“…Furthermore, for big size equipments an isobaric condition can never be reached. Although pressure come-up times are usually short, microbial inactivation during that period could be significant (see for example, Ahn et al, 2007;Margosch, Gazle, Ehrmann, & Vogel, 2004;Patazca, Koutchma, & Ramaswamy, 2006;Rajan et al, 2006;Valdramidis et al, 2007). For these cases, the mentioned approach is not applicable.…”