Mobius strip in pancreatic cancer: biogenesis, function and clinical significance of circular RNAs

Zhao, Bangbo; Li, Zeru; Cheng, Qi; Li, Tianhao; Wang, Yuanyang; Cao, Hongtao; Yang, Xiaoying; Wang, Weibin

doi:10.1007/s00018-021-03908-5

Cited by 15 publications

(16 citation statements)

References 79 publications

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“…Over the last decade, circRNAs have been reported as important mediators related to the development of chemoresistance in various tumors, such as gastric cancer [ 172 , 173 ], non-small-cell lung cancer [ 174 ], esophageal cancer [ 175 ], pancreatic cancer [ 176 , 177 ], colorectal cancer [ 152 – 154 , 178 ], glioma [ 179 , 180 ], and osteosarcoma [ 181 , 182 ]. However, there are few studies on exosomal circRNA drug resistance to tumors, and the mechanism remains unknown.…”

Section: Main Textmentioning

confidence: 99%

Liquid biopsy at the frontier of detection, prognosis and progression monitoring in colorectal cancer

et al. 2022

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Colorectal cancer (CRC) is one of the most common cancers worldwide and a leading cause of carcinogenic death. To date, surgical resection is regarded as the gold standard by the operator for clinical decisions. Because conventional tissue biopsy is invasive and only a small sample can sometimes be obtained, it is unable to represent the heterogeneity of tumor or dynamically monitor tumor progression. Therefore, there is an urgent need to find a new minimally invasive or noninvasive diagnostic strategy to detect CRC at an early stage and monitor CRC recurrence. Over the past years, a new diagnostic concept called “liquid biopsy” has gained much attention. Liquid biopsy is noninvasive, allowing repeated analysis and real-time monitoring of tumor recurrence, metastasis or therapeutic responses. With the advanced development of new molecular techniques in CRC, circulating tumor cells (CTCs), circulating tumor DNA (ctDNA), exosomes, and tumor-educated platelet (TEP) detection have achieved interesting and inspiring results as the most prominent liquid biopsy markers. In this review, we focused on some clinical applications of CTCs, ctDNA, exosomes and TEPs and discuss promising future applications to solve unmet clinical needs in CRC patients.

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Section: Main Textmentioning

confidence: 99%

Liquid biopsy at the frontier of detection, prognosis and progression monitoring in colorectal cancer

et al. 2022

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“…This unique structure makes circRNAs highly stable and resistant to hydrolysis by RNA exonucleases ( Li H. M. et al, 2019 ), as well as consistently and stably expressed in cells ( Wu et al, 2020 ; Shen et al, 2021 ). CircRNAs sequences are evolutionarily conserved not only in mammals but also in the more evolutionarily distant Drosophila ( Zhao B. et al, 2021 ; Mao X. et al, 2021 ). In addition, the expression of the same circRNA can vary greatly over time or in different tissues, as well as in diseased and non-diseased tissues ( He A. T. et al, 2021 ; Verduci et al, 2021 ).…”

Section: Overview and Biological Properties Of Circular Rnamentioning

confidence: 99%

Emerging Role and Mechanism of circRNAs in Pediatric Malignant Solid Tumors

Shen

Liu

et al. 2022

Front. Genet.

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Circular RNAs (circRNAs) are non-coding RNAs with covalent closed-loop structures and are widely distributed in eukaryotes, conserved and stable as well as tissue-specific. Malignant solid tumors pose a serious health risk to children and are one of the leading causes of pediatric mortality. Studies have shown that circRNAs play an important regulatory role in the development of childhood malignant solid tumors, hence are potential biomarkers and therapeutic targets for tumors. This paper reviews the biological characteristics and functions of circRNAs as well as the research progress related to childhood malignant solid tumors.

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“…The circRNAs are mainly formed by processing protein-coding genes by RNA polymerase II( Ashwal-Fluss et al, 2014 ; Li et al, 2019 ; Ali et al, 2021 ; Sinha et al, 2021 ). Meanwhile circRNAs biosynthesis is mediated by RNA binding proteins, intron pair driven and lasso driven, and thus has an important role in regulating adjacent splice sites and promoting circular biosynthesis ( Wu et al, 2021a ; van Zonneveld et al, 2021 ; Zhao et al, 2021 ). Currently circRNAs have also been shown to have many characteristics.…”

Section: Biogenesis and Classification Of Circular Rnasmentioning

confidence: 99%

“…Studies have shown that circRNAs are abundant and stable in exosomes, and some circRNAs are more highly expressed in blood than in tissues ( D'Ambrosi et al, 2021 ; Reese and Dhayat, 2021 ; Tian et al, 2021 ; van Zonneveld et al, 2021 ). The high expression and stability of circRNAs in body fluids would be more beneficial for their clinical applications ( Bu et al, 2021 ; Fontemaggi et al, 2021 ; Wang et al, 2021h ; Zhao et al, 2021 ). However, despite the identification of thousands of tissue- and disease-specific circRNAs by RNA-seq ( Kaushik et al, 2021 ; Tian-Zhao et al, 2021 ), the understanding of the mechanism of circRNAs generation and biological functions is limited at this stage.…”

Section: Conclusion and Future Prospectsmentioning

confidence: 99%

Research Progress of circRNAs in Glioblastoma

Guo

Piao

2021

Front. Cell Dev. Biol.

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Circular RNAs (circRNAs) are a class of single-stranded covalently closed non-coding RNAs without a 5′ cap structure or 3′ terminal poly (A) tail, which are expressed in a variety of tissues and cells with conserved, stable and specific characteristics. Glioblastoma (GBM) is the most aggressive and lethal tumor in the central nervous system, characterized by high recurrence and mortality rates. The specific expression of circRNAs in GBM has demonstrated their potential to become new biomarkers for the development of GBM. The specific expression of circRNAs in GBM has shown their potential as new biomarkers for GBM cell proliferation, apoptosis, migration and invasion, which provides new ideas for GBM treatment. In this paper, we will review the biological properties and functions of circRNAs and their biological roles and clinical applications in GBM.

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Mobius strip in pancreatic cancer: biogenesis, function and clinical significance of circular RNAs

Cited by 15 publications

References 79 publications

Liquid biopsy at the frontier of detection, prognosis and progression monitoring in colorectal cancer

Liquid biopsy at the frontier of detection, prognosis and progression monitoring in colorectal cancer

Emerging Role and Mechanism of circRNAs in Pediatric Malignant Solid Tumors

Research Progress of circRNAs in Glioblastoma

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