Modeling 3D melt electrospinning writing by response surface methodology

Dayan, Cem Balda; Afghah, Ferdows; Okan, Burcu Saner; Yıldız, Mehmet; Menceloǵlu, Yusuf́ Z.; Çulha, Mustafa; Koç, Bahattin

doi:10.1016/j.matdes.2018.03.053

Cited by 59 publications

(49 citation statements)

References 48 publications

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“…For example, this method could reduce the fiber diameter from tens of microns down to 820 nm [47]. The collector or the syringe head could be movable in different directions [50,53]. One of the complexities of MEW setup is exposing heating element to high voltage electric field and how to put an insulator shield between the heating system and the syringe that was connected to high voltage to prevent any electrical interference [53,54].…”

Section: Principles and Challenges Of Mewmentioning

confidence: 99%

“…The collector or the syringe head could be movable in different directions [50,53]. One of the complexities of MEW setup is exposing heating element to high voltage electric field and how to put an insulator shield between the heating system and the syringe that was connected to high voltage to prevent any electrical interference [53,54]. Another challenge of applying high voltage to polymer melt is to fabricate a well-ordered structure as the tip-to-collector distance increases.…”

Section: Principles and Challenges Of Mewmentioning

confidence: 99%

“…In order to apply pressure, the majority of studies used a pneumatic system in their setup with higher control on the applying force [51], rather than that syringe pump [62], screw-extruding, and mechanical feeding [46,63]. The collectors are also divided into two general categories as static [53] and rotating [43]. The rotating cylindrical collectors enable various types of geometries, like tubular structures [3,64,65].…”

Section: Principles and Challenges Of Mewmentioning

confidence: 99%

“…Based on previously mentioned information, the processing parameters, such as collector speed and air pressure, significantly affect final structure and fiber diameter, as represented in Figure 2 [72]. The scaffold's architecture directly controls its mechanical and biological properties [53,[73][74][75]. Therefore, a significant amount of research in the literature has been focused on adjusting, understanding, and predicting the influence of process parameters on fiber diameter, experimentally, and numerically [42,53,62,73,[76][77][78][79].…”

Section: Principles and Challenges Of Mewmentioning

confidence: 99%

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Biomimicry in Bio-Manufacturing: Developments in Melt Electrospinning Writing Technology Towards Hybrid Biomanufacturing

et al. 2019

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Melt electrospinning writing has been emerged as a promising technique in the field of tissue engineering, with the capability of fabricating controllable and highly ordered complex three-dimensional geometries from a wide range of polymers. This three-dimensional (3D) printing method can be used to fabricate scaffolds biomimicking extracellular matrix of replaced tissue with the required mechanical properties. However, controlled and homogeneous cell attachment on melt electrospun fibers is a challenge. The combination of melt electrospinning writing with other tissue engineering approaches, called hybrid biomanufacturing, has introduced new perspectives and increased its potential applications in tissue engineering. In this review, principles and key parameters, challenges, and opportunities of melt electrospinning writing, and particularly, recent approaches and materials in this field are introduced. Subsequently, hybrid biomanufacturing strategies are presented for improved biological and mechanical properties of the manufactured porous structures. An overview of the possible hybrid setups and applications, future perspective of hybrid processes, guidelines, and opportunities in different areas of tissue/organ engineering are also highlighted.

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Section: Principles and Challenges Of Mewmentioning

confidence: 99%

Section: Principles and Challenges Of Mewmentioning

confidence: 99%

Section: Principles and Challenges Of Mewmentioning

confidence: 99%

Section: Principles and Challenges Of Mewmentioning

confidence: 99%

See 2 more Smart Citations

Biomimicry in Bio-Manufacturing: Developments in Melt Electrospinning Writing Technology Towards Hybrid Biomanufacturing

et al. 2019

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“…It can define the influence of independent variables individually or in combination on a response or a set of responses of a process, and simultaneously optimize the levels of experimental variables to attain the optimal performance of the system. Some examples of the RSM applications of optimization of chemical or biomedical process are enzymatic processing [21,22], heat transfer with nano-fluid [23,24], micro-extraction for pre-concentration [25], ultrasonicated adsorption and extraction process [26][27][28], cooling strategy for Li-ion batteries [29] and fibre manufacturing [30][31][32][33]. RSM is used to approximate the functional relationship between the independent variables and the process response based on experimental data, and it is valuable in obtaining insight of variable contributions through the coefficients in the developed model.…”

Section: Introductionmentioning

confidence: 99%

Empirical modelling and optimization of pressure-coupled infusion gyration parameters for the nanofibre fabrication

2019

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Pressure-coupled infusion gyration (PCIG) is a novel promising technique for economical and effective mass production of nanofibres with desirable geometrical characteristics. The average diameter of spun fibres significantly influences the structural, mechanical and physical properties of the produced fibre mats. Having a comprehensive understanding of the significant effects of PCIG experimental variables on the spun fibres is beneficial. In this work, response surface methodology was used to explore the interaction effects and the optimal PCIG experimental variables for achieving the desired morphological characteristics of fibres. The effect of experimental variables, namely solution concentration, infusion (flow) rate, applied pressure and rotational speed, was studied on the average fibre diameter and standard deviations. A numerical model for the interactional influences of experimental variables was developed and optimized with a nonlinear interior point method that can be used as a framework for selecting the optimal conditions to obtain poly-ethylene oxide fibres with desired morphology (targeted average diameter and narrow standard deviation). The adequacy of the models was verified by a set of validation experiments. The results proved that the predicted optimal conditions were able to achieve the average diameter that matched the pre-set desired value with less than 10% of difference.

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The Next Frontier in Melt Electrospinning: Taming the Jet

Robinson

Hutmacher

Dalton

2019

Adv Funct Materials

222

210

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There is a specialized niche for the electrohydrodynamic jetting of melts, from biomedical products to filtration and soft matter applications. The next frontier includes optics, microfluidics, flexible electronic devices, and soft network composites in biomaterial science and soft robotics. The recent emphasis on reproducibly direct‐writing continual molten jets has enabled a spectrum of contemporary microscale 3D objects to be fabricated. One strong suit of melt processing is the capacity for the jet to solidify rapidly into a fiber, thus fixing a particular structure into position. The ability to direct‐write complex and multiscaled architectures and structures has greatly contributed to a large number of recent studies, explicitly, toward fiber–hydrogel composites and fugitive inks, and has expanded into several biomedical applications such as cartilage, skin, periosteum, and cardiovascular tissue engineering. Following the footsteps of a publication that summarized melt electrowriting literature up to 2015, the most recent literature from then until now is reviewed to provide a continuous and comprehensive timeline that demonstrates the latest advances as well as new perspectives for this emerging technology.

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Modeling 3D melt electrospinning writing by response surface methodology

Cited by 59 publications

References 48 publications

Biomimicry in Bio-Manufacturing: Developments in Melt Electrospinning Writing Technology Towards Hybrid Biomanufacturing

Biomimicry in Bio-Manufacturing: Developments in Melt Electrospinning Writing Technology Towards Hybrid Biomanufacturing

Empirical modelling and optimization of pressure-coupled infusion gyration parameters for the nanofibre fabrication

The Next Frontier in Melt Electrospinning: Taming the Jet

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