Large-eddy simulations (LES) of the turbulent flow in a swirl tube with a tangential inlet have been performed. The geometry, and flow conditions were chosen according to an experimental study by [Escudier MP, Bornstein J, Zehnder N. Observations and LDA measurements of confined turbulent vortex flow. J Fluid Mech 1980;98:49-63]. Lattice-Boltzmann discretization was used to numerically solve the Navier-Stokes equations in the incompressible limit. Effects of spatial resolution and choices in subgridscale modeling were explicitly investigated with the experimental data set as the testing ground. Experimentally observed flow features, such as vortex breakdown and laminarization of the vortex core were well represented by the LES. The simulations confirmed the experimental observations that the average velocity profiles in the entire vortex tube are extremely sensitivity to the exit pipe diameter. For the narrowest exit pipe considered in the simulations, very high average velocity gradients are encountered. In this situation, the LES shows the most pronounced effects of spatial resolution and subgrid-scale modeling.