Modafinil in treatment of fatigue in multiple sclerosis

Zifko, Udo; Rupp, Monika; Schwarz, Sigrid C.; Zipko, Harald; Maida, E.

doi:10.1007/s00415-002-0765-6

Cited by 171 publications

(101 citation statements)

References 35 publications

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“…Fatigue was also associated with reduced sexual desires in MS patients (Zifko, 2003). Other studies have shown how yoga training was used to reduce fatigue and improve MS patients' sleep quality (Sookcharoen, 2001;Wood, 1993), and because sleep is one of the most important fatigue related factors among the MS patients, it seems prudent to consider yoga for its multidimensional benefits.…”

Section: Discussionmentioning

confidence: 98%

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Yoga Effects on Physical Activity and Sexual Satisfaction among Iranian Women with Multiple Sclerosis: A Randomized Controlled Trial

Najafidoulatabad¹,

Mohebbi²,

Nooryan³

2014

Afr. J. Trad. Compl. Alt. Med.

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Background: Multiple Sclerosis (MS) is a chronic and disabling disease resulting in disabilities in young and middle-aged persons. In this study, researchers explored the effect of yoga techniques on physical activities and sexual function among some Iranian women with MS. Materials and Methods: In this study, 60 Iranian women with multiple sclerosis (MS) were placed in two equally divided control and case groups through random selection to assess pre-and post-effects of yoga exercises on their physical activities and sexual satisfaction levels. Women in case group were offered a series of yoga training and exercises for 3 months, which consisted of 8 sessions per month for 60 to 90 minutes at each session. Yoga training program included the 3 principles of slow motions (Hatayoga), respiratory exercises (Pranayama) and centralization to control mind via meditation, expansion and stasis (Rajayoga). After 3 months both groups were surveyed using the initial questionnaire to evaluate and compare findings with the base-line data. Results: Researchers found significant statistical difference in physical activity and sexual satisfaction levels among the women in case group (P=0.001). Women in case group showed improvement in physical ability while women in control group manifested exacerbated symptoms.

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Section: Discussionmentioning

confidence: 98%

“…In a study by Zifko (2003) in the United States, 70-90% of MS patients reported symptoms of pain and fatigue, 50-60% perceived fatigue which prohibited the scope of their activities of daily living. Fatigue was also associated with reduced sexual desires in MS patients (Zifko, 2003).…”

Section: Discussionmentioning

confidence: 99%

Yoga Effects on Physical Activity and Sexual Satisfaction among Iranian Women with Multiple Sclerosis: A Randomized Controlled Trial

Najafidoulatabad¹,

Mohebbi²,

Nooryan³

2014

Afr. J. Trad. Compl. Alt. Med.

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“…14 Several small studies have found that treatment with modafinil, a wake-promoting agent, improved symptoms of MS fatigue, although in a larger randomized controlled trial there was no difference. [15][16][17] These studies did not use objective measures of alertness. Beyond these pharmaceutical studies, little research has been conducted into whether poor sleep and decreased alertness are major determinants of MS fatigue.…”

Section: Original Articlementioning

confidence: 99%

Multiple Sclerosis Fatigue is Associated with Reduced Psychomotor Vigilance

Rotstein

O’Connor²,

Lee³

et al. 2012

Can. J. Neurol. Sci.

