Modeling and optimization of ultrasound-assisted high performance adsorption of Basic Fuchsin by starch-capped zinc selenide nanoparticles/AC as a novel composite using response surface methodology

Sharifpour, Ebrahim; Ghaedi, Mehrorang; Asfaram, Arash; Farsadrooh, Majid; Dil, Ebrahim Alipanahpour; Javadian, Hamedreza

doi:10.1016/j.ijbiomac.2020.02.236

Cited by 54 publications

(14 citation statements)

References 49 publications

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“…This result indicated that adsorption took place at specific homogeneous sites within the PDMS, forming a CF monolayer coverage on the PDMS surface. In addition, the Langmuir isotherm model has been found to be in accordance with already published studies concerning the adsorption of CF dye (Guan et al, 2018;Haddad, 2015;Hinojosa-Reyes et al, 2019;Sharifpour et al, 2020).…”

Section: Adsorption Isothermssupporting

confidence: 88%

Removal of carbol fuchsin from aqueous solution by using three‐dimensional porous, economic, and eco‐friendly polymer

Tarhan

2021

Water Environment Research

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Water resources are the main source of life for living beings on Earth. The world population is growing rapidly, and the need for clean water resources is increasing. Conventional water resources such as rivers, lakes, groundwater, etc., are being exploited to meet freshwater demand. In recent years, environmental pollutants have become one of the most important problems due to their toxic effects on human life and the

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Section: Adsorption Isothermssupporting

confidence: 88%

Removal of carbol fuchsin from aqueous solution by using three‐dimensional porous, economic, and eco‐friendly polymer

Tarhan

2021

Water Environment Research

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“…The central composite design (CCD) was employed to fit a polynomial model and obtain the optimal prescription. 45 Based on single factor experiments, four-parameter (HSA concentration (X1), pH value (X2), volume of ethanol (X3), and the speed of ethanol addition (X4)) were applied to optimize the diameter (Y1), PDI (Y2), and Zeta (Y3) using Design Expert 11 (trial version). 30 groups of experiments were designed.…”

Section: Methodsmentioning

confidence: 99%

Cetuximab-Modified Human Serum Albumin Nanoparticles Co-Loaded with Doxorubicin and MDR1 siRNA for the Treatment of Drug-Resistant Breast Tumors

Yang¹,

Wang²,

Chen³

et al. 2021

IJN

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Background: Breast cancer is the most prevalent cancer among women. Doxorubicin (DOX) is a common chemotherapeutic drug used to treat many different cancers. However, multidrug resistance limits the treatment of breast cancer. MDR1 siRNA (siMDR1) combinatorial therapy has attracted significant attention as a breakthrough therapy for multidrug resistance in tumors. However, naked siRNA is easily degraded by enzymatic hydrolysis requiring an siRNA carrier for its protection. Human serum albumin (HSA) was selected as the carrier due to its excellent biocompatibility, non-toxicity, and non-immunogenicity. Cetuximab was used to modify the HSA nanoparticles in order to target the tumor tissues. Methods:This study used a central composite design response surface methodology (CCD-RSM) to investigate the optimal formula for HSA NPs preparation. Cex-HSA/DOX/MDR1 siRNA (C-H/D/M) was characterized by dynamic light scattering and transmission electron microscopy. The efficacy of C-H/D/M tumor growth inhibitory activity was investigated in vitro and in vivo using confocal imaging, MTT assay, and an MCF-7/ADR tumor-bearing mice model. RT-qPCR, ELISA analysis, and flow cytometry were used to investigate the in vitro antitumor mechanisms of C-H/D/M. Results: The diameter and PDI of the C-H/D/M were 173.57 ± 1.30 nm and 0.027 ± 0.004, respectively. C-H/D/M promoted and maintained the sustained release and the uptake of DOX significantly. After transfection, the MDR1 mRNA and P-gp expression levels were down-regulated by 44.31 ± 3.6% (P < 0.01) and 38.08 ± 2.4% (P < 0.01) in an MCF-7/ADR cell line. The fluorescent images of the treated BALB/c nude mice revealed that C-H/D/M achieved targeted delivery of siMDR1 and DOX into the tumor tissue. The in vivo tumor inhibition results demonstrated that the tumor inhibition rate of the C-H/D/M treated group was 54.05% ± 1.25%. The biosafety results indicated that C-H/D/M did not induce significant damages to the main organs in vivo. Conclusion: C-H/D/M can be used as an ideal non-viral tumor-targeting vector to overcome MDR and enhance the antitumor effect.

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“…15,16 Furthermore, polyaniline, a common conductive polymer, has attracted the attention of researchers in recent years due to its low cost, ease of synthesis, environmental stability. 17,18 Then, most studies about adsorption focused on the use of polyaniline and its composites because of its large amount of aniline and imine nitrogen. 19 A traditional study can be conducted to determine the good conditions of the treatment effect, but it requires more time and reactive products, which raises the cost invested in the study and design of the treatment.…”

Section: Introductionmentioning

confidence: 99%

“…Hence, predictive analytics studies are used by scientists for resolving environmental problems. 18,20,21 Thus, response surface methodology (RSM) can be used to study the effect of different variables influencing the removal of Cr(VI) from water in order to determine the best possible operating conditions.…”

Section: Introductionmentioning

confidence: 99%

Use of experimental design to evaluate the adsorption of chromium (VI) by alginate/polyaniline beads

Abdelmajid¹,

Benkhaled

Attar

et al. 2022

JSCS

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Within, low-cost decorated sodium alginate beads with polyaniline (Alg@PANI beads) were easily prepared using a cross-linking method, and employed for the adsorption of Cr(VI) from aqueous solutions. The effect of several influencing parameters, including temperature, contact time, Cr(VI) con-centration, and adsorbent dosage, was investigated and optimized using central composite design (CCD) under response surface methodology (RSM). The analysis of variance (ANOVA) of the quadratic model and the analyzed model revealed that models were statistically significant, with a low P-value (<0.0001) and a higher correlation coefficient value (R2 = 0.93). The optimum parameters for total adsorption were as follows: adsorbent dose = 0.027 g, pH 2, contact time = 45 min, temperature = 38 ?C, and Cr(VI) concentration = 29.24 ppm. The findings of this study indicate that the prepared Alg@PANI beads could be used effectively to remove Cr(VI) ions from aqueous solutions.

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Modeling and optimization of ultrasound-assisted high performance adsorption of Basic Fuchsin by starch-capped zinc selenide nanoparticles/AC as a novel composite using response surface methodology

Cited by 54 publications

References 49 publications

Removal of carbol fuchsin from aqueous solution by using three‐dimensional porous, economic, and eco‐friendly polymer

Removal of carbol fuchsin from aqueous solution by using three‐dimensional porous, economic, and eco‐friendly polymer

Cetuximab-Modified Human Serum Albumin Nanoparticles Co-Loaded with Doxorubicin and MDR1 siRNA for the Treatment of Drug-Resistant Breast Tumors

Use of experimental design to evaluate the adsorption of chromium (VI) by alginate/polyaniline beads

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