In China’s labor market, the traditional patterns of “male breadwinners, female housewives” have been changing noticeably, whereas such patterns remain unchanged in the household production field. This phenomenon greatly affects gender equality and social sustainability. Until now, most of the studies have focused on the attribution of micro-factors (e.g., individual income, education level, and time availability) to the formation of this pattern. However, the effect of macro-region factors (e.g., the regional economic development, population composition, employment, and gender norms) on the distribution of housework have been rarely studied. In this study, the data from the China General Social Survey (2015CGSS) and the China Genuine Progress Indicator Survey (2017CGPiS) of Beijing Normal University were comprehensively analyzed. On that basis, a gender norms index was first constructed to measure regional differences in gender concepts. Moreover, this study, by considering macro-region-varying factors, suggested that the synergetic effect between all of the mentioned factors could significantly impact the distribution of housework, especially in eastern China. Nevertheless, in western China, the effect of male gender norms on the distribution of housework is significantly more serious than that of female gender norms, which inspires the authors of this study to strengthen the male’s family consciousness education. All of the mentioned findings could help formulate region-differentiated policies and strategies to achieve more reasonably and sustainably distributed housework in China.