Mobilized Peripheral Blood Stem Cells are Pluripotent and Can Be Safely Harvested and Stored for Cartilage Repair

Anz, Adam W.; Torres, J.; Plummer, Hillary A.; Jee, Caroline Siew-Yoke; Dekker, Travis J.; Johnson, Kevin B.; Saw, Khay-Yong

doi:10.1016/j.arthro.2021.04.036

Cited by 6 publications

(2 citation statements)

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“…18 In addition, an in vitro study has found PBSC to be pluripotent. 19 The cases presented here include clinical and radiological results of successful osteochondral regeneration following intra-articular injections of autologous PBSC plus HA after arthroscopic subchondral drilling into OCDs of the knee joint. As shown in a previous study, 15 adjuvant HA injections are beneficial for cartilage repair.…”

Section: Introductionmentioning

confidence: 99%

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Osteochondral Regeneration in the Knee Joint with Autologous Peripheral Blood Stem Cells plus Hyaluronic Acid after Arthroscopic Subchondral Drilling: Report of Five Cases

Saw,

Anz,

Jee

et al. 2023

Orthopaedic Surgery

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BackgroundTreatment of osteochondral defects (OCDs) of the knee joint remains challenging. The purpose of this study was to evaluate the clinical and radiological results of osteochondral regeneration following intra‐articular injections of autologous peripheral blood stem cells (PBSC) plus hyaluronic acid (HA) after arthroscopic subchondral drilling into OCDs of the knee joint.Case PresentationFive patients with OCDs of the knee joint are presented. The etiology includes osteochondritis dissecans, traumatic knee injuries, previously failed cartilage repair procedures involving microfractures and OATS (osteochondral allograft transfer systems). PBSC were harvested 1 week after surgery. Patients received intra‐articular injections at week 1, 2, 3, 4, and 5 after surgery. Then at 6 months after surgery, intra‐articular injections were administered at a weekly interval for 3 consecutive weeks. These 3 weekly injections were repeated at 12, 18 and 24 months after surgery. Each patient received a total of 17 injections. Subjective International Knee Documentation Committee (IKDC) scores and MRI scans were obtained preoperatively and postoperatively at serial visits. At follow‐ups of >5 years, the mean preoperative and postoperative IKDC scores were 47.2 and 80.7 respectively (p = 0.005). IKDC scores for all patients exceeded the minimal clinically important difference values of 8.3, indicating clinical significance. Serial MRI scans charted the repair and regeneration of the OCDs with evidence of bone growth filling‐in the base of the defects, followed by reformation of the subchondral bone plate and regeneration of the overlying articular cartilage.ConclusionThese case studies showed that this treatment is able to repair and regenerate both the osseous and articular cartilage components of knee OCDs.

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Section: Introductionmentioning

confidence: 99%

“…PBSC have also been shown to have the ability to regenerate bone with encouraging clinical results 18 . In addition, an in vitro study has found PBSC to be pluripotent 19 …”

Section: Introductionmentioning

confidence: 99%