A considerable part of the fuel energy in vehicles never reaches the wheels and entirely converts to waste heat. In a heavy duty vehicle (HDV) the heat power that escapes from the exhaust system may reach 170 kW. The waste heat can be converted into useful electrical power using thermoelectric generator (TEG). During the last decades, many studies on the electrical power conditioning system of TEGs have been conducted. However, there is a lack of studies evaluating the electrical instrumentation, the impact of the converter-efficiency, and the TEG arrangement on a real large-scale TEG on-board a drivable vehicle. In this study, the most important parameters for designing electrical power conditioning systems for two TEGs, developed for a real-scale HDV as well as experimental results demonstrating the recovered electrical power, are presented. Eight synchronous inter-leaved step-down converters with 98 % efficiency with perturb and observe maximum power point tracker was developed and tested for this purpose. The power conditioning system was communicating with the on-board computers through the controller area network and reported the status of the TEGs and the recovered electrical power. The maximum recovered electrical power from the TEGs reached 1 kW which was transmitted to the electrical system of the vehicle, relieving the internal combustion engine.