European migration studies have been criticised for having certain epistemological and theoretical underpinnings that reproduce hegemonic structures, especially the ‘national order of things’ and colonial legacies. In this article, we propose the concept of ‘entangled mobilities’ to address some of these challenges. Entangled mobilities as a theoretical lens enables us to study specific global and transnational processes, the ways in which they are historically and locally situated, and how they materialise in individual mobilities of differently positioned actors within an unequal political global economy. This lens helps us simultaneously overcome nationality- and ethnicity-centred epistemologies, confront colonial aphasia, and be sensitive to the multiple inequalities and mobility regimes within which human mobilities evolve. Furthermore, the prism of entangled mobilities provides an ideal methodological departure point from which to systematically examine how human mobilities are intertwined and interdependent and to reveal how they are embedded in and shaped by asymmetric, historically evolved power structures. We propose three pragmatic entry points for mobilising the concept: in specific places, in terms of the intersections and interdependencies of different mobile people, and in the context of the biographical trajectories of individuals. Finally, we invite scholars from other fields, such as policy research, to innovatively adapt this approach to gain alternative knowledge and address inequalities.