Mode of action of new diethylamines in lycopene cyclase inhibition and in photosystem II turnover

Fedtke, Carl; Depka, Brigitte; Schallner, Otto; Tietjen, Klaus; Trebst, Achim; Wollweber, Detlef; Wroblowsky, Heinz‐Jürgen

doi:10.1002/ps.296

Cited by 18 publications

(11 citation statements)

References 11 publications

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“…Nevertheless β‐carotene is essential as PS II and the D1 protein cannot assemble without its presence 36, 37. We have discussed this in relation to the mode of action of herbicides that inhibit the lycopene cyclase 38. Newly synthesized carotene is required in that assembly 37.…”

Section: Discussionmentioning

confidence: 99%

Reversal of the inhibition of photosynthesis by herbicides affecting hydroxyphenylpyruvate dioxygenase by plastoquinone and tocopheryl derivatives inChlamydomonas reinhardtii

Trebst

Depka

Jäger

et al. 2004

Pest Management Science

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Isoxaflutole or pyrazolate inhibition of tocopherol and plastoquinone biosynthesis in the green alga Chlamydomonas reinhardtii Dang leads to the inactivation of photosystem II and the degradation of its reaction centre D1 protein when exposed to strong light. Cell-permeable short-chain derivatives of plastoquinone and tocopherol were tested in the reversal. Addition of decyl-plastoquinone reverses herbicide-induced inhibition of photosynthesis and inactivation of photosystem II in short-time (1 h) exposure of the algae to high light. In high light longer than 1 h, decyl-plastoquinone alone loses effectiveness, but a synthetic permeable tocopheryl derivative retards the inhibitory effects on photosystem II and on the degradation of the D1 protein. This indicates that tocopherol deficiency induced by the herbicides makes a major contribution to their secondary mode of action in high light stress.

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Section: Discussionmentioning

confidence: 99%

Reversal of the inhibition of photosynthesis by herbicides affecting hydroxyphenylpyruvate dioxygenase by plastoquinone and tocopheryl derivatives inChlamydomonas reinhardtii

Trebst

Depka

Jäger

et al. 2004

Pest Management Science

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“…Greenhouse studies were conducted in October 2003 at the Stine-Haskell Research Center in Newark, DE to evaluate POST applications of several CBI alone and in mixtures with the PSII inhibitor atrazine. The CBI chosen and their sites of action are as follows: (1) CPTA-LC inhibitor (Fedtke et al 2001); (2) fosmidomycin-DOXP reductoisomerase inhibitor (Kuzuyama et al 1998); (3) DFPC-ZDS inhibitor (Chan et al 2004); (4) mesotrione-HPPD inhibitor; (5) norflurazon-PDS inhibitor; and (5) clomazone (the active metabolite ketoclomazone is actually the active herbicide at this site of action)-DOXP synthase (Mallory- Smith and Retzinger 2003;Mueller et al 2000; Figure 1). Seeds of common cocklebur, red morningglory, and giant foxtail, were planted into individual 6.35-cm by 6.35-cm pots containing high organic matter potting media.…”

Section: Methodsmentioning

confidence: 99%

Differential Response of Several Carotenoid Biosynthesis Inhibitors in Mixtures with Atrazine

