Mode of delivery affects the bacterial community in the newborn gut

Biasucci, Giacomo; Rubini, Monica; Riboni, Sara; Morelli, Lorenzo; Bessi, Elena; Retetangos, Cristiana

doi:10.1016/j.earlhumdev.2010.01.004

Cited by 426 publications

(335 citation statements)

References 31 publications

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“…For example, infants born by vaginal delivery are colonized by the maternal microbiome (eg, fecal and vaginal bacteria), whereas infants born by cesarean delivery are exposed to different commensals from the skin and hospital environment. [10][11][12] Infant diet also impacts the microbiome such that the diet of the breast fed infant differs from those fed with infant formula. 13 The gut microbiome contributes to the early programming of epithelial barrier function, angiogenesis, and innate and host immune function.…”

Section: Development Of the Gastrointestinal M Icrobiomementioning

confidence: 99%

Visceral Pain and Gastrointestinal Microbiome

Chichlowski

Rudolph

2015

J Neurogastroenterol Motil

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A complex set of interactions between the microbiome, gut and brain modulate responses to visceral pain. These interactions occur at the level of the gastrointestinal mucosa, and via local neural, endocrine or immune activity; as well as by the production of factors transported through the circulatory system, like bacterial metabolites or hormones. Various psychological, infectious and other stressors can disrupt this harmonious relationship and alter both the microbiome and visceral pain responses. There are critical sensitive periods that can impact visceral pain responses in adulthood. In this review we provide a brief background of the intestinal microbiome and emerging concepts of the bidirectional interactions between the microbiome, gut and brain. We also discuss recent work in animal models, and human clinical trials using prebiotics and probiotics that alter the microbiome with resultant alterations in visceral pain responses.

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Section: Development Of the Gastrointestinal M Icrobiomementioning

confidence: 99%

Visceral Pain and Gastrointestinal Microbiome

Chichlowski

Rudolph

2015

J Neurogastroenterol Motil

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“…5 Early environmental exposures as delivery mode (vaginal delivery versus delivery by caesarean section (CS)) and administration of antibiotics in infancy have previously been found to affect the establishment and diversity of the infants' intestinal microbiota. [6][7][8][9][10][11][12][13][14] Vaginally delivered children are colonised with bacterial strains from the mothers' vaginal-and gastrointestinal tract during delivery in contrast to children delivered by CS, and these differences seem to persist throughout infancy. 10 Furthermore, exposure to (especially broad spectrum) antibiotics in infancy may have long-term implications on the gut microbial composition.…”

Section: Introductionmentioning

confidence: 99%

Childhood overweight after establishment of the gut microbiota: the role of delivery mode, pre-pregnancy weight and early administration of antibiotics

et al. 2011

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Objective: To investigate whether delivery mode (vaginal versus by caesarean section), maternal pre-pregnancy body mass index (BMI) and early exposure to antibiotics (o6 months of age) influence child's risk of overweight at age 7 years, hence supporting the hypotheses that environmental factors influencing the establishment and diversity of the gut microbiota are associated with later risk of overweight. Design: Longitudinal, prospective study with measure of exposures in infancy and follow-up at age 7 years. Methods: A total of 28 354 mother-child dyads from the Danish National Birth Cohort, with information on maternal prepregnancy BMI, delivery mode and antibiotic administration in infancy, were assessed. Logistic regression analyses were performed with childhood height and weight at the 7-year follow-up as outcome measures. Results: Delivery mode was not significantly associated with childhood overweight (odds ratio (OR):1.18, 95% confidence interval (CI): 0.95-1.47). Antibiotics during the first 6 months of life led to increased risk of overweight among children of normal weight mothers (OR: 1.54, 95% CI: 1.09-2.17) and a decreased risk of overweight among children of overweight mothers (OR: 0.54, 95% CI: 0.30-0.98). The same tendency was observed among children of obese mothers (OR: 0.85, 95% CI: 0.41-1.76). Conclusion: The present cohort study revealed that a combination of early exposures, including delivery mode, maternal pre-pregnancy BMI and antibiotics in infancy, influences the risk of overweight in later childhood. This effect may potentially be explained by an impact on establishment and diversity of the microbiota.

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“…Given the known importance of the vaginal microbiome for female sexual and reproductive health and their role as microbial colonists for newborns (Tannock et al, 1990;Mandar and Mikelsaar, 1996;Leitich and Kiss, 2007;CDC, 2009;Biasucci et al, 2010;DominguezBello et al, 2010;Marrazzo et al, 2010), host-vaginal microbiome interactions could comprise a strong selection force having a pivotal role in the evolution of humans and other primates. Primates are ideal hosts for studying variation in vaginal microbiota, because primate species differ markedly in their diet, anatomy, mating systems, gestational durations, birthing difficulties, and commensurate risks of maternal injury and subsequent infection (Rosenberg and Trevathan, 2002;Campbell et al, 2011).…”

Section: Introductionmentioning

confidence: 99%

Primate vaginal microbiomes exhibit species specificity without universal Lactobacillus dominance

et al. 2014

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Bacterial communities colonizing the reproductive tracts of primates (including humans) impact the health, survival and fitness of the host, and thereby the evolution of the host species. Despite their importance, we currently have a poor understanding of primate microbiomes. The composition and structure of microbial communities vary considerably depending on the host and environmental factors. We conducted comparative analyses of the primate vaginal microbiome using pyrosequencing of the 16S rRNA genes of a phylogenetically broad range of primates to test for factors affecting the diversity of primate vaginal ecosystems. The nine primate species included: humans (Homo sapiens), yellow baboons (Papio cynocephalus), olive baboons (Papio anubis), lemurs (Propithecus diadema), howler monkeys (Alouatta pigra), red colobus (Piliocolobus rufomitratus), vervets (Chlorocebus aethiops), mangabeys (Cercocebus atys) and chimpanzees (Pan troglodytes). Our results indicated that all primates exhibited host-specific vaginal microbiota and that humans were distinct from other primates in both microbiome composition and diversity. In contrast to the gut microbiome, the vaginal microbiome showed limited congruence with host phylogeny, and neither captivity nor diet elicited substantial effects on the vaginal microbiomes of primates. Permutational multivariate analysis of variance and Wilcoxon tests revealed correlations among vaginal microbiota and host species-specific socioecological factors, particularly related to sexuality, including: female promiscuity, baculum length, gestation time, mating group size and neonatal birth weight. The proportion of unclassified taxa observed in nonhuman primate samples increased with phylogenetic distance from humans, indicative of the existence of previously unrecognized microbial taxa. These findings contribute to our understanding of host-microbe variation and coevolution, microbial biogeography, and disease risk, and have important implications for the use of animal models in studies of human sexual and reproductive diseases.

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Mode of delivery affects the bacterial community in the newborn gut

Cited by 426 publications

References 31 publications

Visceral Pain and Gastrointestinal Microbiome

Visceral Pain and Gastrointestinal Microbiome

Childhood overweight after establishment of the gut microbiota: the role of delivery mode, pre-pregnancy weight and early administration of antibiotics

Primate vaginal microbiomes exhibit species specificity without universal Lactobacillus dominance

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