The interaction of guided waves with a material discontinuity is not well understood. This study investigates the propagation behavior of the fundamental Lamb-wave modes, the symmetric mode ( S0) and the anti-symmetric mode ( A0), upon interaction with welded joints of dissimilar materials. A plate with an intact AA6061-T6/AZ31B dissimilar joint was employed, and the interaction of the propagating wave with the material interface was scrutinized numerically and validated experimentally. Plane-wave approximation was also adopted to investigate the behavior of the symmetric modes, and its performance was compared to the numerical and experimental results. The effect of the angle of incidence on the reflection, transmission, and mode conversion of the incident modes was analyzed. The study was conducted as the excited Lamb wave propagated from AA6061-T6 to AZ31B (forward), and when the propagation direction was reversed (backward). Different techniques were developed to identify the in-plane and out-of-plane modes from the three-dimensional measurements and to separate wave reflections and transmissions of the joint. The fundamental shear-horizontal guided-wave mode ( SH0 mode) has evolved upon the interaction of the obliquely-incident Lamb-wave S0 mode with the interface. While the reflection of the SH0 mode from the joint was found to be well-pronounced, its transmission to the other material is extremely weak. The analytical solution, using plane-wave approximation, was accurate for predicting the behavior of the in-plane modes ( S0 and S0– SH0 modes). Despite the peaks appearing at the critical angle, the absolute values of the reflection coefficients of the studied modes have shown similar trends between the forward and the backward propagation directions. The total reflection of the excited wave, from the material interface, was not observed in any condition. The transmission coefficients of the S0 and A0 modes are almost constant until reaching very steep incidence angles [Formula: see text]. The results were experimentally validated on an intact AA6061-T6/AZ31B friction-stir-welded joint using an excitation frequency of 200 kHz. Measurements along the transmission and reflection directions were conducted using a three-dimensional scanning laser vibrometer. Experimental results showed very good agreement with both the analytical and the numerical ones.