Model Based Approach to Study of Release Kinetics of the Drug Chlorhexidine from Hydrogels

Vitková, Zuzana; Oremusová, Jarmilla; Herdová, Petra; Vitko, Anton; Ivánková, Oľga

doi:10.3139/113.110350

Cited by 3 publications

(6 citation statements)

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“…To evaluate the in vitro OEO release and skin permeation processes, the respective experimental data were fitted to four currently used kinetic models for semisolids [60][61][62]:…”

Section: Data Analysis Of In Vitro Oeo Release and Permeation Studiesmentioning

confidence: 99%

Cutaneous Polymeric-Micelles-Based Hydrogel Containing Origanum vulgare L. Essential Oil: In Vitro Release and Permeation, Angiogenesis, and Safety Profile In Ovo

et al. 2023

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Origanum vulgare var. vulgare essential oil (OEO) is known as a natural product with multiple beneficial effects with application in dermatology. Oregano essential oil represents a potential natural therapeutic alternative for fibroepithelial polyps (FPs), commonly known as skin tags. Innovative formulations have been developed to improve the bioavailability and stability of essential oils. In this study, we aimed to evaluate the morphology of a polymeric-micelles-based hydrogel (OEO-PbH), the release and permeation profile of oregano essential oil, as well as to assess in vivo the potential effects on the degree of biocompatibility and the impact on angiogenesis in ovo, using a chick chorioallantoic membrane (CAM). Scanning electron microscopy (SEM) analysis indicated a regular aspect after the encapsulation process, while in vitro release studies showed a sustained release of the essential oil. None of the tested samples induced any irritation on the CAM and the limitation of the angiogenic process was noted. OEO-PbH, with a sustained release of OEO, potentially enhances the anti-angiogenic effect while being well tolerated and non-irritative by the vascularized CAM, especially on the blood vessels (BVs) in the presence of leptin treatment. This is the first evidence of in vivo antiangiogenic effects of a polymeric-micelle-loaded oregano essential oil, with further mechanistic insights for OEO-PbH formulation, involving leptin as a possible target. The findings suggest that the OEO-containing polymeric micelle hydrogel represents a potential future approach in the pathology of cutaneous FP and other angiogenesis-related conditions.

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“…To evaluate the in vitro OEO release and skin permeation processes, the respective experimental data were fitted to four currently used kinetic models for semisolids [60][61][62]:…”

Section: Data Analysis Of In Vitro Oeo Release and Permeation Studiesmentioning

confidence: 99%

Cutaneous Polymeric-Micelles-Based Hydrogel Containing Origanum vulgare L. Essential Oil: In Vitro Release and Permeation, Angiogenesis, and Safety Profile In Ovo

et al. 2023

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“…The amount of the released drug increases with the prolongation of the alkyl chain of the surfactant. From the obtained release curves were determined the release rate constants of the pseudo-first order kinetics in accordance with [ 16 ]. The obtained values are summarized in Table 2 .…”

Section: Resultsmentioning

confidence: 99%

“…Therefore, the obtained results will be used in ongoing research activities at the workplace of the authors. The aim of this research is to develop optimal control of drug liberation from semisolid dosage forms and computer simulation of the LADME process with possible prediction of the therapeutic effect [ 1 , 18 , 19 , 20 ].…”

Section: Discussionmentioning

confidence: 99%

“…The calculations of the rate constant of the drug chlorhexidine followed from the fact that the drug released in tiny amounts into the water. The release rate constant was calculated according the following equation [ 16 ]:

where: W t is the concentration of released drug in time t ; W sat is the saturated concentration, i.e., the concentration caused by the whole amount of the released drug from the hydrogel; K is a release rate constant.…”

Section: Methods and Computational Proceduresmentioning

confidence: 99%

“…Appropriate choices of auxiliary substances determine the first process of LADME, namely drug liberation, which in turn influences the subsequent processes, i.e., absorption, distribution, metabolism, and excretion. Therefore, the LADME process should be modelled and analyzed as a whole, which has been a long-lasting research subject of the authors [ 1 , 2 ]. Therefore, in those studies, various roles of surfactants have been studied, which are known to play a vital role not only in the process of LADME, but also in many processes of interest in both the fundamental and applied sciences [ 3 ].…”

