Mobile phones electromagnetic radiation and NAD+-dependent isocitrate dehydrogenase as a mitochondrial marker in asthenozoospermia

Hagras, Abeer M.; Toraih, Eman A.; Fawzy, Manal S.

doi:10.1016/j.biopen.2016.07.003

Cited by 14 publications

(5 citation statements)

References 33 publications

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“…According to the authors, the depolarization of the mitochondrial membrane could be the trigger for the ROS generation which in turn caused the DNA breaks observed in exposed mice. In a case-control study, Hagras et al [ 156 ] found that patients with prolonged cell phone use (>4 h daily) showed a significant imbalance in sperm motility. In the same work, it was revealed that mitochondrial isoenzyme NAD + -dependent isocitrate dehydrogenase (IDH) activity was increased in the seminal plasma of exposed patients.…”

Section: Emf Effects In Male Reproductive System and Fertilitymentioning

confidence: 99%

“…The role of mitochondria as one of the main targets of ELF- and RF-EMF exposure has emerged, especially in the male reproductive system. Indeed, these radiations seem to directly target the electron transport chain thus establishing mitochondrial dysfunctions and ROS overproduction, self-reinforced in a vicious cycle [ 103 , 133 , 154 , 156 , 159 , 187 ].…”

Section: Conclusion and Final Remarksmentioning

confidence: 99%

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Role of Mitochondria in the Oxidative Stress Induced by Electromagnetic Fields: Focus on Reproductive Systems

Santini

Cordone

Falone

et al. 2018

Oxidative Medicine and Cellular Longevity

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Modern technologies relying on wireless communication systems have brought increasing levels of electromagnetic field (EMF) exposure. This increased research interest in the effects of these radiations on human health. There is compelling evidence that EMFs affect cell physiology by altering redox-related processes. Considering the importance of redox milieu in the biological competence of oocyte and sperm, we reviewed the existing literature regarding the effects of EMFs on reproductive systems. Given the role of mitochondria as the main source of reactive oxygen species (ROS), we focused on the hypothesis of a mitochondrial basis of EMF-induced reproductive toxicity. MEDLINE, Web of Science, and Scopus database were examined for peer-reviewed original articles by searching for the following keywords: “extremely low frequency electromagnetic fields (ELF-EMFs),” “radiofrequency (RF),” “microwaves,” “Wi-Fi,” “mobile phone,” “oxidative stress,” “mitochondria,” “fertility,” “sperm,” “testis,” “oocyte,” “ovarian follicle,” and “embryo.” These keywords were combined with other search phrases relevant to the topic. Although we reported contradictory data due to lack of uniformity in the experimental designs, a growing body of evidence suggests that EMF exposure during spermatogenesis induces increased ROS production associated with decreased ROS scavenging activity. Numerous studies revealed the detrimental effects of EMFs from mobile phones, laptops, and other electric devices on sperm quality and provide evidence for extensive electron leakage from the mitochondrial electron transport chain as the main cause of EMF damage. In female reproductive systems, the contribution of oxidative stress to EMF-induced damages and the evidence of mitochondrial origin of ROS overproduction are reported, as well. In conclusion, mitochondria seem to play an important role as source of ROS in both male and female reproductive systems under EMF exposure. Future and more standardized studies are required for a better understanding of molecular mechanisms underlying EMF potential challenge to our reproductive system in order to improve preventive strategies.

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Section: Emf Effects In Male Reproductive System and Fertilitymentioning

confidence: 99%

Section: Conclusion and Final Remarksmentioning

confidence: 99%

Role of Mitochondria in the Oxidative Stress Induced by Electromagnetic Fields: Focus on Reproductive Systems

Santini

Cordone

Falone

et al. 2018

Oxidative Medicine and Cellular Longevity

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“…Cell-phone "trousers" storage has been associated with increased DFI (39,40). This effect -among others-could be mediated by radiation damage to the NAD+ isocitrate dehydrogenase enzyme (41). As for diet, a recent large cross-sectional study in young Danish men (N=2935) found that a prudent diet -as recommended in the present study-was associated with higher median sperm count as compared to a more "western" diet, including high amounts of processed foods, high on fat and sugar (42).…”

