Mode of in vitro interaction of mercuric mercury with selenite to form high-molecular weight substance in rabbit blood

Naganuma, Akira; Imura, Nobumasa

doi:10.1016/0009-2797(83)90111-4

Cited by 27 publications

(8 citation statements)

References 36 publications

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“…However, similar high molecular weight complexes of 203Hg and 75Se to those observed in the plasma of rabbits administered 203Hg-HgC1 2 and 75Se-Na2Se03 were fom1ed in rabbit plasma incubated with both compounds in the presence of glutathione (Naganuma and Imura, 1983).…”

Section: Factors Necessary For Complex Formation In the Bloodmentioning

confidence: 51%

“…These results indicate that glutathione isessential for the formation of complexes containing equimolar amounts of Hg and Se with proteins in rabbit blood. Glutathione is probably needed for reducing selenite to the level of selenide, which may easily interact with mercuric ion and proteins to form high molecular weight complexes (Naganuma and Imura, 1983).…”

Section: Factors Necessary For Complex Formation In the Bloodmentioning

confidence: 99%

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Possible Mechanism of Detoxifying Effect of Selenium on the Toxicity of Mercury Compounds

Imura

Naganuma

1991

Advances in Mercury Toxicology

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Co-administration of selenium compounds with mercuric mercury resulted in remarkable depression of acute toxicity of mercury through 1) reduction of mercury accumulation in the kidneys, a major target of acute toxicity of inorganic mercury, by forming high molecular weight complexes consisting of Hg, Se and proteins in the blood, which were hardly filtered through glomerulus; 2) elongation of retention of mercury and selenium as inert high molecular weight complexes in the blood, especially in the erythrocytes; 3) fom1ation of stable and non-diffusible complexes of Hg and Se in various organs such as the liver and kidneys.Methylmercury was found to fom1 a complex with selenium, bis(methylmercuric) selenide (BMS) , in various tissues on concurrent administration with selenite.However, the reduction of methylmercury toxicity by selenium as reported in numerous papers seems to be hardly explainable by the formation of BMS which showed a relatively low stability in the blood and other tissues.Using the assay methods developed in the studies described above to detect interactions between selenium and other metals, we indicated that more than 18 metal ions might be subjected to interactions with selenium in animal body, showing important roles of this essential metalloid as a modifying factor of metal toxicity. Although, according to the experimental data so far obtained, selenium appears not to 275 T. Suzuki et al. (eds.), Advances in Mercury Toxicology

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Section: Factors Necessary For Complex Formation In the Bloodmentioning

confidence: 51%

Section: Factors Necessary For Complex Formation In the Bloodmentioning

confidence: 99%

Possible Mechanism of Detoxifying Effect of Selenium on the Toxicity of Mercury Compounds

Imura

Naganuma

1991

Advances in Mercury Toxicology

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“…Moreover, it has been reported that the Amazon population is highly exposed to mercury (Hg) from diet [31,32,43,44], and high Se intake may counterpoise Hginduced toxic effects because they interact to form the selenite-dimethylmercury complex, which is unstable in blood and in other tissues [45]. effects of higher Se levels on motor performance [46] and reduced risk for cataracts [47], Se toxicity may be associated with longer-term disturbances, such as diabetes and cardiovascular disease [2,41,48], and further study is warranted to fully establish the long-term safety of Se supplementation through diet.…”

Section: A C C E P T E D Accepted Manuscriptmentioning

confidence: 99%

Selenium status in preschool children receiving a Brazil nut–enriched diet

Martens¹,

Cardoso

Hare

et al. 2015

Nutrition

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“…Presence of Hg-selenoproteins compounds was suggested in the liver of striped dolphins [41]. In experimental animals dosed with Hg and Se, equimolar amounts of Hg and Se have been observed in high-molecular-weight substances (HMWS) of hepatic cytosol and in plasma protein [42][43][44][45][46]. Similarly, Se also detoxifies Cd, Ag, and Cu through their interaction [47][48][49].…”

Section: Introductionmentioning

confidence: 99%

Association of heavy metals with metallothionein and other proteins in hepatic cytosol of marine mammals and seabirds

Ikemoto

Kunito

Anan

et al. 2004

Enviro Toxic and Chemistry

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Distribution of Cu, Zn, Cd, Ag, Hg, and Se were determined in hepatocytosol of northern fur seals (Callorhinus ursinus), black-footed albatrosses (Diomedea nigripes), and Dall's porpoises (Phocoenoides dalli). Copper, Zn, and Cd were accumulated preferentially in metallothionein (MT) fraction and their contents in MT fraction increased with the amounts in the hepatocytosol. Silver was bound to both high-molecular-weight substances (HMWS) and MT in the hepatocytosol for all three species, whereas the distribution of Ag in the cytosol was different among the three species. In northern fur seals, Ag mainly was bound to MT, whereas it mainly was associated with HMWS in Dall's porpoises. In contrast, Ag was distributed almost equally in both HMWS and MT for black-footed albatrosses. Mercury content in HMWS and Se content in HMWS and low-molecular-weight substances (LMWS) increased with their contents in hepatocytosol for all the three species. A significant positive correlation was found between Se and Hg contents in high-molecular weight (HMW) fraction in cytosol. The molar ratio of Hg and Se was close to unity in HMW fraction of the specimens with high Hg concentration in cytosol, implying that the Hg-Se complex was bound to the HMWS. Analysis of metals in the hepatocytosol by high-performance liquid chromatography/inductively coupled plasma-mass spectrometry (HPLC/ICP-MS) suggests that multiple isoforms of MT are present in hepatocytosol of the three species and that the metal profiles in hepatocytosols are different among the species. To our knowledge, this is the first report on the association of Ag with HMWS and MT in hepatocytosol of marine mammals and seabirds. Also, distribution and interaction of Hg and Se were investigated for the first time in hepatocytosol of the higher trophic marine animals.

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Mode of in vitro interaction of mercuric mercury with selenite to form high-molecular weight substance in rabbit blood

Cited by 27 publications

References 36 publications

Possible Mechanism of Detoxifying Effect of Selenium on the Toxicity of Mercury Compounds

Possible Mechanism of Detoxifying Effect of Selenium on the Toxicity of Mercury Compounds

Selenium status in preschool children receiving a Brazil nut–enriched diet

Association of heavy metals with metallothionein and other proteins in hepatic cytosol of marine mammals and seabirds

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