Modeling and control in bioprocesses

Guardia, María Jesús

doi:10.1016/s0167-7799(01)01812-1

Cited by 1 publication

(1 citation statement)

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“…Shake flasks, characterized as an integral element of any bioprocess, are not excluded from this fact. To this end, significant attention needs to be paid to provide scientists with detailed and precise models to gain sufficient understanding about behavior of the dynamic systems [11]. In addition, mathematical models are important for computational simulations, provided that the accuracy and limitations of the model are considered [12], [13].…”

Section: Introductionmentioning

confidence: 99%

Novel dynamic model for aerated shaking bioreactors

Tabrizi

Amoabediny

Moshiri

et al. 2011

Biotech and App Biochem

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Abstract.A novel mathematical model of aerated shaking bioreactors is developed and its accuracy is evaluated with experimental data. Corynebacterium glutamicum (DM 1730) and Arxula adeninivorans (WT LS3) are used as model microorganisms. In order to get the experimental data, shake flasks of 250 mL and filling volume of 15 mL, together with online measurement tools for measuring oxygen transfer rate and tools for measuring dry biomass concentration, are used. This mathematical model may be regarded as a key tool for computational simulations or developing model-based control approaches for necessary automation and optimization purposes. Moreover, the error evaluation presented in this paper should be taken into account when using the model. The squared Pearson product-moment correlation coefficient (r 2 ) and average deviation of error are used as two statistical criteria to quantify the accuracy and consistency of the model.

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Section: Introductionmentioning

confidence: 99%