et al. 2007

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Greenhouse studies were conducted in 2003 at the Stine–Haskell Research Center to determine whether herbicide inhibitors of six specific sites in the carotenoid biosynthesis pathway would elicit synergistic responses when applied postemergence (POST) in combination with the photosystem II (PSII) inhibitor atrazine. Based on data analysis with the Isobole method, synergistic responses were observed on red morningglory, common cocklebur, and giant foxtail when atrazine was applied in mixtures with the deoxy-D-xylulose-5-phosphate reductoisomerase (DOXP reductoisomerase) inhibitor fosmidomycin, thep-hydroxyphenylpyruvate dioxygenase (HPPD) inhibitor mesotrione, and the DuPont proprietary zeta-carotene desaturase (ZDS) inhibitor DFPC. Clomazone (its metabolite ketoclomazone is the actual enzyme inhibitor), an inhibitor of 1-deoxy-D-xylulose-5-phosphate synthatase (DOXP synthase), provided synergistic responses on red morningglory, but antagonistic responses on both common cocklebur and giant foxtail when applied in mixtures with atrazine. Combinations of the lycopene cyclase (LC) inhibitor, CPTA, with atrazine produced synergistic responses on both common cocklebur and giant foxtail but were antagonistic on red morningglory. Norflurazon, a phytoene desaturase (PDS) inhibitor, applied in mixtures with atrazine provided synergistic responses on red morningglory, antagonistic responses on giant foxtail, and independent responses on common cocklebur. Because carotenoids have been determined to play a key role in quenching singlet oxygen species in the chloroplast and also assist in the maintenance of the D1 protein in PSII, this might help explain the synergistic responses with atrazine observed in our studies.

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“…In order to define the molecular form of lycopene accumulated in AM‐treated etioplasts, the peak of this pigment was identified by HPLC (carried out according to Pancaldi et al 1998) using authentic ( trans ) lycopene (Sigma Aldrich Chemie, 82024 Taufkirchen, Germany) as standard. The lycopene form was recognized by recording its absorption spectrum with a diode array detector (module 168 Beckman Gold, New York, USA), and by comparing it with the standard (Fedtke et al 2001).…”

Section: Methodsmentioning

confidence: 99%

Impaired carotenogenesis can affect organization and functionality of etioplast membranes

Moro

Vecchia

Rocca

et al. 2004

Physiologia Plantarum

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The effects of impaired carotenogenesis on plastid membrane organization, functionality and stability were studied in etiolated barley plants grown at 20 and 30degreesC. The plants were treated with norflurazon or amitrole, two herbicides affecting phytoene desaturation and lycopene cyclization, respectively. At 20degreesC, the amitrole-treated etioplasts, which accumulated lycopene in their inner membranes, exhibited disorganized prolamellar bodies, containing a prevalent form of non-phototransformable protochlorophyllide (Pchlide). They also showed a certain difficulty in reducing the phototransformable pigment to chlorophyllide when exposed to light, and were unable to reform the active ternary complex [protochlorophyllide-oxidoreductase (POR)-Pchlide-NADPH] when placed back in darkness. No ultrastructural alterations were found in norflurazon-treated etioplasts, with carotenogenesis inhibited at the phytoene desaturation step. In these latter organelles, Pchlide, whose forms were comparable with those of the control etioplasts, was photoreduced quickly after illumination and the ternary complex was reformed during a subsequent dark period. Thus, the impaired carotenogenesis leading to the accumulation of lycopene showed greater interference with the etioplast membrane arrangement and functionality than did the earlier interruption of the biosynthetic pathway at the phytoene level. This might be due to the different interactions of the distinct carotenoid precursors with other membrane components. However, in etioplasts of norflurazon-treated plants, a rise in growth temperature caused a partial demolition of prolamellar bodies, showing a lowered thermostability of the carotenoid-deficient membranes. This latter effect strengthens the concept that a correct and complete carotenogenesis pathway, leading to the synthesis of polar carotenoids (i.e. xanthophylls), is required for the maintenance of stable plastid membranes

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Mode of action of new diethylamines in lycopene cyclase inhibition and in photosystem II turnover

Cited by 18 publications

References 11 publications

Reversal of the inhibition of photosynthesis by herbicides affecting hydroxyphenylpyruvate dioxygenase by plastoquinone and tocopheryl derivatives inChlamydomonas reinhardtii

Reversal of the inhibition of photosynthesis by herbicides affecting hydroxyphenylpyruvate dioxygenase by plastoquinone and tocopheryl derivatives inChlamydomonas reinhardtii

Differential Response of Several Carotenoid Biosynthesis Inhibitors in Mixtures with Atrazine

Impaired carotenogenesis can affect organization and functionality of etioplast membranes

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