Section: Introductionmentioning

confidence: 99%

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Association, Distribution, Liberation, and Rheological Balances of Alkyldimethylbenzylammonium Chlorides (C12–C16)

et al. 2017

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It is known that cationic surfactants have an antimicrobial effect and act as enhancers. This paper studies three cationic surfactants from the group of alkyldimethylbenzylammonium chlorides (dodecyl-, tetradecyl-, and hexadecyl). Interest is focused on the association of the surfactants with respect to temperature, partition balances and their influence on drug release, rheological properties, and the pH of hydrogels. The critical micelle concentrations (CMC) of the surfactants were estimated from dependencies of conductivity, density, spectrofluorimetry, and UV–VIS spectrophotometry on molarity in the temperature range of 25–50 °C. It was found that the temperature dependence of a CMC is U-shaped, with its minimum at 30 °C, and the CMC value decreases as the length of the chain increases. The pseudo-phase separation model was used for the calculation of various thermodynamic parameters, such as the Gibbs free energies (spontaneous process), enthalpies (exothermic process), and entropies of the micelles’ formation, CMCs, and the degree of counterion binding. All thermodynamic parameters, as functions of the temperature, were estimated. It was found that partition coefficients increase as the length of the alkyl chain and the pH = (5.0–7.0) increase. The influences of surfactants, below and above the CMC, on drug (chlorhexidine dihydrochloride) release from hydrogels, rheological properties, and pH at 30 °C were studied. Also, the amounts of the released drug increase as the alkyl chains of the surfactants prolongate. The amounts of the released drug with the surfactant below the CMC are greater than that above the CMC. All hydrogels (regardless of the length of the alkyl chain) exhibit a non-Newtonian pseudo-plastic flow. The results obtained will be used in the formulation of the drug and surfactants into dosage forms.

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Dehydroabietyl Glycidyl Ether Grafted Hydroxyethyl Chitosan: Synthesis, Characterization and Physicochemical Properties

Wang

Cai

Zhang

et al. 2019

Tenside Surfactants Detergents

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A series of novel polymeric nonionic surfactants based on water-soluble N,O-hydroxyethyl chitosan (N,O-HECTS) and dehydroabietyl glycidyl ether (DAGE), DAGE-g-N,O-HECTSs, were synthesized by an additive reaction between N,O-HECTS and DAGE. The structures of DAGE-g-N,O-HECTSs were characterized by FT-IR and 1H NMR. The substitution degree of hydroxyethylation (DSHE) of N,O-HECTS and the grafting degree (DG) of DAGE onto N,O-HECTS for DAGE-g-N,O-HECTSs were determined by elemental analysis. The surface activities of DAGE-g-N,O-HECTSs in aqueous solution were investigated by measuring the surface tension. The experimental results showed that the degree of grafting (DG) of DAGE-gN,O-HECTSs could have a significant impact on their critical micelle concentrations (CMCs) and surface tensions at the CMC (γCMC), but the DG of DAGE-g-N,O-HECTSs had almost no effect on the minimum of surface tensions (γmin). When using the DAGE-g-N,O-HECTSs as emulsifier, the increase in DG had a favorable influence on the stability of an emulsion of water and benzene. At a DG greater than 40.45%, the emulsifying power of DAGE-g-N,O-HECTS exceeded that of Tween-60.

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Model Based Approach to Study of Release Kinetics of the Drug Chlorhexidine from Hydrogels

Cited by 3 publications

References 4 publications

Cutaneous Polymeric-Micelles-Based Hydrogel Containing Origanum vulgare L. Essential Oil: In Vitro Release and Permeation, Angiogenesis, and Safety Profile In Ovo

Cutaneous Polymeric-Micelles-Based Hydrogel Containing Origanum vulgare L. Essential Oil: In Vitro Release and Permeation, Angiogenesis, and Safety Profile In Ovo

Association, Distribution, Liberation, and Rheological Balances of Alkyldimethylbenzylammonium Chlorides (C12–C16)

Dehydroabietyl Glycidyl Ether Grafted Hydroxyethyl Chitosan: Synthesis, Characterization and Physicochemical Properties

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