Mobile Phones, Non-Ionizing Radiofrequency Fields and Brain Cancer: Is There an Adaptive Response?

Vijayalaxmi, .; Prihoda, Thomas J.

doi:10.2203/dose-response.14-012.vijayalaxmi

Cited by 10 publications

(4 citation statements)

References 27 publications

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“…Vijayalaxmi and Prihoda analysed the INTERPHONE data and found decreased risks in 24.3% of studies and increased risks in only 0.7% of studies for meningioma, and 22.1% vs. 6.6% for glioma28. Furthermore, they proposed that the observed consistent and replicated pattern of reduced risk would be very unlikely to have occurred just by chance and that RF-EMF-induced AR might account for this phenomenon28. However, their conclusion could not explain the increased risks of both tumours.…”

Section: Discussionmentioning

confidence: 99%

Mobile phone signal exposure triggers a hormesis-like effect in Atm+/+ and Atm−/− mouse embryonic fibroblasts

Sun

Wei

Fei

et al. 2016

Sci Rep

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Radiofrequency electromagnetic fields (RF-EMFs) have been classified by the International Agency for Research on Cancer as possible carcinogens to humans; however, this conclusion is based on limited epidemiological findings and lacks solid support from experimental studies. In particular, there are no consistent data regarding the genotoxicity of RF-EMFs. Ataxia telangiectasia mutated (ATM) is recognised as a chief guardian of genomic stability. To address the debate on whether RF-EMFs are genotoxic, we compared the effects of 1,800 MHz RF-EMF exposure on genomic DNA in mouse embryonic fibroblasts (MEFs) with proficient (Atm+/+) or deficient (Atm−/−) ATM. In Atm+/+ MEFs, RF-EMF exposure for 1 h at an average special absorption rate of 4.0 W/kg induced significant DNA single-strand breaks (SSBs) and activated the SSB repair mechanism. This effect reduced the DNA damage to less than that of the background level after 36 hours of exposure. In the Atm−/− MEFs, the same RF-EMF exposure for 12 h induced both SSBs and double-strand breaks and activated the two repair processes, which also reduced the DNA damage to less than the control level after prolonged exposure. The observed phenomenon is similar to the hormesis of a toxic substance at a low dose. To the best of our knowledge, this study is the first to report a hormesis-like effect of an RF-EMF.

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Section: Discussionmentioning

confidence: 99%

Mobile phone signal exposure triggers a hormesis-like effect in Atm+/+ and Atm−/− mouse embryonic fibroblasts

Sun

Wei

Fei

et al. 2016

Sci Rep

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“…The effects of long-term heavy use of mobile phones still need further investigation. Data from parotid gland tumors were provided only from 3 countries, still with not significative results (92). Overall, the weak results provided by the studies on the effects of EMF on brain tumors do not allow to state that EMF are an established cause of cancer, and are therefore not addressed in the recommendations to reduce cancer risk (93).…”

Section: Electromagnetc Radiation Pollutionmentioning

confidence: 99%

Environmental pollutants and brain cancers: where do we stand

Migliaccio¹,

Williams²,

Caracciolo³

2021

Ann Res Oncol

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The global burden of Tumors of the Central Nervous System has increased in the past 25 years. Their prognosis is usually poor, and the less aggressive tumors can lead to severe cognitive and physical disabilities. The etiopathogenesis of CNS tumors is still largely unknown. Genetic factors and ionizing radiation are currently the only well-established risk factors for brain tumors. Several compounds present in the environment have been studied as possible causative agents of CNS tumors, often with inconclusive results. In this review, we focus the attention on certain categories of environmental pollutants for

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“…A more recent prospective study also revealed significantly decreased risk for glioma in mobile phone users [ 26 ]. A potential hypothesis of RF-induced “adaptive response” has been proposed recently for the observed decreased incidence of brain cancer in mobile phone users [ 27 , 28 ]. The detailed IARC evaluations were published in monograph #102 [ 29 ].…”

Section: Evaluationsmentioning

confidence: 99%

“…This is the first time any expert group used the term “protective effect” for the observed risk estimates which were below unity between mobile phone use and cancer. Vijayalaxmi and Prihoda [ 27 ] and Vijayalaxmi et al . [ 28 ] have proposed a hypothesis of RF-induced “adaptive response” to describe such protective effect.…”

Section: Evaluationsmentioning

confidence: 99%

International and National Expert Group Evaluations: Biological/Health Effects of Radiofrequency Fields

Vijayalaxmi

Scarfì²

2014

IJERPH

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The escalated use of various wireless communication devices, which emit non-ionizing radiofrequency (RF) fields, have raised concerns among the general public regarding the potential adverse effects on human health. During the last six decades, researchers have used different parameters to investigate the effects of in vitro and in vivo exposures of animals and humans or their cells to RF fields. Data reported in peer-reviewed scientific publications were contradictory: some indicated effects while others did not. International organizations have considered all of these data as well as the observations reported in human epidemiological investigations to set-up the guidelines or standards (based on the quality of published studies and the “weight of scientific evidence” approach) for RF exposures in occupationally exposed individuals and the general public. Scientists with relevant expertise in various countries have also considered the published data to provide the required scientific information for policy-makers to develop and disseminate authoritative health information to the general public regarding RF exposures. This paper is a compilation of the conclusions, on the biological effects of RF exposures, from various national and international expert groups, based on their analyses. In general, the expert groups suggested a reduction in exposure levels, precautionary approach, and further research.

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Mobile Phones, Non-Ionizing Radiofrequency Fields and Brain Cancer: Is There an Adaptive Response?

Cited by 10 publications

References 27 publications

Mobile phone signal exposure triggers a hormesis-like effect in Atm+/+ and Atm−/− mouse embryonic fibroblasts

Mobile phone signal exposure triggers a hormesis-like effect in Atm+/+ and Atm−/− mouse embryonic fibroblasts

Environmental pollutants and brain cancers: where do we stand

International and National Expert Group Evaluations: Biological/Health Effects of Radiofrequency Fields

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