Model for estimating the healthcare costs and capacity of intensive care units in Italy in the treatment of patients with COVID-19: remdesivir impact assessment

Ruggeri, Matteo; Signorini, Alessandro; Drago, Carlo; Rosiello, Francesco; Marchetti, M

doi:10.33393/abtpn.2020.2213

Cited by 13 publications

(7 citation statements)

References 8 publications

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“…Behind the social and economic crisis, the Italian National Health System (NHS) collapsed because of the exponential increase of hospitalized patients [6] [7]. It is quite evident, however, how the pandemic showed the limited economic resources made available by the NHS, which had to deal with the excessive burden placed on the shoulders of health workers (from doctors to nurses and other professional figures) in terms of working conditions [8] [9].…”

Section: The Health Crisis and The Organization Of Care In Italymentioning

confidence: 99%

COVID-19 Pandemic Waves in Italy: An Epidemiological Overview about Infections, Swabs and Death Rates

Zirilli¹,

Limonti²,

Alibrandi³

2022

OJEpi

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Introduction: On March 11, 2020, the World Health Organization (WHO) declared that the entire World was overrun by a pandemic. Science has managed, in a short time, to characterize a new disease, sequence a new viral genome, develop diagnostics, produce treatment protocols and establish the efficacy of drugs and vaccines in randomized controlled trials. In this paper we have dealt with different topics regarding the pandemic linked to COVID-19. Objectives: Aim of this paper is to compare the number of deaths attributable to COVID-19, that occurred in the different Italian macro-areas, in the different pandemic waves; we studied the trend of the curves relating to the proportion of deaths to the number of infected in the Italian macro-areas for the pandemic waves and analysed the mortality data, focusing on the Italian context and comparing it with other foreign countries. We examined the data regarding swabs, hospitalizations, home isolation, admissions to intensive care and deaths registered in pandemic period. Results: Geographically, Italy was differently affected by the pandemic. Northern Italy was the most affected area. In comparison with some foreign countries, Italy is one of the nations that paid the most in terms of deaths, due to: delays in understanding the seriousness of the emergency; the slow management in the tracking systems of contagions; the high number of hospitalizations; a corporate organizational system poorly planned. Conclusion: The years 2020 and 2021 have been dramatic and unprecedented. The year 2021 was the year of redemption, where, despite social, economic and health difficulties, thanks to mass vaccination, we were able to give a real strong response to the pandemic. Trust in science has led to a drastic decrease in mortality throughout the world.

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Section: The Health Crisis and The Organization Of Care In Italymentioning

confidence: 99%

COVID-19 Pandemic Waves in Italy: An Epidemiological Overview about Infections, Swabs and Death Rates

Zirilli¹,

Limonti²,

Alibrandi³

2022

OJEpi

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“…The presence of one or more CVD increases LOS and, subsequently, inflates costs (every hospitalization day costs EUR 582.38 in medium-intensity care units and EUR 1278.50 in high-intensity ones) [37,[39][40][41][42]. On average, male COVID-19 patients stay at least one day more than female patients and, consequently, lead to higher costs.…”

Section: Resultsmentioning

confidence: 99%

Polypharmacy Management in a Gender Perspective: At the Heart of the Problem: Analysis of Major Cardiac Diseases, SARS-CoV-2 Affection and Gender Distribution in a Cohort of Patients in Internal Medicine Ward

Pietrantonio

Ciamei²,

Vinci

et al. 2023

IJERPH

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Background: COVID-19 patients with any pre-existing major cardio-vascular disease (CVD) are at the highest risk of viral infection and of developing severe disease. The pathophysiological mechanism is characterized by the viral link to angiotensin-converting enzyme 2 (ACE2) and the involvement of the endothelial system with the release of cytokines and the inflicting of direct damage to the myocardium, the induction of microthrombosis, and the initiation of alterations in oxygen diffusion. The aim of the study is to analyze the clinical course and outcomes in patients (gender-stratified) with pre-existing major CVD. Methods: Out of the 1833 (973 M/860 F) patients admitted to the Internal Medicine COVID-19 Unit of “Castelli Hospital”, Lazio, Italy, from 1 January 2021 to 31 December 2021, 600 patients (320 M/280 F) with a mean age of 77 (78.6 M/75.1 F) previously had CVD. Demographic characteristics, length of the stay (LOS) and oxygen therapy were evaluated. Results: All of the CVD COVID-19 patients underwent non-invasive ventilation (NIV). CVD was linked with increased LOS (21 days F/22 M) compared to no CVD (19 days). In total, 32.7% of total patients had major CVD. Conclusions: Timely identification and evaluation of patients with pre-existing major CVD are fundamental for adequate treatment based on gender, severity, state of illness and for risk reduction.

