2020
DOI: 10.3390/pr8101209
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Model-Free Extremum Seeking Control of Bioprocesses: A Review with a Worked Example

Abstract: Uncertainty is a common feature of biological systems, and model-free extremum-seeking control has proved a relevant approach to avoid the typical problems related to model-based optimization, e.g., time- and resource-consuming derivation and identification of dynamic models, and lack of robustness of optimal control. In this article, a review of the past and current trends in model-free extremum seeking is proposed with an emphasis on finding optimal operating conditions of bioprocesses. This review is illust… Show more

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Cited by 24 publications
(9 citation statements)
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References 89 publications
(130 reference statements)
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“…This first assumption implies that (i) driving the system to a stable steady-state manifold is feasible and that (ii) the system in the steady state is likely to be a convex/concave function of the input. In bioprocess applications, these statements find their justifications in the bifurcation analysis developed in [23], which can be considered as a basis for further investigations of bioprocesses [24]. Assumption 2.…”
Section: A Diso Adaptive Slope-seeking Strategymentioning
confidence: 99%
“…This first assumption implies that (i) driving the system to a stable steady-state manifold is feasible and that (ii) the system in the steady state is likely to be a convex/concave function of the input. In bioprocess applications, these statements find their justifications in the bifurcation analysis developed in [23], which can be considered as a basis for further investigations of bioprocesses [24]. Assumption 2.…”
Section: A Diso Adaptive Slope-seeking Strategymentioning
confidence: 99%
“…The body frame is specified by the quadrotor orientation, with the rotor axes positioned in the positive direction and the arms positioned in the and directions. The quadrotor attitude is concluded by three angles, which are terms, roll-φ, pitch-θ, and yaw-ψ [14,20]. The equations of quadrotor linear motion are [21]:…”
Section: Modelling Of Quadrotormentioning
confidence: 99%
“…Equations (20,21,22) and (27, 28 29) represent linear motions and angular motions of the quadrotor, respectively.…”
Section: Modelling Of Quadrotormentioning
confidence: 99%
“…This is mainly attributed to the prohibitively slow convergence when using such model‐free methods. For example, in a recent study comparing different extremum seeking control algorithms for a bioprocess, the fastest convergence achieved was around 25 h, (with some other approaches even taking 1000 h to converge) 10 11 .…”
Section: Introductionmentioning
confidence: 99%
“…For example, in a recent study comparing different extremum seeking control algorithms for a bioprocess, the fastest convergence achieved was around 25 h, (with some other approaches even taking 1000 h to converge). 10 Another model-free gradient estimation scheme applied to a bioprocess also took around 1000 h to converge. 11 The main bottleneck arises from the gradient estimation step.…”
mentioning
confidence: 99%