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Fatigue is a common and disabling symptom in those who suffer from multiple sclerosis (MS). Studies indicate that more than 75% of MS patients suffer from fatigue. 1-3 Two-thirds of MS patients rank fatigue as one of their three most debilitating symptoms. 1 Multiple sclerosis fatigue is particularly aggravated by heat and can significantly impair physical activity. 1 It is one of the main causes of work absenteeism in individuals with MS. 4 Yet fatigue is a lay term that remains subjectively defined and assessment of fatigue is therefore dependent on self-report. Perhaps as a result, the physiologic substrates of MS fatigue are not well-described. The subjective experience of fatigue is multifactorial and has been correlated with factors such as disability, depression, and pain. [5][6][7] Interestingly, no clear association has been established between MS fatigue and demographic factors, such as age and gender; lesion burden; or the clinical form of MS. 1,[7][8][9] ABSTRACT: Background: Fatigue is common and disabling in multiple sclerosis, yet its physiologic substrates remain poorly defined. The aim of this study was to determine the relationship between fatigue and an objective measure of alertness in MS patients. Methods: This study enrolled 49 consecutive MS clinic patients at two academic hospitals in Toronto. Alertness was assessed with the psychomotor vigilance test (PVT), a ten-minute reaction-time test that measures attention and is sensitive to sleep loss. Patients with visual impairment or arm weakness were excluded. Validated tools were used to assess fatigue, disability, mood, and pain. Results: The average age was 43; 65% were women. Median EDSS was 2.0 (range 0-7.5). Fifty-five percent reported a high impact of fatigue on their lives. Psychomotor vigilance test performance was worse than in an age-and sex-matched population, with a mean reaction time of 315 msecs and 3.98 lapses >500 msec (p<0.001). In a multiple regression analysis, fatigue was the most significantly correlated factor with mean PVT reaction time (p<0.05), and disability was also significantly correlated (p<0.01). Mood and pain did not correlate with the PVT. Eighteen (37%) reported often experiencing restlessness in their legs at night. Conclusion: Subjective fatigue and disability were associated with poor performance on alertness testing in MS patients. This research highlights a potential role for psychomotor vigilance testing in providing a standardized assessment tool for an important aspect of MS-related fatigue.RÉSUMÉ: La fatigue dans la sclérose en plaques est associée à une diminution de la vigilance psychomotrice. Contexte : La fatigue est un symptôme fréquent et invalidant chez les patients atteints de la sclérose en plaques (SP) et sa cause physiologique demeure mal définie. Le but de cette étude était de déterminer la relation entre la fatigue et une mesure objective de vigilance chez des patients atteints de la SP. Méthode : Nous avons inclus 49 patients consécutifs de cliniques de SP situées dans deux hôpitaux ac...

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“…Fatigue or weakness can also make navigating long distances difficult for a wheelchair user. Diagnoses that can produce muscle fatigue or weakness include MS (43%-90% of cases) [4,36], severe TBI (37%-50%) [54,57], and ALS (26%) [16].…”

Section: Upper-body Physical Impairmentmentioning

confidence: 99%

“…Of people with MS, 85 percent reported gait and motor disturbances as their primary complaint [32]. Symptoms that are relevant to wheelchair use include spasticity, tremors, fatigue, ataxia, and impaired executive reasoning [4,25,[33][34][35][36].…”

Section: Multiple Sclerosismentioning

confidence: 99%

How many people would benefit from a smart wheelchair?

Simpson

LoPresti²,

Cooper³

2008

JRRD

205

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Abstract-Independent mobility is important, but some wheelchair users find operating existing manual or powered wheelchairs difficult or impossible. Challenges to safe, independent wheelchair use can result from various overlapping physical, perceptual, or cognitive symptoms of diagnoses such as spinal cord injury, cerebrovascular accident, multiple sclerosis, amyotrophic lateral sclerosis, and cerebral palsy. Persons with different symptom combinations can benefit from different types of assistance from a smart wheelchair and different wheelchair form factors. The sizes of these user populations have been estimated based on published estimates of the number of individuals with each of several diseases who (1) also need a wheeled mobility device and (2) have specific symptoms that could interfere with mobility device use.

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Modafinil in treatment of fatigue in multiple sclerosis

Abstract: Treatment with modafinil significantly improves fatigue and sleepiness and is well tolerated by patients with MS. Unlike the higher dose regimen required in narcolepsy, a low-dose regimen of modafinil is effective in MS.

Cited by 171 publications

References 35 publications

Yoga Effects on Physical Activity and Sexual Satisfaction among Iranian Women with Multiple Sclerosis: A Randomized Controlled Trial

Yoga Effects on Physical Activity and Sexual Satisfaction among Iranian Women with Multiple Sclerosis: A Randomized Controlled Trial

Multiple Sclerosis Fatigue is Associated with Reduced Psychomotor Vigilance

How many people would benefit from a smart wheelchair?

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