Mobilization of Viable Tumor Cells Into the Circulation During Radiation Therapy

Martin, Olga A.; Anderson, Robin L.; Russell, Prudence A.; Cox, Robert A.; Ivashkevich, Alesia; Swierczak, Agnieszka; Doherty, Judy P.; Jacobs, D.; Smith, Jai; Siva, Shankar; Daly, P.; Ball, David; Martin, Roger F.; MacManus, Michael

doi:10.1016/j.ijrobp.2013.10.033

Cited by 78 publications

(70 citation statements)

References 31 publications

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“…Importantly, a fraction of cells coexpressing epithelial and mesenchymal markers was associated with poorer PFS and OS in MBC [142] . In lung cancer patients it was shown that radiotherapy can induce release of single CTCs or CTC clusters [143] . Comparative analysis of CTC numbers (as single cells or clusters) before and after irradiation showed an increase in CTC number (CK+/CD45-/ DAPI+) in 50% (low radiation group) to 77% (high radiation group) of the patients [143] .…”

Section: Clinical Significance Of Emt In Ctcsmentioning

confidence: 99%

The Landscape of Circulating Tumor Cell Research in the Context of Epithelial-Mesenchymal Transition

Markiewicz

Żaczek²

2017

Pathobiology

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The metastatic spread of cancer accounts for the vast majority of cancer-related deaths. It is mediated by tumor cells circulating in blood (called circulating tumor cells, CTCs), which escaped from their established niches. CTCs give a unique opportunity to look into the metastatic cascade and to study the molecular processes supporting the spread of tumor cells throughout the body. As current therapies are not sufficiently effective in treating metastatic disease, it is important to determine cellular and molecular features of cancer cells that “seed” new tumors in distant organs at early stages. In this review we focus on the role of the epithelial-mesenchymal transition program in providing a survival advantage to metastasizing tumor cells, especially CTCs, and put it in the context of clinical findings.

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Section: Clinical Significance Of Emt In Ctcsmentioning

confidence: 99%

The Landscape of Circulating Tumor Cell Research in the Context of Epithelial-Mesenchymal Transition

Markiewicz

Żaczek²

2017

Pathobiology

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“…Future advances in imaging platforms and the development of new tracers will allow ever more detailed assessments of individual cancers to be made. The integration of more accurate and more personalized imaging with advances in tumor biological characterization, for example by the use of liquid biopsies employing circulating tumor cells (122) or circulating tumor DNA (123) have the potential to further improve the survival of patients with lung cancer treated with RT. …”

Section: Discussionmentioning

confidence: 99%

Anatomic, functional and molecular imaging in lung cancer precision radiation therapy: treatment response assessment and radiation therapy personalization

MacManus

Everitt

Schimek-Jasch

et al. 2017

Transl. Lung Cancer Res.

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This article reviews key imaging modalities for lung cancer patients treated with radiation therapy (RT) and considers their actual or potential contributions to critical decision-making. An international group of researchers with expertise in imaging in lung cancer patients treated with RT considered the relevant literature on modalities, including computed tomography (CT), magnetic resonance imaging (MRI) and positron emission tomography (PET). These perspectives were coordinated to summarize the current status of imaging in lung cancer and flag developments with future implications.Although there are no useful randomized trials of different imaging modalities in lung cancer, multiple prospective studies indicate that management decisions are frequently impacted by the use of complementary imaging modalities, leading both to more appropriate treatments and better outcomes. This is especially true of 18 F-fluoro-deoxyglucose (FDG)-PET/CT which is widely accepted to be the standard imaging modality for staging of lung cancer patients, for selection for potentially curative RT and for treatment planning. PET is also more accurate than CT for predicting survival after RT. PET imaging during RT is also correlated with survival and makes response-adapted therapies possible. PET tracers other than FDG have potential for imaging important biological process in tumors, including hypoxia and proliferation. MRI has superior accuracy in soft tissue imaging and the MRI Linac is a rapidly developing technology with great potential for online monitoring and modification of treatment. The role of imaging in RT-treated lung cancer patients is evolving rapidly and will allow increasing personalization of therapy according to the biology of both the tumor and dose limiting normal tissues.

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“…In our case, the patient did not receive any treatment at the time of SR. Later on, radiotherapy was given for the bone metastasis, which might have further induced regression due to an abscopal effect [19] (A reaction produced following irradiation but occurring outside the zone of actual radiation absorption). A number of preclinical and clinical studies are ongoing to study the proimmunogenic effects of local radiotherapy [20,21].…”

Section: Discussionmentioning

confidence: 99%

Spontaneous Regression of Large Cell Carcinoma of the Lung, a Case Report

Kwint

Heuvel²,

Snijders³

et al. 2015

OMICS J Radiol

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Spontaneous regression of malignancies are a rare biological phenomenon, especially in lung cancer. Here, we present a case of an 80-year old man, with a cT2aN3M1b non-small cell lung cancer of the left upper lobe, whose tumor regressed spontaneously without any treatment. The cause of the spontaneous tumor remission remains unknown in this case. We describe this rare case and review the literature pertaining to spontaneous regression of lung cancer.

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Mobilization of Viable Tumor Cells Into the Circulation During Radiation Therapy

Cited by 78 publications

References 31 publications

The Landscape of Circulating Tumor Cell Research in the Context of Epithelial-Mesenchymal Transition

The Landscape of Circulating Tumor Cell Research in the Context of Epithelial-Mesenchymal Transition

Anatomic, functional and molecular imaging in lung cancer precision radiation therapy: treatment response assessment and radiation therapy personalization

Spontaneous Regression of Large Cell Carcinoma of the Lung, a Case Report

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