Section: Lifestyle and Semen Qualitymentioning

confidence: 69%

The combined effect of lifestyle intervention and antioxidant therapy on sperm DNA fragmentation and seminal oxidative stress in IVF patients: a pilot study

et al. 2022

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Purpose: Sperm DNA fragmentation (SDF) and seminal oxidative stress are emerging measurable factors in male factor infertility, which interventions could potentially reduce. We evaluated (i) the impact of lifestyle changes combined with oral antioxidant intake on sperm DNA fragmentation index (DFI) and static oxidation-reduction potential (sORP), and (ii) the correlation between DFI and sORP. Materials and Methods: We conducted a prospective study involving 93 infertile males with a history of failed IVF/ICSI. Ten healthy male volunteers served as controls. Semen analysis was carried out according to 2010 WHO manual, whereas seminal sORP was measured using the MiOXSYS platform. SDF was assessed by sperm chromatin structure assay. Participants with DFI >15% underwent a three-month lifestyle intervention program, primarily based on diet and exercise, combined with oral antioxidant therapy using multivitamins, coenzyme Q10, omega-3, and oligo-elements. We assessed changes in semen parameters, DFI, and sORP, and compared DFI results to those of volunteers obtained two weeks apart. Spearman rank correlation tests were computed for sORP and DFI results. Results: Thirty-eight (40.8%) patients had DFI >15%, of whom 31 participated in the intervention program. A signifi cant decrease in median DFI from 25.8% to 18.0% was seen after the intervention (P <0.0001). The mean DFI decrease was 7.2% (95% CI: 4.8-9.5%; P <0.0001), whereas it was 0.42% (95%CI; -4.8 to 5.6%) in volunteers (P <0.00001). No differences were observed in sperm parameters and sORP. Based on paired sORP and DFI data from 86 patients, no correlation was observed between sORP and DFI values (rho=0.03). Conclusion: A 3-month lifestyle intervention program combined with antioxidant therapy reduced DFI in infertile men with elevated SDF and a history of failed IVF/ICSI. A personalized lifestyle and antioxidant intervention could improve fertility of subfertile couples through a reduction in DFI, albeit controlled trials evaluating reproductive outcomes are needed before fi rm conclusions can be made. Trial registration number and date: clinicaltrials.gov NCT03898752, April 2, 2019.

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“…A mature (MII) oocyte has a centrally localized distribution of mitochondria, with relatively fewer and larger mitochondrial foci and strong mitochondrial staining around the first polar body [ 32 ]. Many studies have indicated that EMF may disrupt redox homeostasis and the electron transport chain, thus causing mitochondrial dysfunction and ROS overexpression in reproductive cells or organisms [ 34 , 35 , 36 , 37 , 38 ]. In the present study, the number of mitochondria showing the most common type patterns, diffused and polarized types, of matured oocytes in the 25 G group was significantly less than in the control group.…”

Section: Discussionmentioning

confidence: 99%

Effects of electromagnetic waves on oocyte maturation and embryonic development in pigs

Chen

Tsai

Yeh

et al. 2021

Journal of Reproduction and Development

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Our living environment has been full of electromagnetic radiation (EMR) due to the prevailing electronic devices and equipment. Intermediate frequency electromagnetic field (IF-EMF) or waves constitute a significant part of EMR; therefore, an increasing number of household electrical appliances have become a source of IF-EMF, and concerns about IF-EMF on health are gaining more attention. However, little information is available about its impact on female reproductive traits, such as germ cell viability and early embryonic development, particularly at the cellular and molecular levels. In this study, we used porcine oocytes as a model system to explore the effect of IF-EMF at various intensities on the in vitro maturation (IVM) of oocytes and their subsequent embryonic development. Our results showed that no difference in oocyte maturation rates was detected among groups, but the cleavage and blastocyst rates of parthenotes derived from EMF-treated oocytes decreased with the weaker IF-EMF intensity (25 and 50 Gauss) groups compared to the control group (P < 0.05). For cytoplasmic maturation, the weaker IF-EMF intensity groups also showed a peripheral pattern of mitochondrial distribution resembling that of immature oocytes and increased autophagy activity. No obvious differences in cytoskeletal distribution and total cell numbers of blastocysts were investigated in the four IF-EMF treatments compared to those in the control group. Although the underlying mechanism associated with EMF effects on oocytes and embryos is still elusive, we have demonstrated that low intensity IF-EMF exerts harmful effects on porcine oocytes during the maturation stage, carrying over such effects to their subsequent embryonic development.

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Mobile phones electromagnetic radiation and NAD+-dependent isocitrate dehydrogenase as a mitochondrial marker in asthenozoospermia

Cited by 14 publications

References 33 publications

Role of Mitochondria in the Oxidative Stress Induced by Electromagnetic Fields: Focus on Reproductive Systems

Role of Mitochondria in the Oxidative Stress Induced by Electromagnetic Fields: Focus on Reproductive Systems

The combined effect of lifestyle intervention and antioxidant therapy on sperm DNA fragmentation and seminal oxidative stress in IVF patients: a pilot study

Effects of electromagnetic waves on oocyte maturation and embryonic development in pigs

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