Modafinil for cognitive neuroenhancement in healthy non-sleep-deprived subjects: A systematic review

Battleday, Ruairidh M.; Brem, Anna-Katharine

doi:10.1016/j.euroneuro.2015.12.023

Cited by 51 publications

(84 citation statements)

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“…The most promising ones include methylphenidate [43], already used for the treatment of attention deficit hyperactivity disorder [44], and modafinil. The latter is used off-label by many healthy people to reduce mental fatigue and sleepiness [45], and enhance cognition [46]. In one study, modafinil was shown to reduce perception of effort and improve performance during vigorous exercise [47], and it seems to have a good safety profile [46].…”

Section: Caffeine and Other Psychoactive Drugsmentioning

confidence: 99%

“…The latter is used off-label by many healthy people to reduce mental fatigue and sleepiness [45], and enhance cognition [46]. In one study, modafinil was shown to reduce perception of effort and improve performance during vigorous exercise [47], and it seems to have a good safety profile [46]. However, further studies on the side effects of prolonged modafinil use in healthy humans are necessary.…”

Section: Caffeine and Other Psychoactive Drugsmentioning

confidence: 99%

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Can Doping be a Good Thing? Using Psychoactive Drugs to Facilitate Physical Activity Behaviour

Marcora

2015

Sports Med

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Section: Caffeine and Other Psychoactive Drugsmentioning

confidence: 99%

Section: Caffeine and Other Psychoactive Drugsmentioning

confidence: 99%

Can Doping be a Good Thing? Using Psychoactive Drugs to Facilitate Physical Activity Behaviour

Marcora

2015

Sports Med

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“…Modafinil is a central nerve stimulant (CNS) eugeroic that directly increases cortical catecholamine levels, indirectly upregulates cerebral serotonin, glutamate, orexin, and histamine levels, and indirectly decreases cerebral gamma-aminobutyric acid levels [1]. It is prescribed as a wakefulness enhancer; in narcoleptic patients it is an effective treatment of excessive daytime tiredness [2].…”

Section: Introductionmentioning

confidence: 99%

“…In healthy non-sleep deprived individuals modafinil can enhance attention, executive functions, and learning; and there is a low level of side effects or mood changes [1]. Modafinil can enhance task enjoyment and performance on cognitive tests of planning and working memory in healthy non-sleep deprived individuals [6].…”

Section: Introductionmentioning

confidence: 99%

The Effects of Modafinil in People with a Diagnosis of Schizophrenia

Griffiths¹,

Girardi²

2018

OJPsych

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This review seeks to describe the use and effects of the drug modafinil. Specifically, it presents the research of the impact of modafinil for people with diagnosis and experience of schizophrenia. Recent reviews have shown that modafinil can positively impact on cognitive function in people with a diagnosis of schizophrenia. There is emerging evidence for the positive impact of modafinil on negative symptoms, functioning, quality of life, wellbeing, and body mass index (BMI) for people with schizophrenia. Compared to other central nerve stimulant (CNS) drugs, modafinil has a low risk of dependency and few negative side effects; but there are risks of triggering positive symptoms in schizophrenia. A well designed and sufficiently large randomised control trial is required to test the potential of the impact of modafinil in the lives of people with a diagnosis of schizophrenia. Future research should report participant's perspective of the value of modafinil connected to what concerns them and what they want to achieve in their lives.

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“…ADHD) disability. A recent review points to difficulties in evaluating efficacy (Battleday and Brem 2015):…”

Section: Impasse In the Debatementioning

confidence: 99%

Introduction: Critiquing technologies of the mind: enhancement, alteration, and anthropotechnology

Meacham

2017

Phenom Cogn Sci

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Modafinil for cognitive neuroenhancement in healthy non-sleep-deprived subjects: A systematic review

Cited by 51 publications

References 0 publications

Can Doping be a Good Thing? Using Psychoactive Drugs to Facilitate Physical Activity Behaviour

Can Doping be a Good Thing? Using Psychoactive Drugs to Facilitate Physical Activity Behaviour

The Effects of Modafinil in People with a Diagnosis of Schizophrenia

Introduction: Critiquing technologies of the mind: enhancement, alteration, and anthropotechnology

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