Mode of Action of Prolactin on Normal and Neoplastic Mammary Tissues

Rillema, James A.

doi:10.1007/978-94-011-8045-0_4

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1984

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“…However, in subsequent studies with other prolactin preparations, including NIH-PS-14, no effects were observed (Rillema 1982). We are, therefore, not presently convinced that prolactin directly activates phospholipase A 2 in mammary tissues.…”

Section: Discussionmentioning

confidence: 80%

Prolactin-like Actions of Phospholipase C on RNA and Casein Synthesis in Mouse Mammary Gland Explants

Rillema¹

1984

Horm Metab Res

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Phospholipase C stimulated the rate of [3H]-uridine incorporation into RNA in cultured mouse mammary gland explants. This effect was similar to that elicited by prolactin in that the time-course and magnitude of response were the same. In addition, the effects of prolactin and phospholipase C were non-additive when these agents were tested together. Although phospholipase C, by itself, had no effect on the rate of [3H]-leucine incorporation into casein, it was found to stimulate casein synthesis when the explants were simultaneously exposed to 0.5 mM spermidine. These observations are compatible with the idea that at least certain of the actions of prolactin in the mammary gland may be carried out via phospholipase C.

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Section: Discussionmentioning

confidence: 80%

Prolactin-like Actions of Phospholipase C on RNA and Casein Synthesis in Mouse Mammary Gland Explants

Rillema¹

1984

Horm Metab Res

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show abstract

Mode of Action of Prolactin on Normal and Neoplastic Mammary Tissues

Cited by 1 publication

References 54 publications

Prolactin-like Actions of Phospholipase C on RNA and Casein Synthesis in Mouse Mammary Gland Explants

Prolactin-like Actions of Phospholipase C on RNA and Casein Synthesis in Mouse Mammary Gland Explants

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