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“…The practical applications and digital health techniques that have emerged recently are numerous, and continue to represent a concrete opportunity to address the critical issues in health systems, offering a wide range of possibilities: Decreasing the timing of certain clinical therapies and treatments [ 18 ]; Enhancing the coverage in terms of healthcare information, with a particular emphasis on information regarding the methods of prevention of various medical pathologies [ 19 ]; Improving the coverage and quality of health services [ 20 ]; Increasing the level of accuracy in diagnoses and the degree of precision in medical procedures [ 21 ]; Increasing the efficiency, effectiveness, and sustainability of healthcare tools [ 22 ]; Italian territories present a profound absence of digitalization, and a peculiar dispersion of population and services among small towns and large cities, with several instances of service availability imbalance [ 23 ]. …”

Section: Introductionmentioning

confidence: 99%

“…Enhancing the coverage in terms of healthcare information, with a particular emphasis on information regarding the methods of prevention of various medical pathologies [ 19 ];…”

Section: Introductionmentioning

confidence: 99%

Intra- and Extra-Hospitalization Monitoring of Vital Signs—Two Sides of the Same Coin: Perspectives from LIMS and Greenline-HT Study Operators

Pietrantonio,

Vinci,

Maurici

et al. 2023

Sensors

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Background: In recent years, due to the epidemiological transition, the burden of very complex patients in hospital wards has increased. Telemedicine usage appears to be a potential high-impact factor in helping with patient management, allowing hospital personnel to assess conditions in out-of-hospital scenarios. Methods: To investigate the management of chronic patients during both hospitalization for disease and discharge, randomized studies (LIMS and Greenline-HT) are ongoing in the Internal Medicine Unit at ASL Roma 6 Castelli Hospital. The study endpoints are clinical outcomes (from a patient’s perspective). In this perspective paper, the main findings of these studies, from the operators’ point of view, are reported. Operator opinions were collected from structured and unstructured surveys conducted among the staff involved, and their main themes are reported in a narrative manner. Results: Telemonitoring appears to be linked to a reduction in side-events and side-effects, which represent some of most commons risk factors for re-hospitalization and for delayed discharge during hospitalization. The main perceived advantages are increased patient safety and the quick response in case of emergency. The main disadvantages are believed to be related to low patient compliance and an infrastructural lack of optimization. Conclusions: The evidence of wireless monitoring studies, combined with the analysis of activity data, suggests the need for a model of patient management that envisages an increase in the territory of structures capable of offering patients subacute care (the possibility of antibiotic treatments, blood transfusions, infusion support, and pain therapy) for the timely management of chronic patients in the terminal phase, for which treatment in acute wards must be guaranteed only for a limited time for the management of the acute phase of their diseases.

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Model for estimating the healthcare costs and capacity of intensive care units in Italy in the treatment of patients with COVID-19: remdesivir impact assessment

Cited by 13 publications

References 8 publications

COVID-19 Pandemic Waves in Italy: An Epidemiological Overview about Infections, Swabs and Death Rates

COVID-19 Pandemic Waves in Italy: An Epidemiological Overview about Infections, Swabs and Death Rates

Polypharmacy Management in a Gender Perspective: At the Heart of the Problem: Analysis of Major Cardiac Diseases, SARS-CoV-2 Affection and Gender Distribution in a Cohort of Patients in Internal Medicine Ward

Intra- and Extra-Hospitalization Monitoring of Vital Signs—Two Sides of the Same Coin: Perspectives from LIMS and Greenline-HT Study Operators

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