Accurate and stable prediction of icing thickness on transmission lines is of great significance for ensuring the safe operation of the power grid. In order to improve the accuracy and stability of icing prediction, an innovative prediction model based on the generalized regression neural network (GRNN) and the fruit fly optimization algorithm (FOA) is proposed. Firstly, a feature selection method based on the data inconsistency rate (IR) is adopted to select the optimal feature, which aims to reduce redundant input vectors. Then, the fruit FOA is utilized for optimization of smoothing factor for the GRNN. Lastly, the icing forecasting method FOA-IR-GRNN is established. Two cases in different locations and different months are selected to validate the proposed model. The results indicate that the new hybrid FOA-IR-GRNN model presents better accuracy, robustness, and generality in icing forecasting.