Model protein BSA adsorption onto novel magnetic chitosan/PVA/laponite RD hydrogel nanocomposite beads

Mahdavinia, Gholam Reza; Soleymani, Moslem; Etemadi, Hossein; Sabzi, Mohammad; Atlasi, Ziba

doi:10.1016/j.ijbiomac.2017.09.042

Cited by 96 publications

(27 citation statements)

References 53 publications

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“…Because hydrogels are biodegradable, biocompatible, and non-toxic, they have received great attention in various fields. Hydrogels can serve as biological drug delivery systems, cell encapsulation matrices, or scaffolds in regenerative medicine (Oliva et al, 2017 ; Mahdavinia et al, 2018 ). Hydrogel is considered to be an excellent carrier for EVs and may be capable of effectively delivering EVs to damaged tissues and prolonging their effects (Riau et al, 2019 ).…”

Section: Sustained Delivery Of Evsmentioning

confidence: 99%

Immunomodulation of MSCs and MSC-Derived Extracellular Vesicles in Osteoarthritis

Zhao

Sun

et al. 2020

Front. Bioeng. Biotechnol.

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Osteoarthritis (OA) has become recognized as a low-grade inflammatory state. Inflammatory infiltration of the synovium by macrophages, T cells, B cells, and other immune cells is often observed in OA patients and plays a key role in the pathogenesis of OA. Hence, orchestrating the local inflammatory microenvironment and tissue regeneration microenvironment is important for the treatment of OA. Mesenchymal stem cells (MSCs) offer the potential for cartilage regeneration owing to their effective immunomodulatory properties and anti-inflammatory abilities. The paracrine effect, mediated by MSC-derived extracellular vehicles (EVs), has recently been suggested as a mechanism for their therapeutic properties. In this review, we summarize the interactions between MSCs or MSC-derived EVs and OA-related immune cells and discuss their therapeutic effects in OA. Additionally, we discuss the potential of MSC-derived EVs as a novel cell-free therapy approach for the clinical treatment of OA.

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Section: Sustained Delivery Of Evsmentioning

confidence: 99%

Immunomodulation of MSCs and MSC-Derived Extracellular Vesicles in Osteoarthritis

Zhao

Sun

et al. 2020

Front. Bioeng. Biotechnol.

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“…The peak at 2925 cm −1 is assigned to the stretching vibration of asymmetric CH 2 groups. The peaks at 1090 and 810 cm −1 are the absorption peaks of CO and CC stretching vibrations, respectively . For gelatin, an obvious peak at 3439 cm −1 is assigned to stretching vibration of OH bonded to NH .…”

Section: Resultsmentioning

confidence: 95%

Synthesis of poly(acrylic acid)–Fe³⁺/gelatin/poly(vinyl alcohol) triple‐network supramolecular hydrogels with high toughness, high strength and self‐healing properties

Jing

Zhang

Liang

et al. 2019

Polymer International

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Hydrogels with good mechanical and self‐healing properties are of great importance for various applications. Poly(acrylic acid)–Fe3+/gelatin/poly(vinyl alcohol) (PAA‐Fe3+/Gelatin/PVA) triple‐network supramolecular hydrogels were synthesized by a simple one‐pot method of copolymerization, cooling and freezing/thawing. The PAA‐Fe3+/Gelatin/PVA triple‐network hydrogels exhibit superior toughness, strength and recovery capacity compared to single‐ and double‐network hydrogels. The mechanical properties of the synthesized hydrogels could be tailored by adjusting the compositions. The PAA‐Fe3+/Gelatin/PVA triple‐network hydrogel with 0.20 mmol Fe3+, 3% gelatin and 15% PVA could achieve good mechanical properties, the tensile strength and elongation at break being 239.6 kPa and 12.8 mm mm−1, respectively, and the compression strength reaching 16.7 MPa under a deformation of about 91.5%. The synthesized PAA‐Fe3+/Gelatin/PVA triple‐network hydrogels have good self‐healing properties owing to metal coordination between Fe3+ and carboxylic groups, hydrogen bonding between the gelatin chains and hydrogen bonding between the PVA chains. Healed PAA‐Fe3+(0.20)/Gelatin3%/PVA15% triple‐network hydrogels sustain a tensile strength of up to 231.4 kPa, which is around 96.6% of the tensile strength of the original samples. Therefore, the synthesized triple‐network supramolecular hydrogels would provide a new strategy for gel research and expand the potential for their application. © 2019 Society of Chemical Industry

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“…The application of this magnetic technology has important value in promoting bone tissue repair and regeneration. It could also provide an important theoretical basis for researchers and clinicians (Mahdavinia et al, 2018 ; Manjua et al, 2019 ; Parfenov et al, 2020 ). In recent years, based on the application of magnetic tissue engineering, multi-layer cell membranes have been developed, which will greatly promote the repair of bone tissue.…”

Section: Preparation Of Magnetic Nanomaterialsmentioning

confidence: 99%

Recent Advances of Magnetic Nanomaterials in Bone Tissue Repair

et al. 2020

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The magnetic field has been proven to enhance bone tissue repair by affecting cell metabolic behavior. Magnetic nanoparticles are used as biomaterials due to their unique magnetic properties and good biocompatibility. Through endocytosis, entering the cell makes it easier to affect the physiological function of the cell. Once the magnetic particles are exposed to an external magnetic field, they will be rapidly magnetized. The magnetic particles and the magnetic field work together to enhance the effectiveness of their bone tissue repair treatment. This article reviews the common synthesis methods, the mechanism, and application of magnetic nanomaterials in the field of bone tissue repair.

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Model protein BSA adsorption onto novel magnetic chitosan/PVA/laponite RD hydrogel nanocomposite beads

Cited by 96 publications

References 53 publications

Immunomodulation of MSCs and MSC-Derived Extracellular Vesicles in Osteoarthritis

Immunomodulation of MSCs and MSC-Derived Extracellular Vesicles in Osteoarthritis

Synthesis of poly(acrylic acid)–Fe³⁺/gelatin/poly(vinyl alcohol) triple‐network supramolecular hydrogels with high toughness, high strength and self‐healing properties

Recent Advances of Magnetic Nanomaterials in Bone Tissue Repair

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Model protein BSA adsorption onto novel magnetic chitosan/PVA/laponite RD hydrogel nanocomposite beads

Cited by 96 publications

References 53 publications

Immunomodulation of MSCs and MSC-Derived Extracellular Vesicles in Osteoarthritis

Immunomodulation of MSCs and MSC-Derived Extracellular Vesicles in Osteoarthritis

Synthesis of poly(acrylic acid)–Fe3+/gelatin/poly(vinyl alcohol) triple‐network supramolecular hydrogels with high toughness, high strength and self‐healing properties

Recent Advances of Magnetic Nanomaterials in Bone Tissue Repair

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Synthesis of poly(acrylic acid)–Fe³⁺/gelatin/poly(vinyl alcohol) triple‐network supramolecular hydrogels with high toughness, high strength and self‐healing properties