Model-based assessment for human inhalation exposure risk to airborne nano/fine titanium dioxide particles

Liao, Chung‐Min; Chiang, Yu-Hui; Chio, Chia-Pin

doi:10.1016/j.scitotenv.2008.09.028

Cited by 47 publications

(36 citation statements)

References 41 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Especially for the lung, ''partial'' models were developed without the involvement of blood, dividing the lung into subcompartments and describing the NP transfer between them (Sturm 2007;Shelley et al 2008;Liao et al 2008).…”

Section: Physiologically Based Pharmacokinetic Modeling Of Nanomaterialsmentioning

confidence: 99%

Toxico-/biokinetics of nanomaterials

et al. 2012

View full text Add to dashboard Cite

Nanomaterials (NM) offer great technological advantages but their risks to human health are still under discussion. For toxicological testing and evaluation, information on the toxicokinetics of NM is essential as it is different from that of most other xenobiotics. This review provides an overview on the toxicokinetics of NM available to date. The toxicokinetics of NM depends on particle size and shape, protein binding, agglomeration, hydrophobicity, surface charge and protein binding. In most studies with topical skin application, unintentional permeation and systemic availability were not observed; permeation for some NM with distinct properties was observed in animals. Upon inhalation, low levels of primary model nanoparticles became systemically available, but many real-world engineered NM aggregate in aerosols, do not disintegrate in the lung, and do not become systemically available. NM are prone to lymphatic transport, and many NM are taken up by the mononuclear phagocyte system (MPS) acting as a depot. Their half-life in blood depends on their uptake by MPS rather than their elimination from the body. NM reaching the GI tract are excreted with the feces, but of some NM low levels are absorbed and become systemically available. Some quantum dots were not observably excreted in urine nor in feces. Some model quantum dots, however, were efficiently excreted by the kidneys below, but not above 5-6 nm hydrodynamic diameter, while nanotubes 20-30 nm thick and 500-2,000 nm long were abundant in urine. NM are typically not metabolized. Some NM cross the blood-brain barrier favored by a negative surface charge.

show abstract

Section: Physiologically Based Pharmacokinetic Modeling Of Nanomaterialsmentioning

confidence: 99%

Toxico-/biokinetics of nanomaterials

et al. 2012

View full text Add to dashboard Cite

show abstract

“…Some pro-inflammatory effects of TiO 2 NPs were observed in vitro in pulmonary cells and in animals following lung instillation. In fact, the vast majority of studies investigating the inflammatory properties of nanomaterials target pulmonary cells, airways and lungs [5,[9][10][11]. However, NPs can also gain entry into human systems through ingestion and via dermal routes [6,12].…”

Section: Introductionmentioning

confidence: 99%

Titanium dioxide (TiO2) nanoparticles induce neutrophil influx and local production of several pro-inflammatory mediators in vivo

Gonçalves

Girard

2011

International Immunopharmacology

View full text Add to dashboard Cite

“…Nevertheless, our findings point out that TiO 2 NP production workers have significant risk on cytotoxicity response at relatively high airborne TiO 2 anatase NP concentrations at size 10-30 nm". However, this conclusion is based on a number of errors and misunderstandings some of which were also made in a previous risk assessment [2] and described by Tomenson and Morfeld [3].…”

mentioning

confidence: 93%

“…Somewhat surprisingly, Liao et al [7] stated that it was appropriate to describe "mg m −3 yr" as yearly averaged concentration based on "insufficient information" contained in the reports by Boffetta et al [4,8], and they did not correct this obvious error in their earlier risk assessment [2]. However, Table 2.8 of Boffetta et al [8] clearly indicates that 7.75 mg m −3 year is the median "estimated cumulative exposure to respirable TiO 2 dust" of surface treatment workers, and the report contains a long and comprehensive description of how the cumulative exposures of workers were estimated.…”

mentioning

confidence: 99%