“…While adsorbed, the large complexes are subjected to lipolysis, whereby cholesterol-rich beta-lipoprotein or chylomicron remnants are formed. Because the cross-linking effect of heparin and calcium at physiological salt concentrations is weaker for beta-lipoprotein than it is for chylomicrons or pre-beta-lipoproteins (32,33), much of the beta-lipoprotein is released into the bloodstream. However, some of the cholesterol-rich degradation products may stay bound to the intimal surface long enough to be incorporated into the arterial intima by pinocytosis, filtration, free diffusion, or some presently undefined mechanisms.…”