Model validity of randomised placebo-controlled trials of individualised homeopathic treatment

Mathie, Robert T.; Wassenhoven, Michel Van; Jacobs, Jennifer; Oberbaum, Menachem; Roniger, Helmut; Frye, Joyce; Manchanda, Rajkumar; Terzan, Laurence; Chaufferin, G; Dantas, Flávio; Fisher, Peter

doi:10.1016/j.homp.2015.02.004

Cited by 26 publications

(16 citation statements)

References 44 publications

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“…1 This is a follow-up to their previous pilot study demonstrating the method. 2 The method developed by Mathie and colleagues is based on 6 domains.…”

Section: Modelvaliditymentioning

confidence: 88%

The qualities of homeopathy

Fisher¹

2015

Homeopathy

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“…1 This is a follow-up to their previous pilot study demonstrating the method. 2 The method developed by Mathie and colleagues is based on 6 domains.…”

Section: Modelvaliditymentioning

confidence: 88%

The qualities of homeopathy

Fisher¹

2015

Homeopathy

Self Cite

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“…Reporting was in adherence with the CONSORT extension statement for randomized pilot trials [25] and RedHot [26] guidelines for reporting trials and Mathie’s criteria for model validity of homeopathic treatment [27, 28] (online suppl. files 1 and 2; see www.karger.com/doi/10.1159/000514524 for all online suppl.…”

Section: Methodsmentioning

confidence: 99%

Individualized Homeopathic Medicines in the Treatment of Generalized Anxiety Disorder: A Double-Blind, Randomized, Placebo-Controlled, Pilot Trial

Parewa

Burman

Brahma³

et al. 2021

Complement Med Res

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Introduction: Evidence favoring homeopathy in generalized anxiety disorder (GAD) remains scarce. The objective of this pilot trial was to test feasibility of a definitive trial in future. We also experimented whether individualized homeopathic medicines (IH) plus psychological counseling (PC) can produce significantly different effects beyond placebo plus PC in the treatment of GAD. Methods: A double-blind, randomized, placebo-controlled, parallel arm, pilot trial was conducted on 62 GAD patients at the National Institute of Homoeopathy, India. GAD-7 questionnaire and Hamilton Anxiety Scale (HAM-A) were used as the primary and secondary outcomes, respectively, measured at baseline and 3 months. Patients received either IH plus PC (n = 31) or identical-looking placebo plus PC (n = 31). Intention-to-treat sample was analyzed to detect group differences using unpaired t tests. Results: Recruitment and retention rates were 56 and 90%, respectively. Mean age was 31.5 years; 56.5% were male. GAD-7 reductions were non-significantly higher in IH than placebo (p = 0.122). Group differences on HAM-A favored IH significantly (p = 0.018). Effect sizes were small to medium. Calcarea carbonica was the most frequently indicated medicine. No serious adverse events happened. Conclusions: A small but positive direction of anxiolytic effect was observed favoring homeopathy over placebo. A definitive trial appeared feasible in future.

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“…The homeopathic model validity was evaluated by the six judgemental domains proposed by Mathie et al [24] (2015):…”

Section: Methodsmentioning

confidence: 99%

A Systematic Review of Controlled Trials of Homeopathy in Bronchial Asthma

et al. 2019

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Homeopathy is a controversial form of complementary therapy, but is widely practised to treat asthma. The aim of this systematic review is to evaluate the controlled trials of homeopathy in bronchial asthma. Relevant trials published between Jan 1, 1981, and Dec 31, 2016, were considered. Substantive research articles, conference proceedings, and master and doctoral theses were eligible. Methodology was assessed by Jadad’s scoring, internal validity by the Cochrane tool, model validity by Mathie’s criteria, and quality of individualization by Saha’s criteria. Sixteen trials were eligible. The majority were positive, especially those testing complex formulations. Methodological quality was diverse; 8 trials had “high” risk of bias. Model validity and individualization quality were compromised. Due to both qualitative and quantitative inadequacies, proofs supporting individualized homeopathy remained inconclusive. The trials were positive (evidence level A), but inconsistent, and suffered from methodological heterogeneity, “high” to “uncertain” risk of bias, incomplete study reporting, inadequacy of independent replications, and small sample sizes.

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Model validity of randomised placebo-controlled trials of individualised homeopathic treatment

Cited by 26 publications

References 44 publications

The qualities of homeopathy

The qualities of homeopathy

Individualized Homeopathic Medicines in the Treatment of Generalized Anxiety Disorder: A Double-Blind, Randomized, Placebo-Controlled, Pilot Trial

A Systematic Review of Controlled Trials of Homeopathy in Bronchial Asthma

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