Background: Cervical Uterine Cancer is a disease that explains the vulnerability in which women find themselves in terms of reproductive health with an impact on occupational health and public health, even though in Mexico the prevalence rate is lower than the other member countries. of the OECD, its impact on Human Development and Local Development shows the importance that the disease has in communities more than in cities where prevention policies through check-ups and medical examinations seem to stop the trend, but they show the lack opportunities and capabilities of health centers in rural areas.Target: To establish the reliability, validity and correlations between the variables reported in the literature with respect to their weighting in a public hospital.Method: A non-experimental, cross-sectional, and exploratory study was carried out with a non-probabilistic selection of 104 patients from a public hospital in the State of Mexico. The Scale of Psychosocial Variables Determining Adherence to Treatment of Cervical Cancer was constructed.Results: From a structural model [χ2 = 490.330 (28 df) p = 0.000; GFI = 0.927; CFI = 0.970; RMSEA = 0.003] the fit of the trajectories of determinant relationships in which knowledge influenced treatment adherence behavior was demonstrated (β = 0.50).Conclusion: The limits of the design, sampling and analysis of the study are noted, and it is recommended to include organizational and psychological variables based on theories of organizations and theories of personality.