A mathematical model has been developed for heat exchange in nucleate boiling at high flux applying an energy balance on a macrolayer. The wall superheat, macrolayer thickness, and time are the parameters considered for predicting the heat flux. The influence of the wall superheat and macrolayer thickness on average heat flux has been predicted. The outcomes of the current model have been compared with Bhat’s constant macrolayer model, and it was found that these models are in close agreement corresponding to the nucleate pool boiling regime. It was concluded that the wall superheat and macrolayer thickness contributed significantly to conduction heat transfer. The average conduction heat fluxes predicted by the current model and by Bhat’s model are in close agreement for a thinner macrolayer of approximately 50 µm. For higher values of the wall superheat, which corresponds to the nucleate pool boiling condition, the predicted results strongly agree with the results of Bhat’s model. The findings also validate the claim that conduction across the macrolayer accounts for the main heat transfer mode from the heater surface to boiling liquid at high heat flux in nucleate pool boiling.