Model-based optimized steering and focusing of local magnetic particle concentrations for targeted drug delivery

Perspective: magnetic nanoparticles in theranostic applications

“…As an additional check, the techniques from multicolor MPI could be exploited to estimate the temperature of the sample. Similarly, in recent work, we showed the advantages of linking predictions of a magnetic nanoparticle targeting model to a control algorithm of the coils to generate specific magnetic forces on the particles 118 . This approach made it possible to mitigate dispersion of the nanoparticles and to bring them to their desired location, following the shortest path under minimal coil energy requirements and keeping in mind the limitations of the coils.…”

Magnetic Nanoparticles: An Optimization Design Approach for a Targeted Drug Release Using an AC Magnetic Field

“…where m p is the particle mass, v is the particle's velocity, F m is the magnetic force, F D is the hydrodynamic drag force, F L the Volume 1 | Issue 2 | 6 of 9 Int J Biomed Res Prac, 2021 hydrodynamic lift force, F g the gravitational force, F b the buoyant force, R is a random Brownian force and finally d, represents the particle interaction forces [8].…”

“…The flux contains a diffusive component given by Fick's law jD = -D∇c (D is the diffusion coefficient) [8].…”

“…To obtain C´=A .c Where c will be the vector of concentrations at each of the four sides, A, will be a matrix containing magnetic and fluid dynamics [8].…”

Construction of Fe3O4-Loaded Mesoporous Carbon Systems for Controlled Drug Delivery

“…4−6 Compared to nonmagnetic vehicles, a major advantage of Fe 3 O 4 carriers is the significant improvement of drug accumulation efficiency in the tumor location. 7 However, easy aggregation of Fe 3 O 4 nanoparticles limits their application in the field of drug delivery.…”