Modeling and biological evaluation of 3,3′-(1,2-ethanediyl)bis[2-(4-methoxyphenyl)-thiazolidin-4-one], a new synthetic cyclooxygenase-2 inhibitor

Synthesis and antibacterial activity of some novel 2-Aroylimino-3-aryl-thiazolidin-4-ones

“…3 Thiazolidin-4-one derivatives are known to exhibit diverse bioactivities such as anticonvulsant, 4 antidiarrheal, 5 anti-platelet activating factor, 6 antihistaminic, 7 antimicrobial, 8 antidiabetic, 9 cycloxygenase inhibitory, 10 Ca 2+ channel blocker, 11 PAF antagonist, 12 cardioprotective, 13 anti ischemic, 14 anti cancer, 15 anti HIV, 16 non-peptide thrombin receptor antagonist 17 and tumor necrosis factor-α antagonist activities. 18 However, the 2-imino derivatives of thiazolidinones are explored to a lesser extent, in spite of the fact that the presence of imino function provides an additional point of structural diversity in a thiazolidinonebased pharmacophore (Figure 1).…”

Synthesis and Characterization of Schiff Bases and Thiazolidinone Derivatives and Their Microbial Evaluation.

“…Res. 5(6), 2136-2143 2137 cardiovascular [14], anti-inflammatory [15], antidiabetic [16], antihyperlipidemic [17], antimicrobial [18], antituberculosis [19], antiparasitis [20], FSH agonist [21], antiarthritic [22 ] and antidiarrhoeal [23] activity.…”

Synthesis, Nematicidal and Antimicrobial Activity of 3-(5-3-Methyl-5-[(3-methyl-7-5-[2-(aryl)-4-oxo-1,3-thiazolan-3-yl]-1,3,4-thiadiazol-2-ylbenzo[<i>b</i>]furan-5-yl)methyl]benzo[<i>b</i>]furan-7-yl-1,3,4-thiadiazol-2-yl)-2-(aryl)-1,3-thiazolan-4-one

“…Thiazolidine-4-one derivatives are known to exhibit diverse bioactivities such as anti-convulsant, 17) antidiarrheal, 18) antiplatelet activating factor, [19][20][21] anti-histaminic, 22,23) antimicrobial, 24,25) anti-diabetic, 26) cyclooxygenase (COX) inhibitory, 27) Ca 2ϩ -channel blocker, 28) platelet activating factor (PAF) antagonist, 29) cardioprotective, 30) anti-ischemic, 31) anticancer, 32) tumour necrosis factor-a antagonist 33) and nematicidal activities. 34) Nematodes are tiny worms, some of them are plant parasites and can play an important role in the predisposition of the host plant to the invasion by secondary pathogens.…”