Increasing productivity and efficiency in factories with make-to-order (MTO) production systems have attracted growing interest of academia and industry. In MTO companies, efficient order release and schedule are essential for succeeding in today’s marketplace. However, dynamic demand of customers and constrained resources make it difficult to achieve, as well as limiting the profits. Thus, to overcome the problem of order releasing and multi-item scheduling considering the capacity constrained resources investigated, a heuristic approach is proposed based on the drum-buffer-rope (DBR) method. The proposed heuristic is tested on different types of problems based on due date tightness and demand of products. The performance of the proposed heuristic is compared with other famous heuristic methods in literature. End results indicate that the proposed heuristic based on the DBR method outperforms against the other competitors, and it gives more significant results when optimal buffer size is adopted.