Mode of Antihypertensive Action of Nitrendipine

Garthoff, Bernward; Luckhaus, G

doi:10.1097/00005344-198400067-00006

Cited by 19 publications

(5 citation statements)

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“…27 In addition, the calcium channel blocking agent nitrendipine has also been found to prevent stroke in SHRSP without affecting blood pressure. 28 Thus, although TXA 2 may contribute to the blood pressure rise in SHRSP, other factors appear to be involved in the evolution of severe hypertension and stroke.…”

Section: Figure 1 Serum Thromboxane B 2 (Txb 2 ) Concentrations In Imentioning

confidence: 99%

Thromboxane A2 in severe hypertension and stroke in stroke-prone spontaneously hypertensive rats.

Stier

Benter

Levine

1988

Stroke

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A 2 is a prostanoid having potent platelet aggregatory and vasoconstrictor properties. To determine a possible role for thromboxane A 2 in the development of severe hypertension and stroke, we chronically administered the selective thromboxane A 2 synthase inhibitor UK-38,485 (Dazmegrel) to stroke-prone spontaneously hypertensive rats (SHRSP). Serum thromboxane B 2 (the stable hydrolysis product of thromboxane A 2 ) generation was significantly greater in incubates of whole blood from SHRSP than in those from normotensive control Wistar-Kyoto rats and was inhibited >89% by UK-38,485 administered in vivo. In 10 male SHRSP fed a Japanese-style rat chow and given 1% NaCl in drinking water to accelerate the occurrence of stroke, treatment with 100 mg/kg/day UK-38,485 by gavage starting at 8.

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Section: Figure 1 Serum Thromboxane B 2 (Txb 2 ) Concentrations In Imentioning

confidence: 99%

Thromboxane A2 in severe hypertension and stroke in stroke-prone spontaneously hypertensive rats.

Stier

Benter

Levine

1988

Stroke

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“…The present paper was undertaken to determine whether oxodipine was able to delay irreversible injury and to reduce the size of the myocardial infarct induced by subcutaneous injection of isoproterenol in the rat. Moreover, the possible cardioprotective effect of oxodipine was compared with that exhibited by nitrendipine, another dihydropyridine derivative with potent antihypertensive effect and coronary vasodilator properties (Kazda et d. I984), which exhibits protective effects in different animal models of myocardial ischaemia (Kazda et al 1984;Waltier & Gross 1984;Knorr et ul. 1987;Waltier et ul.…”

mentioning

confidence: 99%

Effects of Oxodipine and Nitrendipine on the Size of Experimental Myocardial Infarct in the Rat

Perez-Cao

Gil-Loyzaga

Merchán-Pérez

et al. 1994

Pharmacology & Toxicology

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The protective effect of either oxodipine or nitrendipine (4 mg/kg/twice daily, orally), two dihydropyridines exhibiting calcium channel-blocking properties, against induced infarct-like lesions was examined. Experimental myocardial infarct-like lesions were induced in rats by subcutaneous injection of isoproterenol (0.5 mg/kg). The lesions were mainly located in subendocardial areas of the free wall of the left ventricle, and were intramural at the apex and ventricular septum. Pretreatment with oxodipine significantly reduced the infarct size in the apical and basal myocardium (P < 0.05). Possible explanations for the lack of effect of nitrendipine pretreatment are discussed.

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“…Nitrendipine is a second-generation calcium antagonist with a high vascular selectivity and is not associated with stimulation of the sympathetic nervous system and the renin-angiotensin system or with accumulation of sodium and water [19], besides its potent dilatation of the resistance vessels. Experimental findings have shown that the development of vascular lesions associated with hypertension is not merely dependent on the high intravascular pressure, but some additional factors must be involved in the prophylactic effect of nitrendipine [20]. Besides the fact that lisinopril does not influence the pulsatility index of the tibial artery, it was shown earlier that converting enzyme inhibitors increase the arterial compliance in the systemic and the forearm circulations [1].…”

Section: Discussionmentioning

confidence: 99%

Comparison of lisinopril and nitrendipine on the pulsatility index in mild essential arterial hypertension

Duprez

Buyzere

Brusselmans

et al. 1992

Cardiovasc Drug Ther

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A double-blind, randomized crossover study was performed in 21 patients with essential arterial hypertension. Nitrendipine 20 mg o.d. and lisinopril 20 mg o.d. were given in a randomized order during a period of each 8 weeks. Nitrendipine and lisinopril decreased systolic and mean arterial blood pressure to a similar level without a significant increase in heart rate. The mean diastolic blood pressure was smaller with the lisinopril treatment than with the nitrendipine treatment. The blood pressure decrease was maintained in the sitting and standing position. Furthermore, only nitrendipine decreased the pulsatility index at the tibial posterior arteries, while lisinopril did not influence it significantly. This finding means that mechanisms other than the blood-pressure lowering effect are involved in the decrease of the pulsatility index.

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Mode of Antihypertensive Action of Nitrendipine

Cited by 19 publications

References 0 publications

Thromboxane A2 in severe hypertension and stroke in stroke-prone spontaneously hypertensive rats.

Thromboxane A2 in severe hypertension and stroke in stroke-prone spontaneously hypertensive rats.

Effects of Oxodipine and Nitrendipine on the Size of Experimental Myocardial Infarct in the Rat

Comparison of lisinopril and nitrendipine on the pulsatility index in mild essential arterial hypertension

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