Model-based prediction of optogenetic sound encoding in the human cochlea by future optical cochlear implants

Khurana, Lakshay; Keppeler, Daniel; Jablonski, Lukasz; Moser, Tobias

doi:10.1016/j.csbj.2022.06.061

Cited by 12 publications

(6 citation statements)

References 58 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…This suggests that a novel modality of stimulation for artificial hearing, such as optical stimulation, would be warranted. In vivo and in silico preclinical studies confirmed the expectation that the oCI achieves near physiological (i.e., acoustic/natural hearing) spectral selectivity (Dieter et al, 2019(Dieter et al, , 2020bKeppeler et al, 2020;Khurana et al, 2022), fundamentally exceeding that of state-of-the-art eCI, thereby promising more independent stimulation channels in the oCI than amenable to the eCI (≤10). Moreover, preclinical studies suggest an increased output dynamic range using the oCI over the eCI (Bali et al, 2021).…”

Section: Discussionmentioning

confidence: 53%

Patient perspectives on the need for improved hearing rehabilitation: A qualitative survey study of German cochlear implant users

et al. 2023

Self Cite

View full text Add to dashboard Cite

BackgroundThe electrical cochlear implant (eCI) partially restores hearing in individuals affected by profound hearing impairment (HI) or deafness. However, the limited resolution of sound frequency coding with eCIs limits hearing in daily situations such as group conversations. Current research promises future improvements in hearing restoration which may involve gene therapy and optical stimulation of the auditory nerve, using optogenetics. Prior to the potential clinical translation of these technologies, it is critical that patients are engaged in order to align future research agendas and technological advancements with their needs.MethodsHere, we performed a survey study with hearing impaired, using an eCI as a means of hearing rehabilitation. We distributed a questionnaire to 180 adult patients from the University Medical Center Göttingen’s Department of Otolaryngology who were actively using an eCI for 6 months or more during the time of the survey period. Questions revolved around patients needs, and willingness to accept hypothetical risks or drawbacks associated with an optical CI (oCI).ResultsEighty-one participants responded to the questionnaire; 68% were greater than 60 years of age and 26% had bilateral eCIs. Participants expressed a need for improving the performance beyond that experienced with their current eCI. Primarily, they desired improved speech comprehension in background noise, greater ability to appreciate music, and more natural sound impression. They expressed a willingness for engaging with new technologies for improved hearing restoration. Notably, participants were least concerned about hypothetically receiving a gene therapy necessary for the oCI implant; but expressed greater reluctance to hypothetically receiving an implant that had yet to be evaluated in a human clinical trial.ConclusionThis work provides a preliminary step in engaging patients in the development of a new technology that has the potential to address the limitations of electrical hearing rehabilitation.

show abstract

Section: Discussionmentioning

confidence: 53%

Patient perspectives on the need for improved hearing rehabilitation: A qualitative survey study of German cochlear implant users

et al. 2023

Self Cite

View full text Add to dashboard Cite

show abstract

“…In the human cochlea, where there is a greater distance between the emitter and the neural tissue, optical arrays of micro-LEDs are still predicted to significantly reduce the spread of activation in the cochlea to 0.4-1.0 octaves, up to fourfold lower than electrical stimulation [93,94]. While modelling data suggests waveguides could provide even greater spectral selectivity [95], the fraxicon technology presented here could potentially be used to focus the emission cone and improve the spectral resolution provided by LEDs in the human cochlea.…”

Section: Discussionmentioning

confidence: 99%

Fraxicon for Optical Applications with Aperture ∼1 mm: Characterisation Study

Mu,

Smith,

et al. 2024

Nanomaterials

View full text Add to dashboard Cite

Emerging applications of optical technologies are driving the development of miniaturised light sources, which in turn require the fabrication of matching micro-optical elements with sub-1 mm cross-sections and high optical quality. This is particularly challenging for spatially constrained biomedical applications where reduced dimensionality is required, such as endoscopy, optogenetics, or optical implants. Planarisation of a lens by the Fresnel lens approach was adapted for a conical lens (axicon) and was made by direct femtosecond 780 nm/100 fs laser writing in the SZ2080™ polymer with a photo-initiator. Optical characterisation of the positive and negative fraxicons is presented. Numerical modelling of fraxicon optical performance under illumination by incoherent and spatially extended light sources is compared with the ideal case of plane-wave illumination. Considering the potential for rapid replication in soft polymers and resists, this approach holds great promise for the most demanding technological applications.

show abstract

“…In the human cochlea, where there is a greater distance between the emitter and the neural tissue, optical arrays of micro-LEDs are still predicted to significantly reduce the spread of activation in the cochlea to 0.4-1.0 octaves, up to 4-fold lower than electrical stimulation [35,36]. While modelling data suggests waveguides could provide even greater spectral selectivity [37], the fraxicon technology presented here could potentially be used to focus the emission cone and improve the spectral resolution provided by LEDs in the human cochlea.…”

Section: Discussionmentioning

confidence: 99%

Fraxicon for Optical Applications with Aperture ∼1 mm

Mu,

Smith,

et al. 2023

Preprint

View full text Add to dashboard Cite

Emerging applications of optical technologies are driving the development of miniaturised light sources, which in turn require the fabrication of matching micro-optical elements with sub-1 mm cross sections and high optical quality. This is particularly challenging for spatially-constrained biomedical applications where reduced dimensionality is required, such as endoscopy, optogenetics, or optical implants. Planarisation of a lens by the Fresnel lens approach was adapted for a conical lens (axicon) and was made by direct femtosecond 780 nm/100 fs laser writing in SZ2080™polymer with photo-initiator. Optical characterisation of the positive and negative fraxicons is presented. Numerical modeling of fraxicon optical performance under illumination by incoherent and spatially extended light sources is compared with the ideal case of plane wave illumination. Considering the potential for rapid replication in soft polymers and resists, this approach holds great promise for the most demanding technological applications.

show abstract

Model-based prediction of optogenetic sound encoding in the human cochlea by future optical cochlear implants

Cited by 12 publications

References 58 publications

Patient perspectives on the need for improved hearing rehabilitation: A qualitative survey study of German cochlear implant users

Patient perspectives on the need for improved hearing rehabilitation: A qualitative survey study of German cochlear implant users

Fraxicon for Optical Applications with Aperture ∼1 mm: Characterisation Study

Fraxicon for Optical Applications with Aperture ∼1 mm

Contact Info

Product

Resources

About