additional ten-fold children’s health safety factor points to a whole-body SAR limit of 0.2–0.4 mW/kg for young children.

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Mobile phone induced cognitive and neurochemical consequences

Cited by 15 publications

References 38 publications

The toxic effect of mobile phone radiation on rabbit organs

The toxic effect of mobile phone radiation on rabbit organs

Effects of 2600 MHz Radiofrequency Radiation in Brain Tissue of Male Wistar Rats and Neuroprotective Effects of Melatonin

Development of health-based exposure limits for radiofrequency radiation from wireless devices using a benchmark dose approach

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